Apostichopus japonicus and sea cucumber flower lipid extract as well as preparation method and application thereof

Abstract

The invention provides an apostichopus japonicus and sea cucumber flower lipid extract as well as a preparation method and application thereof. The sea cucumber flower lipid extract mainly contains 20fatty acids such as eicosapentaenoic acid and docosahexaenoic acid and the like, wherein 13 unsaturated fatty acids are contained, and the relative percentage content is not less than 70%. The extracted and purified sea cucumber flower lipid extract is administrated orally, so that the total cholesterol and low-density lipoprotein of hyperlipidaemia rats can be remarkably reduced, and the effectis close to that of a positive control drug atorvastatin calcium tablet. The extracted and purified sea cucumber flower lipid extract has a remarkable effect of reducing triglyceride in serum of the hyperlipidaemia rats, the effect of reducing triglyceride is superior to that of a positive control medicine atorvastatin calcium tablet, and meanwhile, the extracted and purified sea cucumber flower lipid extract has an obvious effect of increasing high-density lipoprotein of the hyperlipidaemia rats. The sea cucumber flower lipid extract has more remarkable blood fat regulating activity than seacucumber flowers, the effect of the sea cucumber flower lipid extract is far better than that of the sea cucumber flowers, and it is prompted that the sea cucumber flower lipid extract can be appliedto research and development of hyperlipidemia regulating drugs or health-care functional foods.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a sea cucumber imitation sea cucumber flower lipid extract and a preparation method and application thereof. Background technique

[0002] Apostichopus japonicus Selenka, also known as Liaoshen, belongs to the genus Apostichopus of the family Apostichopaceae. It is mainly produced in coastal areas such as Shandong, Liaoning, Hebei, and northern Jiangsu in my country. Sea cucumber is listed as a tonic drug in "Compendium of Materia Medica", which says it "tonifies the kidney meridian, benefits the essence, eliminates phlegm and salivation, relieves urination, strengthens yang, and treats ulcer and gangrene." Those with thorns are called sea cucumbers, and those without thorns are called light ginseng." The sea cucumber flower is the intestinal egg part of the sea cucumber. After the sea cucumber is caught, it is generally dissected immediately to remove the viscera. A long kni...

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