Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Injectable antibacterial hydrogel material and preparation method thereof

A technology of hydrogel and salicylic acid, which is applied in the fields of pharmaceutical formulations, disease resistance to vector-borne diseases, and medical science. It can solve problems such as limited scope of application, complicated process flow, and complicated operation, and achieve good biocompatibility, Broad application prospects, suitable effect of swelling performance

Active Publication Date: 2021-03-12
FUJIAN NORMAL UNIV
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is that the photodynamic effect produced by different photosensitizers has different curative effects on different types of bacterial infections, and its antibacterial effect is also related to various factors such as the mechanism of action of photosensitizers, the type of bacteria, and the growth status of bacteria.
Hydrophilic antifouling coatings have been widely used in the fields of self-cleaning, anti-fog, antifouling, oil-water separation, etc., but the process of preparing hydrophilic antifouling coatings mostly involves expensive equipment or complicated processes
In addition, the superhydrophilic surface prepared by the existing technology is easily damaged by external factors such as force, light, temperature, etc., and cannot meet the requirements of long-term use.
Metal nanomaterials have been widely used in the early stage of development, but their application range is limited due to the poor heat resistance of organic antimicrobial agents
[0004] The above-mentioned strategies all have certain limitations, such as complicated operation, release of harmful ions, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Injectable antibacterial hydrogel material and preparation method thereof
  • Injectable antibacterial hydrogel material and preparation method thereof
  • Injectable antibacterial hydrogel material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] The invention provides a preparation method of injectable antibacterial hydrogel, comprising:

[0036] (a) Synthesis of OCS:

[0037] First, 2 g of chitosan with a molecular weight of 30,000 Da was dissolved in 200 ml of 0.5 wt% dilute glacial acetic acid aqueous solution, and then 1.325 g of sodium periodate (NaIO 4 ). Stir at room temperature for 24 h in the dark. Subsequently, it was dialyzed against deionized water for 4 days to remove unreacted small molecule NaIO 4 . It was freeze-dried to obtain oxidized chitosan (OCS), which was stored in a -20ºC freezer.

[0038] The samples were analyzed by Fourier transform infrared spectroscopy (FT-IR). Using the KBr pellet method, at 25°C at 500 to 4000 cm −1 measured within the range. The obtained infrared spectrum results are shown in Figure 2. By comparison, it can be found that the modified oxidized chitosan is at 2900-3010 cm -1 The characteristic peak of aldehyde group appeared at , indicating that the oxidize...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an injectable antibacterial hydrogel material and a preparation method thereof, and relates to an antibacterial hydrogel which is composed of modified hyaluronic acid and oxidized chitosan and has injectability, good biocompatibility and tissue adhesion performance. Besides, a common bactericide hypochlorous acid is generated in the hydrogel forming process, the instant sterilization effect can be achieved, and sustainable antibiosis can be achieved through positive charges on oxidized chitosan. The antibacterial hydrogel material disclosed by the invention is convenient and rapid to prepare, does not need expensive reagents and is convenient to use.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and specifically designs an antibacterial hydrogel and its preparation method and application. Background technique [0002] Bacteria have strong adaptability and are ubiquitous in the natural environment. Bacterial infection of wounds is very common in daily life. For example, mechanical damage, unsuitable temperature and skin damage caused by chemicals. If the potentially infectious microorganisms and necrotic tissue cannot be removed in time, it is easy to be infected by bacteria. Choosing a suitable wound dressing is very important for the treatment of infection. Factors such as good hemostatic effect, good air permeability, moisture retention, comfort and flexibility are important factors for considering wound dressings. [0003] At present, there are several antibacterial strategies, including photodynamic antibacterial therapy, hydrophilic antifouling coating, metal nanomate...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J3/075C08J3/24C08L5/08A61L26/00
CPCC08J3/075C08J3/246A61L26/008A61L26/0066A61L26/0061A61L26/0023C08J2305/08C08J2405/08A61L2400/06A61L2300/232A61L2300/404A61L2300/602C08L5/08Y02A50/30
Inventor 冯茜杨雅燕肖秀峰于永生
Owner FUJIAN NORMAL UNIV
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com