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Eye drops containing pranoprofen and preparation method of eye drops

A technology for pranoprofen and eye drops, which is applied to the field of eye drops containing pranoprofen and its preparation, can solve the problems of strong irritation, general anti-inflammatory and anti-allergic effects, etc. Enhanced anti-inflammatory effect, reduced dosage effect

Inactive Publication Date: 2021-04-02
苏州工业园区天龙制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Pranoprofen eye drops are the eye drops of propionate non-steroidal anti-inflammatory drug pranoprofen. The mechanism of action is to reduce the biosynthesis of prostaglandins by inhibiting the activity of cyclooxygenase in the body. Symptomatic treatment of the front of the eye (blepharitis, conjunctivitis, keratitis, scleritis, superficial scleritis, iridocyclitis, postoperative inflammation), the strong irritation of the existing pranoprofen eye drops , anti-inflammatory and anti-allergic effects, for this reason, we propose a kind of eye drops containing pranoprofen to solve the above problems

Method used

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  • Eye drops containing pranoprofen and preparation method of eye drops

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Embodiment 1

[0025] Please refer to figure 1 As shown, the invention discloses a kind of eye drops containing pranoprofen, comprising the following raw materials in parts by weight: 0.1 part of pranoprofen, 0.1 part of sodium hyaluronate, 0.2 part of sulfobutyl ether-β-cyclodextrin 0.2 parts of stabilizing agent, 0.1 part of pH regulator, 0.3 part of antibacterial agent, 0.3 part of osmotic pressure regulator and 85 parts of water for injection.

[0026] A preparation method of eye drops containing pranoprofen, comprising the following steps:

[0027] S1. Preparation of solution 1: Weigh sulfobutyl ether-β-cyclodextrin and dissolve it in water for injection, add pranoprofen under heating at 60°C, and dissolve it completely to obtain the required solution 1;

[0028] S2, preparation of solution two: add osmotic pressure regulator, antibacterial agent and stabilizer to the solution one prepared in step S1 successively, osmotic pressure regulator is sodium chloride, drip osmotic pressure reg...

Embodiment 2

[0033] Please refer to figure 1 As shown, the invention discloses a kind of eye drops containing pranoprofen, comprising the following raw materials in parts by weight: 0.4 part of pranoprofen, 0.6 part of sodium hyaluronate, 0.4 part of sulfobutyl ether-β-cyclodextrin part, 0.3 part of stabilizer, 0.2 part of pH regulator, 0.8 part of antibacterial agent, 0.5 part of osmotic pressure regulator and 90 parts of water for injection.

[0034] A preparation method of eye drops containing pranoprofen, comprising the following steps:

[0035] S1. Preparation of solution 1: Weigh sulfobutyl ether-β-cyclodextrin and dissolve it in water for injection, add pranoprofen under heating at 60°C, and dissolve it completely to obtain the required solution 1;

[0036] S2, preparation of solution 2: Add osmotic pressure regulator, bacteriostat and stabilizer to solution 1 prepared in step S1 successively, osmotic pressure regulator is a kind of or its mixture in sodium chloride, potassium chlo...

Embodiment 3

[0041] Please refer to figure 1 As shown, the invention discloses a kind of eye drops containing pranoprofen, comprising the following raw materials in parts by weight: 0.5 part of pranoprofen, 0.7 part of sodium hyaluronate, 0.6 part of sulfobutyl ether-β-cyclodextrin part, 0.4 part of stabilizer, 0.3 part of pH regulator, 1.0 part of antibacterial agent, 0.8 part of osmotic pressure regulator and 96 parts of water for injection.

[0042] A preparation method of eye drops containing pranoprofen, comprising the following steps:

[0043]S1. Preparation of solution 1: Weigh sulfobutyl ether-β-cyclodextrin and dissolve it in water for injection, add pranoprofen under heating at 60°C, and dissolve it completely to obtain the required solution 1;

[0044] S2, preparation of solution two: add osmotic pressure regulator, bacteriostat and stabilizer to solution one prepared in step S1 successively, osmotic pressure regulator is sodium chloride, drip osmotic pressure regulator until o...

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Abstract

The invention discloses eye drops containing pranoprofen and a preparation method of the eye drops, and relates to the technical field of eye drops. The eye drops is prepared from the following raw materials in parts by weight of 0.1-0.5 part of pranoprofen, 0.1-0.7 part of sodium hyaluronate, 0.2-0.6 part of sulfobutyl ether-beta-cyclodextrin, 0.2-0.4 part of a stabilizer, 0.1-0.3 part of a pH regulator, 0.3-1.0 part of a bacteriostatic agent, 0.3-0.8 part of an osmotic pressure regulator and 85-96 parts of water for injection. According to the eye drops prepared by the invention, the sulfobutyl ether-beta-cyclodextrin and the sodium hyaluronate are added, and the sodium hyaluronate can obviously relieve clinical symptoms such as pain, itching, burning sensation, foreign body sensation ofxerophthalmia and the like, so that hyperemia caused by diseases such as blepharitis, conjunctivitis and the like can be well relieved, the effect is remarkable, and the eye drops have a wide marketprospect; and the eye drops are good in stability and free of preservatives, the dosage of anti-inflammatory drugs is reduced, and meanwhile, the anti-inflammatory effect is enhanced, and irritation to eyes is reduced.

Description

technical field [0001] The invention relates to the technical field of eye drops, in particular to an eye drop containing pranoprofen and a preparation method thereof. Background technique [0002] In recent years, due to environmental pollution, working environment, eye hygiene and other factors, the number of eye disease patients with dry eye syndrome or chronic conjunctivitis has been increasing. Ophthalmic preparations have become a necessity for many people to relieve eye inflammation and other uncomfortable symptoms. Ophthalmic inflammation accounts for a relatively large proportion of ophthalmic diseases. At present, conjunctivitis, keratitis, trachoma, blepharitis, periphthalmitis, scleritis, lacrimal gland inflammation, dacryocystitis, and corneal ulcer are common clinically. . [0003] Pranoprofen eye drops are the eye drops of propionate non-steroidal anti-inflammatory drug pranoprofen. The mechanism of action is to reduce the biosynthesis of prostaglandins by i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/436A61K31/728A61K47/36A61K47/40A61P27/02A61P29/00
CPCA61K9/0048A61K9/08A61K31/436A61K31/728A61K47/36A61K47/40A61P27/02A61P29/00A61K2300/00
Inventor 陈业仓
Owner 苏州工业园区天龙制药有限公司
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