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High-stability transparent ceramide nanoemulsion gel and preparation and application thereof

A technology of ceramide and nanoemulsion, which is applied in the direction of cosmetic preparations, dressing preparations, skin care preparations, etc., can solve the problems of unclear efficacy, limitation, low transparency, etc., and achieve the effect of transparent and uniform products

Active Publication Date: 2021-04-13
RAYTING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these carriers have the defects of high emulsifier content, poor stability and unclear efficacy
[0005] In addition, most of the currently commercially available ceramide carrier systems are in the form of milky white liquids or creams. After being diluted with water, they are mostly white liquids with low transparency. They are mostly used in emulsion and cream formulations. Application in lotion, facial mask and essence

Method used

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  • High-stability transparent ceramide nanoemulsion gel and preparation and application thereof
  • High-stability transparent ceramide nanoemulsion gel and preparation and application thereof
  • High-stability transparent ceramide nanoemulsion gel and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Prepare samples according to the ratio of raw materials in Table 1, mix ceramide and solvent to obtain an oil phase, and magnetically stir in a water bath at 85°C until completely dissolved;

[0033] Mix the emulsifier and co-solvent to obtain the water phase, and heat it in a water bath at 85°C until it is completely dissolved;

[0034] Add the oil phase to the water phase, disperse at 16000rpm at high speed for 3 minutes, and then use high-pressure microchannel multiphase flow technology, 35MPa, and cycle 3 times to prepare the obtained sample.

[0035] Table 1 raw material ratio table (unit: %)

[0036]

[0037]

[0038] Note: ●: Opaque gel; ◎: Translucent gel; ○: Transparent gel

Embodiment 2

[0040] Ceramide 2: 0.2g

[0041] Ceramide 3: 0.6g

[0042] Ceramide 6: 0.2g

[0043] Hexyldecyl myristoyl carbamate: 5g

[0044] C11-14 straight chain fatty alcohol polyoxyethylene ether: 2g

[0045] Cholesterol-24: 2g

[0046] Sorbitol: 50g

[0047] Water: balance, a total of 100g

[0048] Mix ceramide and hexyldecyl myristoyl carbamate to obtain the oil phase, and magnetically stir in a water bath at 85°C until completely dissolved; mix C11-14 linear fatty alcohol polyoxyethylene ether, cholesteryl polyether- 24. Glycerin was mixed to obtain the water phase, which was heated in a water bath at 85°C until completely dissolved; the oil phase was added to the water phase, and dispersed at a high speed of 18,000 rpm for 3 minutes to obtain the primary emulsion. The first emulsion is divided into 5 parts:

[0049] (1) Using high-pressure micro-channel multiphase flow technology, 40MPa, respectively in the cycle 2 times (sample 1), 3 times (sample 2), 4 times (sample 3), 5 ...

Embodiment 3

[0059] Ceramide 2: 0.5g

[0060] Ceramide 3: 1.5g

[0061] Ceramide 6: 0.5g

[0062] PEG / PPG-dimethyl ether: 3g

[0063] Methyl perfluoroisobutyl ether:: 3g

[0064] Polyglyceryl-10 Laurate: 1g

[0065] Cholesterol-24: 3g

[0066] Polyethylene glycol: 50g

[0067] Water: balance, a total of 100g

[0068] Mix ceramide, PEG / PPG-dimethyl ether, and methyl perfluoroisobutyl ether to obtain an oil phase, and magnetically stir in a water bath at 85°C until completely dissolved; Mix glyceryl laurate and polyethylene glycol-400 to obtain a water phase, heat it in a water bath at 85°C until it is completely dissolved; add the oil phase to the water phase, disperse at a high speed of 16,000 rpm for 3 minutes, and obtain a primary emulsion. The first emulsion is divided into two parts:

[0069] (1) The transparent ceramide nanoemulsion gel was prepared by using high-pressure microchannel multiphase flow technology, 40MPa, and 4 cycles (sample 1).

[0070] (2) The transparent cer...

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Abstract

The invention discloses high-stability transparent ceramide nanoemulsion gel and preparation and application thereof. The high-stability transparent ceramide nanoemulsion gel is prepared from the following raw materials in percentage by mass: 0.1 to 5 percent of ceramide, 1 to 10 percent of solvent, 50 to 90 percent of cosolvent, 0.5 to 10 percent of emulsifier and the balance of water, wherein the total mass percentage is 100 percent. The high-stability transparent ceramide nanoemulsion gel prepared by the invention is transparent viscous liquid to transparent gel-like solid, the particle size is 10 to 50nm, and the particle size has no obvious change after the gel is placed for 6 months at -20 DEG C and 50 DEG C. The invention provides preparation of the high-stability transparent ceramide nanoemulsion gel and application of the high-stability transparent ceramide nanoemulsion gel in the field of cosmetics.

Description

technical field [0001] The invention belongs to the technical field of micro-nano carriers, and in particular relates to a high-stability transparent ceramide nano-emulsion gel and its preparation and application. Background technique [0002] Ceramide exists in all eukaryotic cells and plays an important role in regulating cell differentiation, proliferation, apoptosis, aging and other life activities. Ceramide, as the main component of intercellular lipids in the stratum corneum of the skin, not only acts as a second messenger molecule in the sphingomyelin pathway, but also plays an important role in the formation of the stratum corneum of the epidermis, has the functions of maintaining the skin barrier, moisturizing, anti-aging, whitening and disease treatment etc. [0003] In view of the special function and curative effect of ceramide on the skin, in recent years, ceramide has also rapidly become a new type of advanced cosmetic bioactive additive for skin care and hair...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/68A61K8/04A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/68A61K8/042A61Q19/00A61Q19/02A61Q19/08A61K2800/262A61K2800/413A61K2800/805
Inventor 骆晔媛梁蓉杜养标
Owner RAYTING BIOTECHNOLOGY CO LTD