Porous hollow Co3O4 nano prism and enzyme-free glucose sensor based on porous hollow Co3O4 nano prism

Abstract

The invention relates to a porous Co3O4 nano prism, a preparation method of the porous Co3O4 nano prism, an enzyme-free glucose sensor based on the nano prism and a preparation method and applicationof the enzyme-free glucose sensor. The preparation method of the nano prism comprises the following steps: reacting cobalt acetate and an ethanol solution of a nitrogen-containing organic matter at aconstant temperature of 60-70 DEG C for 1-6h, separating to obtain a precursor, and drying the precursor; and firing at a constant temperature of 300-500 DEG C in an air atmosphere to obtain the product. The nano prism is directly used as an electrode material of an enzyme-free glucose sensor, other conductive carriers are not needed, and the nano prism shows excellent electrocatalytic oxidation performance and has high sensitivity, low detection limit, wide linear response range, good selectivity and high stability. By using the enzyme-free glucose sensor, serum can be directly used for bloodglucose detection without dilution treatment. The method has the advantages of simple preparation, convenience, rapidness, synthesis by adopting cheap and easily available raw materials, low cost, good sample reproducibility, suitableness for large-scale production, and development potential and application prospect.

Description

technical field [0001] The invention belongs to the field of electrochemical biosensing, in particular to a porous hollow Co 3 o 4 Nano prism, its preparation method, and an enzyme-free glucose sensor based on the nano prism, its preparation method and application. Background technique [0002] Glucose detection has important applications in clinical diagnosis, food industry and biotechnology. So far, most electrochemical biosensors use enzyme-based electrodes such as glucose oxidase, horseradish peroxidase or heme as The catalyst performs oxidation or reduction. Among them, glucose oxidase-based biosensors are widely used due to their high sensitivity. Although glucose oxidase is more stable than other enzymes, due to the inherent instability of enzyme molecules, biocomponent-based biosensors are still affected by various environmental factors such as temperature, pH, oxygen, humidity, organic reagents and Toxic substances, etc., thereby affecting the sensitivity, stabi...

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Problems solved by technology

Noble metals and their alloy catalysts usually have the disadvantages of low sensitivity and poor stability due to surface poisoning due to the adsorption of intermediates and chlorides; NiO, CuO and Co 3 o 4 Due to the advantages of lower cost and better biocompatibility than noble metals, transition metal oxides such as Co 3 o 4 It is a magnetic semiconductor material, and it has attracted more research interest due to its simple synthesis method, high electrocatalytic activity and low cost.

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