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Photosensitive resin/beta-tricalcium phosphate composite biological ink capable of being used for DLP printing and preparation method of photosensitive resin/beta-tricalcium phosphate composite biological ink

A technology of photosensitive resin and tricalcium phosphate, which is applied in the direction of additive manufacturing, manufacturing tools, tissue regeneration, etc., can solve the problems of slow degradation rate of bone repair materials at sintering temperature, difficulty in controlling the shape and size of pores, and poor pore connectivity. High material utilization rate, fast molding speed, and good biocompatibility

Inactive Publication Date: 2021-01-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 3D printing technology has been widely used in the research of biomaterials in recent years, especially in the manufacture of porous scaffolds. It has advantages in the design and manufacture of pore shape, structure and size, and can solve the problem of poor pore connectivity in the preparation of β-tricalcium phosphate porous bioceramics by traditional methods. , It is difficult to control the shape and size of the hole, etc.
Also, the Chinese patent publication CN110092653A provides a preparation method for extruding 3D printing degradable β-tricalcium phosphate porous bioceramic scaffolds. By adding bioactive glass, the sintering temperature of β-tricalcium phosphate porous bioceramic scaffolds is reduced to solve the problem of osteoarthritis. The problem of slow degradation rate and low biological activity of repair materials

Method used

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  • Photosensitive resin/beta-tricalcium phosphate composite biological ink capable of being used for DLP printing and preparation method of photosensitive resin/beta-tricalcium phosphate composite biological ink
  • Photosensitive resin/beta-tricalcium phosphate composite biological ink capable of being used for DLP printing and preparation method of photosensitive resin/beta-tricalcium phosphate composite biological ink
  • Photosensitive resin/beta-tricalcium phosphate composite biological ink capable of being used for DLP printing and preparation method of photosensitive resin/beta-tricalcium phosphate composite biological ink

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Add β-tricalcium phosphate powder to 90% ethanol solution of KH550 for modification (mass volume ratio is 10%), and the addition ratio of silane coupling agent is 1wt% of β-tricalcium phosphate ceramic powder , Reaction at 75°C for 6 hours, ball milling after drying.

[0035] (2) Weigh 25g of polyethylene glycol diacrylate, 5g of PEGDMA, and 0.15g of BAPO, mix them by magnetic stirring for 30 minutes, and let stand for 1 day to obtain a photosensitive resin system.

[0036] (3) 20.2 g of modified β-tricalcium phosphate ceramic powder was added in batches to the photosensitive resin system, and ultrasonically dispersed to obtain a ceramic slurry.

[0037] (4) Add the ceramic slurry into the trough of the light-curing printer, adjust the exposure time to 1.3s, open the sliced ​​bracket model file, and print the bracket blank.

[0038] (5) The green body is dried, degreased, and sintered at high temperature to obtain the bracket. The sintering route is: 0.5°C / min fro...

Embodiment 2

[0040] (1) Add β-tricalcium phosphate powder to 90% ethanol solution of KH550 for modification (mass volume ratio is 10%), and the addition ratio of silane coupling agent is 2wt% of β-tricalcium phosphate ceramic powder , Reaction at 85°C for 5 hours, ball milling after drying.

[0041] (2) Weigh 23g of polyethylene glycol diacrylate, 2g of HDDA, 5g of PEGDMA, and 0.45g of BAPO, mix them by magnetic stirring for 30 minutes, and let stand for 1 day to obtain a photosensitive resin system.

[0042] (3) 30.4 g of modified tricalcium phosphate ceramic powder was added in batches to the photosensitive resin system, and ultrasonically dispersed to obtain a ceramic slurry.

[0043] (4) Add the ceramic slurry into the trough of the light-curing printer, adjust the exposure time to 1.4s, open the sliced ​​bracket model file, and print the bracket blank.

[0044] (5) The green body is dried, degreased, and sintered at high temperature to obtain the bracket. The sintering route is: 0.8...

Embodiment 3

[0046] (1) Add β-tricalcium phosphate powder to 90% ethanol solution of KH570 for modification (mass volume ratio is 10%), and the addition ratio of silane coupling agent is 4wt% of β-tricalcium phosphate ceramic powder , Reaction at 75°C for 6 hours, ball milling after drying.

[0047] (2) Weigh 22.4g of polyethylene glycol diacrylate, 2.6g of HDDA, 5g of CEA, and 0.45g of BAPO, mix them by magnetic stirring for 30 minutes, and let them stand for 1 day to obtain a photosensitive resin system.

[0048] (3) 45.4 g of modified tricalcium phosphate ceramic powder was added in batches to the photosensitive resin system, and ultrasonically dispersed to obtain a ceramic slurry.

[0049](4) Add the ceramic slurry into the trough of the light-curing printer, adjust the exposure time for 1.5s, open the sliced ​​bracket model file, and print the bracket blank.

[0050] (5) The green body is dried, degreased, and sintered at high temperature to obtain the bracket. The sintering route i...

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Abstract

The invention belongs to the field of biological materials, and discloses photosensitive resin / beta tricalcium phosphate composite biological ink capable of being used for DLP printing and a preparation method of the photosensitive resin / beta tricalcium phosphate composite biological ink. The preparation method comprises the following steps: carrying out surface treatment on beta tricalcium phosphate powder by using a silane coupling agent, mixing the beta tricalcium phosphate powder with photosensitive resin to prepare composite ink, carrying out photocuring 3D printing, and sintering to obtain the porous scaffold for bone tissue repair. The preparation method of the porous scaffold has the advantages of simplicity, short forming time and the like, and the scaffold with high pore connectivity and controllable shape and size can be conveniently obtained through structural design, so that the scaffold can be widely applied to the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a photosensitive resin / β-tricalcium phosphate composite biological ink which can be used for DLP printing and a preparation method thereof. Background technique [0002] β-tricalcium phosphate [β-Ca 3 (PO 4 ) 2 ](β-TCP) composition is similar to the inorganic components of human bone tissue, its solubility in body fluids is higher than that of hydroxyapatite, and it can be slowly degraded. It has been widely used in the field of bone repair (see: Eliaz, N., & Metoki, N. Materials, 2017, 10(4), 334.). After β-TCP is implanted into the defect site, a balance of calcium and phosphorus is formed on the upper interface and deposited on the interface, which has a good bone conduction effect; the degradation of β-TCP provides more abundant calcium and phosphorus ions, and promotes the formation of new bone tissue (see : Ma, H., Feng, C., Chang, J., & Wu, C. Acta bioma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/56A61L27/46B29C64/135B33Y80/00B33Y10/00B33Y70/10
CPCA61L27/46A61L27/56A61L27/58A61L2430/02A61L2430/12B33Y10/00B33Y70/00B33Y80/00B29C64/135
Inventor 刘卅任力莫丽娜贾永光杨军忠严迪威陈盛贵
Owner SOUTH CHINA UNIV OF TECH
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