Hydrogel eye pad for adjuvant therapy of central serous choroidal retinopathy and preparation method of hydrogel eye pad

A technology for retinopathy and hydrogel eye patches, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, skin diseases, etc., can solve the problems of inability to prevent recurrence, accelerate the absorption of retinal edema, and inconvenient use And other issues

Active Publication Date: 2021-03-02
HENAN ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the treatment methods for CSC mainly include laser photocoagulation, photodynamic therapy (PDT), micropulse laser, transpupil thermotherapy (TTT) and indocyanine green-mediated photoembolization therapy; There are certain limitations and adverse reactions, such as laser photocoagulation can accelerate the absorption of retinal edema, shorten the course of the disease, and reduce the incidence; but it does not target the cause and cannot prevent recurrence
In terms of traditional Chinese medicine treatment, Chinese medicine extraction preparations, compound preparations, empirical prescriptions and other treatment methods are used, and the effect is good. However, Chinese medicine treatment has problems such as long treatment period and inconvenient use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A hydrogel eye patch for auxiliary treatment of central serous chorioretinopathy, which is made of the following raw materials in percentage by weight: 0.01% tea essential oil, 0.2% tea polyphenols, 0.5% theanine, 0.2% tea pigment, 0.01% jasmine essential oil, 0.5% safflower extract, 0.5% salvia miltiorrhiza extract, 0.8% kudzu root extract, 0.8% dandelion extract, 1.0% green scorpion extract, 0.2% atractylodes extract, 0.5% mallow seed extract 0.5% licorice extract, 8% polyacrylamide, 11% sodium polyacrylate, 23% glycerin, 0.2% citric acid, 1% sorbitol, 0.1% aluminum hydroxide, 50.98% purified water.

[0039] The preparation method of the above-mentioned tea essential oil is as follows: the green tea leaves are pulverized (40 mesh) and subjected to CO 2 The tea essential oil is obtained by supercritical extraction, wherein the extraction temperature is 30° C., the pressure is 10 MPa, and the extraction time is 2 hours. The preparation method of above-mentioned jasmin...

Embodiment 2

[0049] A hydrogel eye patch for auxiliary treatment of central serous chorioretinopathy, which is made of the following raw materials in percentage by weight: 0.02% tea essential oil, 0.3% tea polyphenols, 0.4% theanine, 0.1% tea pigment, 0.04% jasmine essential oil, 0.5% safflower extract, 0.5% salvia miltiorrhiza extract, 0.4% kudzu root extract, 0.4% dandelion extract, 0.8% green jasmine extract, 1.0% atractylodes extract, 0.6% mallow seed extract 0.2% licorice extract, 10% polyacrylic acid, 10% sodium polyacrylate, 30% glycerin, 0.4% citric acid, 1.8% sorbitol, 0.2% aluminum hydroxide, 42.34% purified water.

[0050] The preparation method of the above-mentioned tea essential oil is as follows: the green tea leaves are pulverized (40 mesh) and subjected to CO 2 The tea essential oil is obtained by supercritical extraction, wherein the extraction temperature is 30° C., the pressure is 12 MPa, and the extraction time is 5 hours. The preparation method of above-mentioned ja...

Embodiment 3

[0060] A hydrogel eye patch for auxiliary treatment of central serous chorioretinopathy, which is made of the following raw materials in percentage by weight: 0.04% tea essential oil, 0.6% tea polyphenols, 0.2% theanine, 0.2% tea pigment, 0.04% jasmine essential oil, 0.5% safflower extract, 0.5% salvia miltiorrhiza extract, 1.0% kudzu root extract, 1.0% dandelion extract, 1.5% green scorpion extract, 1.2% atractylodes extract, 0.8% mallow seed extract 0.2% licorice extract, polymethacrylic acid 12%, sodium polyacrylate 10%, sodium carboxymethylcellulose 3%, glycerin 25%, citric acid 0.3%, sorbitol 2%, aluminum hydroxide 0.3 %, purified water 36.62%.

[0061] The preparation method of the above-mentioned tea essential oil is as follows: the green tea leaves are pulverized (40 mesh) and subjected to CO 2 The tea essential oil is obtained by supercritical extraction, wherein the extraction temperature is 60° C., the pressure is 20 MPa, and the extraction time is 1.5 h.

[0062...

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PUM

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Abstract

The invention relates to a hydrogel eye pad for adjuvant therapy of central serous choroidal retinopathy. The hydrogel eye pad is mainly prepared from the following raw materials in percentage by weight, 0.01-0.04% of tea essential oil, 0.2-0.8% of tea polyphenol, 0.1-0.6% of theanine, 0.1-0.6%of tea pigment, 0.01-0.04% of jasmine flower essential oil, 0.2-1.0% of safflower extract, 0.2-1.0% of Danshen Extract, 0.2-1.5% of kudzu extract, 0.2-1.5% of dandelion extract, 0.2-1.5% of Celosia argentea extract, 0.2-1.5% of Atractylodes extract, 0.2-1.0% of okra extract, 0.2-1.0% of licorice extract,10-25% of polymer material, 20-30% of glycerol, 0.1-0.5% of citric acid, 1-3% of sorbitol, 0.1-0.3% of aluminum hydroxide, and the balance of purified water. The hydrogel eye pad is an external patch, has the faint scent of jasmine and green tea, can promote absorption of subretinal effusion, shorten the course of disease and improve eyesight, and has the effects of soothing the nerves, resistingwrinkles and the like.

Description

technical field [0001] The invention belongs to the technical field of eye patches, and in particular relates to a hydrogel eye patch for auxiliary treatment of central serous chorioretinopathy and a preparation method thereof. Background technique [0002] Central serous chorioretinopathy (CSC), also known as "CSC", is a common retinal macular lesion, which is caused by damage to the retinal pigment epithelium of the fundus, mainly in the macular area, and spreads to the retinal neuroepithelium of the nearby retina. A lesion characterized by a localized superficial serous detachment. The disease is more common in men aged 20-45, and it is mostly monocular. It is a self-limiting disease. Patients manifested as sudden loss of monocular vision, hazy vision, darkened scenery, smaller vision, and distorted straight lines. Although most patients can recover on their own within 3-6 months, patients who recover on their own are prone to relapse, and after multiple relapses, it ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/70A61K47/10A61K47/12A61K47/02A61K47/32A61K47/38A61P27/02A61P25/00A61P17/00A61K31/353A61K31/198
CPCA61K36/82A61K31/353A61K31/198A61K36/63A61K36/286A61K36/537A61K36/488A61K36/288A61K36/21A61K36/284A61K36/185A61K36/484A61K9/7023A61K9/0014A61K9/0048A61K47/10A61K47/12A61K47/02A61K47/32A61K47/38A61P27/02A61P25/00A61P17/00A61K2236/37A61K2236/331A61K2236/55A61K2236/33A61K2236/35A61K2300/00Y02P20/54
Inventor 陈玲李晓范毅宁二娟王学方魏悦李智宁于立芹
Owner HENAN ACAD OF SCI
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