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Nerve repair material and preparation method thereof

A nerve repair and nerve fiber technology, applied in the field of nerve repair materials and their preparation, can solve problems such as weak effect, and achieve the effects of promoting growth, good barrier function, and preventing nerve fibers from escaping

Active Publication Date: 2021-03-26
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The outer wall of the stent prepared by these methods has a weak effect on the ingrowth of fibrous tissue around the shielded nerve stump

Method used

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  • Nerve repair material and preparation method thereof
  • Nerve repair material and preparation method thereof
  • Nerve repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] This embodiment provides a nerve repair material, the preparation method is as follows:

[0100] (1) After the fresh porcine small intestine was rinsed with clean water, the serosal layer, muscular layer, and mucosal layer were mechanically removed to obtain porcine small intestinal submucosa tissue, which was weighed with a balance. After cutting the porcine small intestinal submucosa tissue into small sections of about 10 cm, cut it into sheet materials along the axis, soak in 0.1% peracetic acid-10% ethanol solution for 3 hours, and carry out virus inactivation treatment. The weight of the soaking solution is the tissue 10 times the weight of the tissue, and then the tissue material was shaken and washed with pH=7 phosphate buffer solution for 5 times, each time for 20 minutes, and the weight of the cleaning solution was 20 times the weight of the tissue. After the tissue material was drained slightly, it was soaked in 0.03M sodium hydroxide-0.1M EDTA solution for 12...

Embodiment 2

[0108] This embodiment provides a nerve repair material, the preparation method is as follows:

[0109] (1) After the fresh porcine small intestine was rinsed with clean water, the serosal layer, muscular layer, and mucosal layer were mechanically removed to obtain porcine small intestinal submucosa tissue, which was weighed with a balance. After cutting the porcine small intestinal submucosa tissue into small sections of about 10 cm, cut it into sheet materials along the axis, soak in 0.5% peracetic acid-15% ethanol solution for 2 hours, and carry out virus inactivation treatment. 8 times the weight, and then the tissue material was shaken and washed with pH=7 phosphate buffer solution for 3 times, each time for 30 minutes, and the weight of the cleaning solution was 30 times the weight of the tissue. After the tissue material was drained slightly, it was soaked in 0.08M sodium hydroxide-0.08M EDTA solution for 18 hours to perform decellularization treatment, and the tissue m...

Embodiment 3

[0117] This embodiment provides a nerve repair material, the preparation method is as follows:

[0118] (1) After the fresh porcine small intestine was rinsed with clean water, the serosal layer, muscular layer, and mucosal layer were mechanically removed to obtain porcine small intestinal submucosa tissue, which was weighed with a balance. After cutting the porcine small intestinal submucosa tissue into small sections of about 10 cm, cut it along the axis into a sheet material, soak it in 0.8% peracetic acid-20% ethanol solution for 1 hour, and carry out virus inactivation treatment. 10 times the weight of the tissue, and then the tissue material was shaken and washed with pH=7 phosphate buffer solution for 4 times, each time for 25 minutes, and the weight of the cleaning solution was 25 times the weight of the tissue. After the tissue material was drained slightly, it was soaked in 0.15M sodium hydroxide-0.12M EDTA solution for 12 hours to perform decellularization treatment...

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Abstract

The invention relates to a nerve repair material and a preparation method thereof. The nerve repair material comprises an outer tube and an inner core matrix; the outer tube includes a multi-layer circular tube formed by curling an animal-derived acellular matrix material through vacuum pressing; and the inner core matrix includes a natural high polymer material and axially oriented micro-channelsdistributed in the natural high polymer material. The nerve repair material to which the invention relates has high biocompatibility, a good mechanical property and a a proper degradation rate; the outer tube, of a compact structure, formed by vacuum pressing has a good barrier function on surrounding fibrous tissue, and can stop ingrowth of the surrounding fibrous tissue and prevent nerve fibersfrom escaping; and the inner core matrix in which the axially oriented micro-channels are distributed provides a template for migration and proliferation of nerve cells, and orientational regeneration of nerve fibers can be guided and promoted. According to the nerve repair material, through the synergistic effect of the outer tube and the inner core matrix, formation of repaired section neuromasis reduced, and the recovery of nerve functions is promoted.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, in particular relates to a nerve repair material and a preparation method thereof, in particular to a nerve repair material capable of reducing the formation of neuromas on a repaired section, guiding and promoting directional regeneration of nerve fibers and a preparation method thereof. Background technique [0002] The repair and reconstruction of peripheral nerve defect is a major problem in the field of peripheral nerve injury. When a peripheral nerve is severed, direct anastomosis of the two broken ends cannot achieve a satisfactory functional recovery effect. Nerve fibers of different natures (sensory and motor nerve fibers) are prone to mismatch, and nerve fibers are prone to escape and connective nerve fibers at the anastomosis. issues such as tissue growth. Autologous nerve transplantation is considered to be the gold standard for repairing nerve defects, but it needs to s...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/36A61L27/24A61L27/22A61L27/20A61L27/12A61L27/50A61L27/54A61L27/56
CPCA61L27/3633A61L27/3675A61L27/3687A61L27/24A61L27/222A61L27/20A61L27/12A61L27/56A61L27/54A61L27/50A61L2300/112A61L2300/412A61L2300/252A61L2430/32C08L5/08
Inventor 梁嘉美王丹妍毛诗哲尹家瑞谭荣伟佘振定
Owner SHENZHEN LANDO BIOMATERIALS
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