Nanoparticle composite showing improved endocytosis efficiency through surface modification using lipid and manufacturing method therefor

A nanoparticle and manufacturing method technology, applied in the direction of liposome delivery, other methods of inserting foreign genetic materials, medical preparations of non-active ingredients, etc., can solve the problems of decreased stability and insufficient achievement, and achieve large-scale The effect of mass production
CN112423738AActive Publication Date: 2021-02-26IND UNIV COOP FOUND SOGANG UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
IND UNIV COOP FOUND SOGANG UNIV
Publication Date
2021-02-26

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Abstract

The present invention relates to a nanoparticle composite, which is endocytosed into cells and used to treat a disease, and to a manufacturing method therefor. More specifically, the present inventionrelates to a nanoparticle composite and a manufacturing method therefor, wherein the nanoparticle composite shows improved endocytosis efficiency by modifying the nanoparticle surface with a lipid-based material having high stability and excellent biocompatibility; the nanoparticle composite can attain direct passage through the cellular membrane as well as endocytosis, and can be effectively endocytosed into spheroid-shaped tumor cells, by having a tube-shaped lipid structure combined with a portion of the nanoparticle surface; and the nanoparticle composite can be easily mass-produced by using a top-down manner, in which, the lipid structure is not attached directly to the nanoparticle, but the binding of the nanoparticle and the lipid-based lipidome (bubble, liposome, etc.) is induced,and then the physical force is applied thereto to disrupt the lipidome, thereby forming the lipid structure on the nanoparticle surface.
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Description

technical field

[0001] The present invention relates to a nanoparticle complex used for treatment of diseases by being taken up into cells and a method for producing the same, and particularly relates to a lipid-based substance that can be used to treat diseases with high stability and excellent biocompatibility Modifying the surface of nanoparticles to improve the efficiency of intracellular uptake can achieve endocytosis and even directly penetrate the cell membrane by combining a tubular lipid structure on the surface of nanoparticles, and can also be effectively absorbed by tumor cells in the form of spheroids. uptake, and can be broken up by applying mechanical force after binding lipid-based liposomes (such as microvesicles, membrane vesicles, etc.) to nanoparticles and thereby forming lipid structures on the surface of nanoparticles A nanoparticle complex and a manufacturing method thereof that can be easily mass-produced in a top-down manner. Background technique ...

Claims

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