Sustained-release microneedle patch and preparation method thereof

A micro-needle patch and slow-release technology, applied in the field of medicine, can solve the problems of inability to make skin-piercing micro-needles, poor water solubility of materials, poor mechanical strength, etc., and achieve good skin piercing effect, sharp needle tip, and good base flexibility. Effect

Active Publication Date: 2021-03-12
BEIJING CAS MICRONEEDLE TECH LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Chinese patent CN102202720A discloses a method for preparing phase-inversion polymer microneedles by using cross-linked polyvinyl alcohol. Through repeated operations of freezing at -20°C and thawing at 4°C, water-soluble polyvinyl alcohol can be formed through microcrystal construction in aqueous solution. Gel, so as to realize the sustained release delivery of drugs, but the preparation process is cumbersome and time-consuming, which is not suitable for mass industrial production of sustained-release microneedles; and phase-change microneedles made of PLGA-PEG-PLGA triblock copolymer , the raw material synthesis process is complicated, and the material has poor water solubility, and organic reagents need to be introduced, which has potential safety hazards (Marc Pearton, Chris Allender, Keith Brain, et al. Gene Delivery to the Epidermal Cells of Human Skin Explants Using Microfabricated Microneedles an

Method used

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  • Sustained-release microneedle patch and preparation method thereof
  • Sustained-release microneedle patch and preparation method thereof
  • Sustained-release microneedle patch and preparation method thereof

Examples

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preparation example Construction

[0051] A method for preparing a slow-release microneedle patch, at least comprising the following steps:

[0052] Weighing glycerophosphate compounds and adding them into ultrapure water for dissolving to obtain glycerophosphate aqueous solution;

[0053] Weigh the non-ionic cellulose ether compound into the glycerol phosphate solution, add or not add the porogen, add or not add the active ingredient, stir and dissolve, remove the air bubbles, and obtain the needle tip preparation solution.

Embodiment 1

[0060] Follow the steps below to prepare the slow-release microneedle patch:

[0061] (1) According to the prescription of Example 1 in Table 1, use a pipette to pipette 5.525mL of ultrapure water into the centrifuge tube, use an electronic balance to precisely weigh 0.075g of sodium glycerophosphate and add it to the centrifuge tube for dissolution, then weigh 2.4 Add g hydroxypropyl cellulose into the centrifuge tube, stir, and after the solution is completely dissolved, use centrifugation to remove the air bubbles in the solution to obtain a microneedle preparation solution;

[0062] (2) Using the prepared microneedle preparation solution, adopt the PDMS mold method to prepare microneedles, and carry out negative pressure vacuum treatment on the microneedle mold through an air pump to ensure that the solution completely enters the pinholes. After completion, open the ventilation equipment to accelerate the microneedle. Needles dry to form.

[0063] Table 1 Comparative Exam...

Embodiment 2

[0066] Adopt the preparation method of Example 1 to prepare the slow-release microneedle patch, the difference is that the prescription of the microneedle preparation solution is selected from the prescription of Example 2 in Table 1, that is: ultrapure water 5.48mL, sodium glycerophosphate 0.12g, Hydroxypropylcellulose 2.4g.

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Abstract

The invention discloses a sustained-release microneedle patch and a preparation method thereof, and relates to the technical field of medicines. The microneedle patch comprises a needle body and a needle tip on the needle body, and at least the needle tip part comprises a part which is prepared from needle tip preparation liquid and can realize gelation in the drying process of the microneedle patch; and solutes of the needle tip preparation liquid comprise glycerophosphate compounds and nonionic cellulose ether compounds. The glycerophosphate and the cellulose ether compound can compete for water molecules, so that the cloud point of the cellulose ether compound is changed, the microneedle is gelatinized in the drying process, the gel microneedle with a good skin puncture effect is prepared, and in-vivo slow release of entrapped drugs is realized.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, it relates to a slow-release microneedle patch and a preparation method thereof. Background technique [0002] Sustained-release microneedle is a new type of transdermal drug delivery preparation that can achieve continuous and gentle delivery of drugs after acting in the skin. It is suitable for the use of drugs that require long-term drug administration and narrow therapeutic windows. The advantages of safety and convenience have greatly improved the medication compliance of patients, and they occupy an important position in the research of new microneedle drug delivery preparations. Existing sustained-release microneedles are mainly based on (1) sustained-release systems such as microspheres, liposomes, and solid dispersions; (2) degradable polymer materials such as polylactic acid-glycolic acid copolymers and chitosan; (3) Sol-gel phase transition materials were designed...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K45/00A61K47/24A61K47/38
CPCA61K9/0021A61K45/00A61K47/24A61K47/38A61K9/00A61K9/70A61M37/00A61K9/06
Inventor 邢梦真高云华
Owner BEIJING CAS MICRONEEDLE TECH LTD
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