Preparation method of mixed sugar electrolyte injection and mixed sugar electrolyte injection prepared by preparation method

Abstract

The invention provides a preparation method of a mixed sugar electrolyte injection and the mixed sugar electrolyte injection prepared by the preparation method, which relate to the technical field of medical injections. According to the preparation method, the mixed sugar, the electrolyte component, the water and the pH regulator are used as raw materials to blend the solution. The preparation method comprises the following steps of firstly, dissolving mixed sugar and electrolyte components in part of water to obtain a solution A, adding a pH regulator into the solution A, adding the balance of water, and uniformly mixing to obtain a solution B, and sequentially carrying out refined filtration, filling and sterilization on the solution B to obtain the mixed sugar electrolyte injection. According to the preparation method, high-purity nitrogen subjected to sterilization and filtration is introduced in the solution blending process, and the residual oxygen content of the solution in the blending process is controlled to be 0.01-0.2 mg / L, so that the residual oxygen content in the solution is effectively reduced, degradation of related substances in the blended solution is greatly reduced, the product is purer, and the product quality is improved.

Description

technical field [0001] The invention relates to the technical field of medical injections, in particular to a method for preparing a mixed sugar-electrolyte injection and the prepared mixed sugar-electrolyte injection. Background technique [0002] Under the invasion of various germs and during the operation period, the human body not only needs to replenish water and electrolytes, but also needs to supplement the nutritional heat source mainly sugar, so many nutritional infusion preparations have been developed. Due to the wide variety of sources of glucose and the low price, glucose-electrolyte injections currently used clinically in China are mainly glucose-sodium chloride injections. However, it is very monotonous in terms of energy supplementation and electrolyte supplementation, which cannot meet clinical needs. At the same time, for diabetics, due to the abnormal glucose tolerance of diabetics, the metabolic load after glucose injection is heavy, and glucose cannot be...

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Problems solved by technology

[0003] The prior art also discloses some preparation schemes for mixed sugar-electrolyte injections, but the residual oxygen in the solution in the existing preparation methods is relatively high, which will lead to the degradation of anhydrous glucose and fructose to produce 5-hydroxymethylfurfural; Type activated carbon is used as an adsorbent for adsorption, but activated carbon will introduce other impurities; therefore, the quality of the mixed sugar-electrolyte injection prepared by the existing scheme is poor

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