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Pharmaceutical composition containing chemical ablating agent and pH regulator as well as application of pharmaceutical composition

A technology of composition and regulator, which is applied in the directions of drug combination, medical preparations containing active ingredients, drug delivery, etc., to achieve the effects of non-toxic systemic safety, low local irritation, and effective treatment

Inactive Publication Date: 2021-03-05
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, there is still a need to develop new drugs for the treatment of local disease such as solid tumors, especially local drugs, to meet various clinical needs that cannot be met by existing technologies

Method used

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  • Pharmaceutical composition containing chemical ablating agent and pH regulator as well as application of pharmaceutical composition
  • Pharmaceutical composition containing chemical ablating agent and pH regulator as well as application of pharmaceutical composition
  • Pharmaceutical composition containing chemical ablating agent and pH regulator as well as application of pharmaceutical composition

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Experimental program
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preparation example Construction

[0160]According to the preparation method of the present invention, the preparation of the pharmaceutical composition of the present invention comprises the following steps: preparing a liquid medicine containing the necessary components (such as the pharmaceutical composition) and other substances optionally present. The liquid drug may be a solution (eg, a solution in a hydrophilic vehicle, preferably an aqueous solution), a suspension, or an emulsion. When the liquid drug is a suspension, the dispersion medium therein can be any suitable one known to those skilled in the art, such as micro-materials or nano-materials. When the liquid drug is an emulsion, the dispersion medium therein can be any suitable one known to those skilled in the art, such as vegetable oil, synthetic oil or semi-synthetic oil that can be used for injection. Wherein said vegetable oil may be, for example, cottonseed oil, almond oil, olive oil, castor oil, sesame oil, soybean oil and peanut oil.

[01...

Embodiment 1

[0207] Embodiment 1: the preparation of pharmaceutical composition

[0208] According to the preparation method of the pharmaceutical composition of the present invention described above, many different topical pharmaceutical compositions of the present invention can be formulated. Several examples of preparation tests of the pharmaceutical composition of the present invention are listed below.

[0209] 1. Preparation of liquid injection

[0210] Measure the necessary components in the pharmaceutical composition according to the required concentration (such as chemical ablative agent 3g sodium hydroxide, pH regulator 7g sodium bicarbonate), optional other components and set the volume to the total volume (such as 100ml) The liquid carrier (such as water for injection), and they are slowly mixed evenly, and after sterilizing and filtering, they are divided into required quantities (such as 10ml / bottle) and stored for later use. This preparation (eg, 7% sodium bicarbonate / 3% a...

Embodiment 2

[0218] Embodiment 2: the synergy research of composition

[0219] In one experiment, successfully modeled experimental animals (bearing S180 mice, with an average tumor volume of 314mm 3 ) were randomly divided into 2 negative control groups (01, 02) and 9 drug study groups (1-9). The negative control was physiological saline, and the research drugs were listed in the table below. The medicines are all aqueous solutions, which are prepared according to the preparation method of Example 1. The negative control substance and the research drug were injected intraperitoneally (groups 02, 6, and 9) and injected intratumorally (other research groups). Each group was treated once every 3 days, a total of 3 times, and the injection volume was 150ul / mouse. Five days after the end of the medication, the animals were euthanized, the tumor weight was measured after dissection, and the tumor inhibition rate was calculated from the negative control group. The results are shown in Table 4...

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Abstract

The invention relates to a pharmaceutical composition containing a chemical ablating agent and a pH regulator as well as application of the pharmaceutical composition as a local active ingredient in preparation of a local medicament for treating local lesion diseases.

Description

technical field [0001] The present disclosure relates to a pharmaceutical composition comprising a chemical ablative agent and a pH adjusting agent, and its use as a topical active ingredient in the preparation of a topical medicament for the treatment of locally diseased diseases. Background technique [0002] Solid tumors are often used as a model for studies of localized disease, especially refractory localized disease, as supported by extensive research work. A solid tumor is a tumor disease with tumor symptoms, which is a characteristic diseased tissue containing tumor cells. Taking pancreatic cancer tumors as an example, pancreatic cancer cells only account for about 30% of the tumor volume. It can be seen that in addition to tumor cells, there are often a large number of other components (sometimes also called the microenvironment of tumor cells) in tumor tissues, including other types of cells, various interstitial cells, and various pipelines. [0003] Topical adm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/00A61K47/02A61K47/04A61K47/18A61K47/12A61K47/22A61K45/06A61P35/00A61P29/00A61P17/00
CPCA61K9/0014A61K45/00A61K45/06A61K47/02A61K47/12A61K47/18A61K47/22A61P17/00A61P29/00A61P35/00
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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