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Absorbable and degradable suture line

A suture and polylactic acid technology, applied in the field of degradable sutures and absorbability, can solve the problems of unstable degradation speed of polylactic acid sutures, reduced strength and toughness of polylactic acid sutures, poor hydrophilicity of polylactic acid sutures, etc. , to achieve the effect of eliminating adverse effects, improving force, and high flexibility

Inactive Publication Date: 2021-02-05
浙江桐轩医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Polylactic acid is a new type of green and environmentally friendly biodegradable material. It is a polymer polyester material synthesized from starchy substances extracted from renewable plants (such as cassava and corn). The source of raw materials is rich and renewable. The suture made The thread has a silky feel, and the degradation products can be quickly absorbed by human tissues, but the polylactic acid suture has poor hydrophilicity and weak cell adhesion
In addition, the poor crystallization ability of PLA reduces the strength and toughness of PLA sutures
The degradation rate of polylactic acid sutures in the body is also unstable

Method used

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  • Absorbable and degradable suture line
  • Absorbable and degradable suture line

Examples

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preparation example Construction

[0037] A second aspect of the present invention provides a method for preparing absorbable and degradable sutures, comprising the following steps:

[0038]S1. Preparation of suture fiber: put degradable base material, polyglycolic acid, polylactide, chitosan, polyethylene glycol, lubricant, antibacterial agent into the reaction kettle and mix evenly, heat to 100-120°C , stirred at a speed of 500-800r / min for 3-4 hours to obtain a mixture; then put the mixture into a twin-screw extruder for extrusion, the extrusion temperature is 200-240°C, the screw speed is 900-1200r / min, after Water-cooled, air-dried, and pelletized to obtain masterbatches; heat the obtained masterbatches to 140-180°C to melt, defoam, and obtain primary fibers through a spinneret; stretch the primary fibers in a water bath of 50-80°C to obtain suture fibers;

[0039] S2. Drying and sterilization: the suture fiber is further dried and sterilized with ethylene oxide to obtain absorbable and degradable suture....

Embodiment 1

[0045] Embodiment 1 provides an absorbable and degradable suture. In parts by weight, the preparation raw materials include the following components: 70 parts of modified polylactic acid, 10 parts of polyglycolic acid, 10 parts of polyethylene lactide, chitosan 15 parts of sugar, 3 parts of polyethylene glycol, 3 parts of cinnamon oil, 2 parts of cinnamaldehyde;

[0046] The preparation method of described modified polylactic acid is as follows:

[0047] In parts by weight, add 14 parts of L-polylactic acid (the intrinsic viscosity is 1.50-2.00dL / g, purchased from Wuhan Haishan Technology Co., Ltd., model is PLLA-20), 1 part of polycaprolactone (viscosity The average molecular weight is 50000, purchased from Shenzhen Guanghua Weiye Co., Ltd., the model is Esun500C), 500 parts of dichloromethane solvent, stirred for 3.5h, so that L-polylactic acid and polycaprolactone are fully dissolved in dichloromethane solvent to obtain a solution, Transfer the solution to a petri dish, pu...

Embodiment 2

[0056] Similar to Example 1, an absorbable and degradable suture and its preparation method are provided, but the preparation raw materials include by weight parts: 60 parts of modified polylactic acid, 10 parts of polyglycolic acid, 10 parts of polyglycolide 15 parts of chitosan, 3 parts of polyethylene glycol, 3 parts of cinnamon oil, and 2 parts of cinnamaldehyde.

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Abstract

The invention discloses an absorbable and degradable suture line. The absorbable and degradable suture line is prepared from the following raw materials in parts by weight: 60 to 80 parts of a degradable base material, 5 to 15 parts of polyglycolic acid, 5 to 15 parts of polyglycolide, 10 to 20 parts of chitosan, 1 to 5 parts of polyethylene glycol, 2 to 3 parts of a lubricating agent and 1 to 3 parts of an antibacterial agent. The absorbable and degradable suture line has excellent tensile strength and toughness, also has good absorbability and degradability, and also has excellent antibacterial and bacteriostatic properties and hydrophilicity.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an absorbable and degradable suture. Background technique [0002] Surgical suture refers to the special thread used for ligation hemostasis, suture hemostasis and tissue suture in surgical operation or trauma treatment. It can generally be divided into two categories: absorbable thread and non-absorbable thread. According to different materials and absorption degree, it is divided into: catgut, chemical synthetic thread, and pure natural collagen suture. [0003] Polylactic acid is a new type of green and environmentally friendly biodegradable material. It is a polymer polyester material synthesized from starchy substances extracted from renewable plants (such as cassava and corn). The source of raw materials is rich and renewable. The suture made The thread has a silk-like feel, and the degradation products can be quickly absorbed by human tissues, but the polylactic a...

Claims

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Application Information

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IPC IPC(8): A61L17/12A61L17/10
CPCA61L17/10A61L17/105A61L17/12
Inventor 沈坤
Owner 浙江桐轩医疗科技有限公司