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Degradable metal uterine cavity stent, release system and use method

A release system, uterine cavity technology, applied in stents, medical science, prostheses, etc., can solve the problems of re-adhesion technology, monopoly, poor medical device effect, etc., to reduce the burden of medical treatment, prevent adhesion, and stabilize mechanical support. Effect

Inactive Publication Date: 2021-03-16
UNIV OF SCI & TECH BEIJING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problems of poor effect of existing medical devices for preventing uterine adhesions, postoperative re-adhesion and foreign technology monopoly, the present invention aims to design a new type of degradable metal uterine cavity stent, release system and usage method to meet the above requirements

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  • Degradable metal uterine cavity stent, release system and use method
  • Degradable metal uterine cavity stent, release system and use method
  • Degradable metal uterine cavity stent, release system and use method

Examples

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Embodiment 1

[0026] Example 1: Structural design of a novel degradable metal intrauterine stent and its release system.

[0027] like figure 1 As shown, the device structure of the present invention includes an intrauterine stent and a release system for the treatment of uterine adhesions.

[0028] The structure of the new degradable metal uterine stent and release system is as follows: the thickness of the uterine stent is 50-100 μm. ( figure 1 ) According to the size of the human uterus, the post-expanded uterine cavity stent is 3-8 cm high, 2-5 cm wide, and 0.2-1 cm thick, and its shape conforms to the uterine cavity. The intrauterine stent consists of 1 and 2 parts ( figure 1 a), acting on the uterine cavity and the uterine horn, respectively, part 2 is connected to part 1 by welding. It can be seen from the cross-sectional view of the uterine stent ( figure 1 b), the part of the stent away from the cervix has a thicker thickness and a higher density of the support body, which can...

Embodiment 2

[0032] Example 2: Preparation of Novel Degradable Metal Uterine Stent

[0033] The preparation steps of the new degradable metal uterine branch are: selection of medical degradable metal uterine stent material→laser cutting→grinding→welding→electropolishing.

[0034] In the first step, Mg-3wt% Zn, Zn-0.8wt% Li and pure Fe tubes are selected as medical degradable metal intrauterine stent materials, the diameter of the tube is 2-5cm, and the tube thickness is 50-150μm; the yield strength of the above material is 220-400MPa, tensile strength is 350-600MPa, elongation is 20-90%.

[0035] In the second step, the selected tube is laser-cut into an intrauterine stent. After grinding, the different parts are assembled by welding. Finally, the uterine stent obtained by electropolishing is 3-8 cm high, 2-5 cm wide, and 50-150 μm thick. The radial support force of the above-mentioned degradable metal uterine stent was measured to be 15-26 kPa, which can play an effective mechanical supp...

Embodiment 3

[0036] Example 3: In vivo implantation experiment of degradable intrauterine stents in animals

[0037] Adult sexually mature female Shanghai White pigs with uterine adhesions were selected as degradable uterine stent implantation objects. According to the size of the uterus of adult female Shanghai White pigs (length 1-1.5 cm, width 1.5-3 cm), a suitable size of degradable stent was designed and prepared. Intrauterine stent and release system, the degradable stent is made of Zn-0.8Li alloy. The intrauterine stent and release system can be placed into the uterine cavity through toothless forceps in a contracted state, and then expanded into a uterine-like shape through the release system, and then removed for observation 1, 2, 3, and 6 months after implantation.

[0038] Postoperative hysteroscopic observation showed that the shape of the degradable uterine stent conformed to the uterine cavity after expansion, and formed an effective support and isolation for the uterine angl...

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Abstract

The invention discloses a novel degradable metal uterine cavity stent, a release system and a use method. The stent mainly adopts zinc and an alloy thereof, iron and an alloy thereof, and magnesium and an alloy thereof, has good strength and plasticity, can provide stable mechanical support in the service period, can be completely degraded after the service period, and does not need to be taken out through a secondary operation. Laser engraving is adopted for the stent, the thickness of the stent ranges from 50 to 150 [mu]m, and the coverage rate of the stent ranges from 10% to 20%. The shapeof the uterine cavity stent after being expanded conforms to a uterine cavity, and the expanded uterine cavity stent is 3-8cm in height, 2-5cm in width and 0.2-1cm in thickness. A slow-release medicine film on the surface of the stent contains epidermal growth factors, estrogens and antibiotic medicines, can accurately act on endometrium, reduces toxic and side effects of medicines, promotes growth of the endometrium and avoids uterine cavity infection. The release system is made of nylon or polyethylene glycol terephthalate and is free of biotoxicity, the release system can be removed after the uterine stent is expanded, no catheter is left, and bacterial infection caused by ascending from a lower genital tract is avoided. The stent and the release system can meet the use requirements ofthe human body uterine cavity stents.

Description

technical field [0001] The invention relates to a design and preparation method of a biodegradable medical device, in particular to a novel degradable metal uterine cavity stent and a release system and a use method. [0002] technical background [0003] Intrauterine adhesions refer to the mutual adhesion of the cervical canal and the uterine wall after radiation therapy, intrauterine surgery, low estrogen status, and infection caused by the destruction of the basal tissue of the endometrium and the loss of the regenerative function of the endometrium. The common causes of amenorrhea, infertility, decreased menstrual flow, periodic abdominal pain, premature birth, spontaneous abortion, and abnormal embryo implantation in women of child-bearing age have greatly endangered the reproductive rights of women of the right age and are not conducive to the current population policy in my country. At present, the method widely recognized by domestic and foreign scholars for the treatm...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61F2/958
CPCA61F2/82A61F2/958A61F2210/0004A61F2310/00083A61F2310/00041
Inventor 王鲁宁廖秦平张蕾石章智曾桢武玮李祯
Owner UNIV OF SCI & TECH BEIJING
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