Injectable antibacterial hydrogel material and preparation method thereof

A technology of hydrogel and salicylic acid, which is applied in the fields of pharmaceutical formulations, disease resistance to vector-borne diseases, and medical science. It can solve problems such as limited scope of application, complicated process flow, and complicated operation, and achieve good biocompatibility, Broad application prospects, suitable effect of swelling performance

Active Publication Date: 2021-03-12
FUJIAN NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its disadvantage is that the photodynamic effect produced by different photosensitizers has different curative effects on different types of bacterial infections, and its antibacterial effect is also related to various factors such as the mechanism of action of photosensitizers, the type of bacteria, and the growth status of bacteria.
Hydrophilic antifouling coatings have been widely used in the fields of self-cleaning, anti-fog, antifouling, oil-water separation, etc., but the process of preparing hydrophilic antifouling coatings mostly involves exp

Method used

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  • Injectable antibacterial hydrogel material and preparation method thereof
  • Injectable antibacterial hydrogel material and preparation method thereof
  • Injectable antibacterial hydrogel material and preparation method thereof

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[0034] Example

[0035] The present invention provides a method of preparing an injectable antibacterial hydrogel, including:

[0036] (a) OCS synthesis:

[0037] First, the 2 G molecular weight of 30000 da is dissolved in 200 ml 0.5 wt% dilute ice acetic acid, and then 1.325 g of sodium highiodate (NAIO) 4 ). Stirring was stirred at room temperature 24 h. Subsequently, deionized water was dialyzed for 4 days to remove unreacted small molecules naio 4 . After freeze-drying, the oxidized glycan (OCS) was stored, stored in the -20oC refrigerator.

[0038] The sample was analyzed using Fourier transform infrared spectroscopy (FT-IR). Using KBR tablets, at 25 ° C at 500 to 4000 cm −1 Measurement within the range. The result of the resulting infrared spectrum is shown in Figure 2, and the comparison can be found that the modified oxidized chitosan is 2900-3010 cm. -1 A characteristic peak of an aldehyde group occurs, and oxidated chitosan is successfully prepared.

[0039] (b) HA-ADH s...

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Abstract

The invention discloses an injectable antibacterial hydrogel material and a preparation method thereof, and relates to an antibacterial hydrogel which is composed of modified hyaluronic acid and oxidized chitosan and has injectability, good biocompatibility and tissue adhesion performance. Besides, a common bactericide hypochlorous acid is generated in the hydrogel forming process, the instant sterilization effect can be achieved, and sustainable antibiosis can be achieved through positive charges on oxidized chitosan. The antibacterial hydrogel material disclosed by the invention is convenient and rapid to prepare, does not need expensive reagents and is convenient to use.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and specifically designs an antibacterial hydrogel and its preparation method and application. Background technique [0002] Bacteria have strong adaptability and are ubiquitous in the natural environment. Bacterial infection of wounds is very common in daily life. For example, mechanical damage, unsuitable temperature and skin damage caused by chemicals. If the potentially infectious microorganisms and necrotic tissue cannot be removed in time, it is easy to be infected by bacteria. Choosing a suitable wound dressing is very important for the treatment of infection. Factors such as good hemostatic effect, good air permeability, moisture retention, comfort and flexibility are important factors for considering wound dressings. [0003] At present, there are several antibacterial strategies, including photodynamic antibacterial therapy, hydrophilic antifouling coating, metal nanomate...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L5/08A61L26/00
CPCC08J3/075C08J3/246A61L26/008A61L26/0066A61L26/0061A61L26/0023C08J2305/08C08J2405/08A61L2400/06A61L2300/232A61L2300/404A61L2300/602C08L5/08Y02A50/30
Inventor 冯茜杨雅燕肖秀峰于永生
Owner FUJIAN NORMAL UNIV
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