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Preparation method of soluble florfenicol powder

A technology for soluble florfenicol and florfenicol, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve poor palatability, reduce animal appetite, and cannot cover up The problem of drug bitterness, etc., achieves the effect of high inclusion rate, improved bioavailability, and good inclusion effect.

Pending Publication Date: 2021-04-13
SHANDONG LUKANG SHELILE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the existing soluble florfenicol powder is processed by technology, its palatability is poor, and the bitter taste of the drug cannot be covered when eaten, which greatly reduces the appetite of animals

Method used

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  • Preparation method of soluble florfenicol powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A kind of soluble florfenicol powder, this soluble florfenicol powder is made from the raw material of following mass parts:

[0041] Florfenicol 5g, β-cyclodextrin 2g, polyethylene glycol 3g, silicon dioxide 2g, acid excipient 2g, bactericidal ingredient 2g.

[0042] Wherein, the acidic auxiliary material includes the following raw material components: 1 g of anhydrous citric acid and 1 g of anhydrous glucose.

[0043] Wherein, the composite antioxidant includes the following raw material components: 0.5 g of trimethoprim lactate and 1.5 g of sulfanilamide powder.

[0044] The preparation for soluble florfenicol powder comprises the following steps:

[0045] S101, according to the above mass parts, weigh 5 g of florfenicol, 2 g of β-cyclodextrin, 3 g of polyethylene glycol, 2 g of silicon dioxide, 2 g of acidic auxiliary materials, sterilizing Ingredients 2g;

[0046] S102, preheating the pre-prepared reactor and keeping it warm;

[0047] S103, sieve 5 g of florfen...

Embodiment 2

[0052] A kind of soluble florfenicol powder, this soluble florfenicol powder is made from the raw material of following mass parts:

[0053] Florfenicol 10g, β-cyclodextrin 3.5g, polyethylene glycol 5g, silicon dioxide 4g, acidic excipient 3.5g, bactericidal ingredient 2.5g.

[0054] Wherein, the acidic auxiliary material includes the following raw material components: 1.5 g of anhydrous citric acid and 2 g of anhydrous glucose.

[0055] Wherein, the composite antioxidant includes the following raw material components: 0.75 g of trimethoprim lactate and 1.75 g of sulfanilamide powder.

[0056] The preparation of this soluble florfenicol powder comprises the following steps:

[0057] S101, according to the above mass parts, weigh 10 g of florfenicol, 3.5 g of β-cyclodextrin, 5 g of polyethylene glycol, 4 g of silicon dioxide, and 3.5 g of acidic auxiliary materials required for the above-mentioned soluble florfenicol powder , 2.5g of sterilizing ingredients;

[0058] S102, p...

Embodiment 3

[0064] A kind of soluble florfenicol powder, this soluble florfenicol powder is made from the raw material of following mass parts:

[0065] Florfenicol 15g, β-cyclodextrin 5g, polyethylene glycol 7g, silicon dioxide 6g, acid excipient 5g, bactericidal ingredient 3g.

[0066] Wherein, the acidic auxiliary material includes the following raw material components: 2 g of anhydrous citric acid and 3 g of anhydrous glucose.

[0067] Wherein, the composite antioxidant includes the following raw material components: 1 g of trimethoprim lactate and 2 g of sulfanilamide powder.

[0068] The preparation of this soluble florfenicol powder comprises the following steps:

[0069] S101, according to the above mass parts, weigh 15 g of florfenicol, 5 g of β-cyclodextrin, 7 g of polyethylene glycol, 6 g of silicon dioxide, 5 g of acidic auxiliary materials, and sterilizing Ingredients 3g;

[0070] S102, preheating the pre-prepared reactor and keeping it warm;

[0071] S103, sieve 15 g of ...

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Abstract

The invention discloses a preparation method of soluble florfenicol powder. The soluble florfenicol powder is prepared from the following raw materials in parts by mass: 5-15 parts of florfenicol, 2-5 parts of beta-cyclodextrin, 3-7 parts of polyethylene glycol, 2-6 parts of silicon dioxide, 2-5 parts of acidic auxiliary materials and 2-3 parts of bactericidal ingredients. The florfenicol slow-release taste-masking preparation prepared by the process successfully solves the problem of poor palatability of florfenicol, masks the bitter taste of the medicine, increases the palatability, and greatly improves the appetite of animals; and according to the florfenicol slow-release taste-masking preparation, the drug florfenicol is successfully wrapped in the beta-cyclodextrin, so that the drug can be slowly released, the sustained-release effect is achieved, the drug action time is prolonged, the curative effect of the drug is improved, and the bioavailability is improved.

Description

technical field [0001] The invention relates to the field of soluble florfenicol powder, in particular to a preparation method of soluble florfenicol powder. Background technique [0002] Florfenicol is an antibiotic drug that produces a broad-spectrum antibacterial effect by inhibiting the activity of peptidyltransferase, and has a wide antibacterial spectrum, including various Gram-positive and negative bacteria and mycoplasma. Sensitive bacteria include Haemophilus of cattle and pigs, Shigella dysenteriae, Salmonella, Escherichia coli, pneumococcus, influenza bacillus, streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, etc. [0003] With the rapid development of the times, more and more people regard animals as spiritual sustenance in materialistic desires. Therefore, the health of animals is also very important to people. After the existing soluble florfenicol powder is technically processed, its palatability is poor, and the bitter taste of the me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/69A61K31/165A61P31/04
CPCA61K9/146A61K31/165A61P31/04
Inventor 谢彦军曹海峰朱元东朱学峰曹永慧刘国栋
Owner SHANDONG LUKANG SHELILE PHARMA
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