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Method for reducing anisidine value in polyunsaturated fatty acid oil

A technology for unsaturated fatty acid and anisidine value is applied in the field of efficiently reducing the anisidine value of polyunsaturated fatty acid oil, and can solve the problems of reducing peroxide value, complicated process, reducing DHA oil and the like, so as to reduce adsorption loss and reduce system Viscosity, the effect of reducing peroxide value

Pending Publication Date: 2021-03-02
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] CN108611190A also discloses a fish oil concentrate. The preparation method includes removing the anisidine value with an adsorbent twice successively after urea inclusion, and there is also the problem of excessive loss of active ingredients.
[0013] CN101497026B discloses a decolorizing agent for reducing the anisidine value of soybean oil for injection and a preparation method thereof, involving the preparation of the decolorizing agent, and the process is quite complicated
[0016] CN105733818A describes a method for reducing the anisidine value of DHA oil, which mainly consists of successively adding concentrated phosphoric acid and primary amine compounds for reaction, and then performing high-pressure silica gel column chromatography. The process is complicated and will eventually introduce more impurities into the product
[0017] CN102976936B invented a method for reducing the peroxide value and anisidine value in unsaturated fatty acid ethyl esters, using sodium borohydride to react with carbon-oxygen double bonds, thereby converting aldehydes and ketones into alcohols, thereby reducing the peroxide value and The purpose of the anisidine value, there is a hidden danger in the safety aspect in the reaction process
[0018] In a word, among the above-mentioned methods for reducing the anisidine value, the use of a strong reducing agent by the chemical method will bring safety risks in production and introduce organic impurities into the final product, while the physical method is a simple method. However, in the previous methods, there is a problem that the adsorbent will take away more polyunsaturated fatty acids, resulting in lower product yields. It is necessary to find a method that can easily reduce the anisidine value in the polyunsaturated fatty acid oil, and at the same time A method with little loss of polyunsaturated fatty acids

Method used

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  • Method for reducing anisidine value in polyunsaturated fatty acid oil
  • Method for reducing anisidine value in polyunsaturated fatty acid oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] With 1500g triglyceride type polyunsaturated fatty acid fish oil raw material (Zhejiang Pharmaceutical Co., Ltd. Xinchang pharmaceutical factory production, specification: 5020TG) (EPA 50.2%, DHA 20.8%, total polyunsaturated fatty acid content is 77.4%, peroxide value 12.0 , anisidine value 25.8), add 7500ml of absolute ethanol, stir and dissolve at 30°C. Add 100g of activated clay and 50g of activated carbon, keep stirring and adsorbing at 30°C for 1.0hr, filter the adsorbent activated clay and activated carbon, the filtration is completed within 10min, and then purge the filter cake with high-purity nitrogen for 15min until there is no continuous liquid drops appear. The solvent absolute ethanol in the above filtrate was vacuum recovered to obtain crude fish oil.

[0037] The above crude fish oil was subjected to primary molecular distillation at 200 Pa and 130°C to remove light components to obtain 1408.5 g of fish oil product with a peroxide value of 4.2 and anisid...

Embodiment 5

[0049] The ethyl ester type polyunsaturated fatty acid raw material that 600g fermentation method obtains (Zhejiang Pharmaceutical Co., Ltd. Xinchang pharmaceutical factory produces, specification: 0525EE) (EPA 4.1%, DHA 25.2%, total polyunsaturated fatty acid content is 30.8%, peroxidation value 13.5, anisidine value 37.9), add 60ml of hexane, stir and dissolve at 20°C. Add 3g of activated carbon, keep stirring and adsorbing at 20°C for 1.0hr, filter the adsorbent activated carbon, the filtration is completed within 2min, and then purge the filter cake with high-purity carbon dioxide gas for 5min until no continuous droplets appear. The solvent ethane in the above filtrate was vacuum recovered to obtain crude algae oil.

[0050] Thin film distillation of the crude algae oil above at 30Pa and 80°C removes light components, then raise the temperature to 170°C and vacuum at 5Pa to obtain the positive fraction, which is 552g of ethyl ester type algae oil with a peroxide value of ...

Embodiment 6

[0052] With 1500g triglyceride type conjugated linoleic acid raw material (produced by Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory, specification: 70TG) (content is 70.5%, peroxide value 12.1, anisidine value 38.3), add 3000ml ethyl acetate, Stir to dissolve at 50 °C. Add 50g of activated carbon and 25g of diatomaceous earth, keep stirring and adsorbing at 50°C for 1.0hr, filter the adsorbent activated carbon and diatomite, the filtration is completed within 7min, and then purge the filter cake with high-purity nitrogen for 6min until no Continuous droplets appear. The solvent ethyl acetate in the above filtrate was recovered in vacuo to obtain the crude conjugated linoleic acid.

[0053] The above crude conjugated linoleic acid was subjected to 50Pa, 120°C falling film distillation to remove the light components, and the product conjugated linoleic acid was 1397.2g, the peroxide value was 4.7, and the anisidine value was 12.4. 165.8 g of the filter cak...

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Abstract

The invention provides a method for reducing anisidine value in polyunsaturated fatty acid oil, and the method comprises the following steps of: dissolving a polyunsaturated fatty acid raw material inan organic solvent, adding an adsorbent, performing stirring and adsorbing at a low temperature, performing filtering to remove the adsorbent, blow-drying the liquid component in the adsorbent with inert gas, and recovering the organic solvent in the filtrate to obtain a crude product, and carrying out molecular distillation or rectification on the crude product to obtain the polyunsaturated fatty acid oil with low anisidine value. According to the method, the use amount of the adsorbent is small in the technological process, the anisidine value reducing effect is obvious, the loss of polyunsaturated fatty acid is small, the final product polyunsaturated fatty acid oil obtained through the method is free of peculiar smell, and the requirements of consumers can be well met; the adsorbent applied or added in the production process can effectively reduce the peroxide value and anisidine value of the final product, and also has a certain removal effect on other trace substances such as color, heavy metals, dioxin, benzopyrene and the like in the product.

Description

technical field [0001] The invention mainly describes a method for efficiently reducing the anisidine value of polyunsaturated fatty acid oil through an adsorption method. It belongs to the field of biochemical industry. Background technique [0002] As people pay more and more attention to their own health, the public begins to take more nutritional and healthy dietary supplements, in which polyunsaturated fatty acid (PUFA) products play an important role. [0003] Polyunsaturated fatty acid (PUFA) is an important material basis for body metabolism, especially for infant brain development and other activities. It is a component of cell membranes and mainly plays a role in maintaining the fluidity of cell membranes, promoting cholesterol esterification, and reducing cholesterol and triglycerides. , reduce blood viscosity, improve blood circulation and other physiological functions, and also have the functions of improving human thinking and enhancing memory. The human body...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B3/00C11B3/10C11B3/12
CPCC11B3/001C11B3/006C11B3/10C11B3/008C11B3/12
Inventor 许新德谢恬彭永健王升帆
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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