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High-adhesion bi-component self-crosslinking digestive tract injury mucosa protection glue and application thereof

A high-adhesion, mucosal protection technology, applied in the field of biomedicine, can solve the problems of inability to cross-link, esophagus and intestinal parts, and achieve the effect of promoting healing, avoiding stimulation and digestion

Pending Publication Date: 2021-03-16
HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the cross-linking of this product requires an acidic environment, and cross-linking cannot occur in a non-acidic environment. It is only suitable for gastric mucosal damage and cannot be used for esophagus and intestinal tract.

Method used

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  • High-adhesion bi-component self-crosslinking digestive tract injury mucosa protection glue and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Component 1: 10 grams of oxidized sodium alginate is dissolved in 100 ml of 0.02% boric acid solution pre-suspended with 1.5 grams of magnesium lithium silicate, and the solution is completely transparent. Each bottle is packed in 10 ml. High temperature steam sterilization.

[0030] Component 2: Dissolve 2 grams of lithium magnesium silicate in 100 ml of pure water to form a transparent liquid, then add 10 grams of gelatin, 0.2 grams of beta-glucan, and 0.2 grams of calcium chloride to dissolve completely, each bottle is packed in 10ml. High temperature steam sterilization.

Embodiment 2

[0032] Component 1: 5 g of dialdehyde starch and 0.2 g of sodium alginate were dissolved in 100 ml of 0.02% boric acid solution pre-suspended with 1.5 g of magnesium lithium silicate, and the solution was completely transparent. Each bottle was packed in 10 ml. High temperature steam sterilization. Component 2: Dissolve 2 grams of lithium magnesium silicate in 100ml of pure water to form a transparent liquid, then add 3 grams of carboxymethyl chitosan, 0.2 grams of β-glucan, and 0.1 grams of calcium chloride to dissolve completely. 10ml package. High temperature steam sterilization.

Embodiment 3

[0034] Component 1: 10 grams of oxidized sodium hyaluronate and 0.5 grams of sodium alginate are dissolved in 100 ml of 0.01% boric acid solution pre-suspended with 1.5 grams of magnesium lithium silicate, and the solution is completely transparent liquid. Each bottle is packed in 10 ml. High temperature steam sterilization.

[0035] Component 2: 1.5g of lithium magnesium silicate is dissolved in 100ml of pure water to form a transparent liquid, and then 3g of hydroxypropyl chitosan, 0.2g of eryngium eryngii dextran and 0.2g of calcium chloride are added to dissolve completely. Bottle 10ml packaging. High temperature steam sterilization.

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Abstract

The invention provides high-adhesion bi-component self-crosslinking digestive tract injury mucosa protection glue and application thereof. The high-adhesion bi-component self-crosslinking digestive tract injury mucosa protection glue comprises an aldehyde group-containing high polymer biological material and an amino group-containing high polymer biological material. The two components are mixed through a double-cavity injector and then injected to the surface of a digestive tract injury mucosa through an endoscope, aldehyde groups and amino groups in the two components are crosslinked to forma colloid membrane, the aldehyde group-containing high polymer biological material is combined with protein amino groups exposed on a wound surface and firmly adheres to the wound surface, the stimulation effect of intestinal digestive juice on the digestive tract injury mucosa is avoided, and healing of the wound surface is promoted. Animal tests show that the high-adhesion bi-component self-crosslinking digestive tract injury mucosa protection glue can obviously promote repair of the injury mucosa, and therefore the high-adhesion bi-component self-crosslinking digestive tract injury mucosaprotection glue has the effects of promoting healing and protecting esophagus, stomach and intestinal tract mucosa injuries and skin wound surfaces.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a high-adhesion two-component self-crosslinking digestive tract mucosal protective glue suitable for endoscope spraying on the mucosal surface of digestive tract injury and its application. Background technique [0002] Digestive tract mucosal damage occurs from the esophagus, stomach, duodenum to rectum. Some damages are caused by diseases, while others are caused by surgery. Endoscopic gastric mucosal resection and gastric mucosal dissection are minimally invasive procedures for the resection of early gastric cancer and benign gastric tumors, which can not only achieve the purpose of radical treatment of early gastric cancer, but also have the advantages of less trauma and less impact on the quality of life of patients. Gradually replace some traditional surgical procedures. Minimally invasive surgery to remove early cancerous and benign tumors of the esophagus and colon a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/10A61L24/04A61L24/00
CPCA61L24/08A61L24/02A61L24/104A61L24/046A61L24/001A61L24/0015A61L2300/412A61L2300/416A61L2400/04A61L2300/232A61L2300/236A61L2300/252C08L5/04C08L5/02C08L3/02C08L5/08C08L77/04C08L1/284C08L1/286C08L5/00
Inventor 戴建英
Owner HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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