Unlock instant, AI-driven research and patent intelligence for your innovation.

Magnetic targeting photothermal therapy nano composite material and preparation method thereof

A nanocomposite material and photothermal therapy technology, which is applied in the field of magnetically targeted photothermal therapy nanocomposite materials and its preparation, can solve the problems that chemotherapy cannot meet the needs of treatment, and achieve the effect of easy characterization

Pending Publication Date: 2021-04-13
ZHEJIANG SCI-TECH UNIV
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, at the research level of anti-tumor effect, single chemotherapy can no longer meet the needs of treatment.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Magnetic targeting photothermal therapy nano composite material and preparation method thereof
  • Magnetic targeting photothermal therapy nano composite material and preparation method thereof
  • Magnetic targeting photothermal therapy nano composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for preparing magnetically targeted photothermal therapy nanocomposites, comprising the following steps;

[0031] Step 1: Take 0.3g of ferric chloride and add 40ml of water to configure ferric chloride aqueous solution, then add 3.35ml of hydrochloric acid aqueous solution with a concentration of 0.18mol / L, and after the mixed solution is fully stirred, transfer it to a preheated 100°C After fully reacting in the oven for 24h, the following figure 1 Shown Fe 2 o 3 nanomaterials;

[0032] Step 2; Fe prepared in step 1 2 o 3 Add 50ml of water to fully dissolve 50mg of nanomaterials in ultrasonic, add 0.05g of sodium citrate after dissolving in ultrasonic dispersion, then take 0.8g of cetyltrimethylammonium bromide and add 30ml of water in a 30°C water bath to fully dissolve and stir, after fully stirring Join Fe 2 o 3 Add 0.2ml of diethanolamine to the aqueous solution, mix and stir evenly at a constant rate, and finally put it in a 60°C oil bath, add 10ml o...

Embodiment 2

[0038] Step 1: Take 0.3g of ferric chloride and add 40ml of water to make an aqueous solution of ferric chloride, then add 5ml of aqueous hydrochloric acid solution with a concentration of 0.18mol / L, stir the mixed solution evenly, and transfer it to an oven preheated at 100°C Fully react in 24h, that is, Fe 2 o 3 nanomaterials;

[0039] Step 2; Fe prepared in step 1 2 o 3 Add 50ml of water to fully dissolve 50mg of nanomaterials in ultrasonic, add 0.05g of sodium citrate after dissolving in ultrasonic dispersion, then take 0.8g of cetyltrimethylammonium bromide and add 30ml of water in a 30°C water bath to fully dissolve and stir, after fully stirring Join Fe 2 o 3 Add 0.2ml of diethanolamine to the aqueous solution, mix and stir evenly at a constant rate, and finally put it in a 60°C oil bath, add 5ml of cyclohexane and 0.1ml of tetraethyl orthosilicate mixed solution with magnetic stirring for reaction, and react for 24h. Afterwards, the core-shell structure Fe 2 o ...

Embodiment 3

[0044] A nano-composite material for magnetically targeted photothermal therapy, prepared by the following steps:

[0045] Step 1: Take 0.3g of ferric chloride and add 40ml of water to configure ferric chloride aqueous solution, then add 3.35ml of hydrochloric acid aqueous solution with a concentration of 0.18mol / L, and after the mixed solution is fully stirred, transfer it to a preheated 100°C Fully react in the oven for 24 hours to obtain Fe 2 o 3 nanomaterials;

[0046] Step 2; Fe prepared in step 1 2 o 3 Add 50ml of water to 50mg of nanomaterials to fully ultrasonically disperse. After dissolving, add 0.05g of sodium citrate during ultrasonic dispersion, then take 0.8g of cetyltrimethylammonium bromide and add 30ml of water to 30°C water bath to fully dissolve and stir. After fully stirring Join Fe 2 o 3 Add 0.2ml of diethanolamine to the aqueous solution, mix and stir evenly at a constant rate, and finally put it in a 60°C oil bath, add 10ml of cyclohexane and 0.1ml...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a magnetic targeting photothermal therapy nano composite material and a preparation method thereof. The method comprises the following steps of: taking Fe2O3 as a core material, forming Fe2O3@mSiO2 composite microspheres with a core-shell structure by a one-step hydrothermal method, further growing Au particles on the surface of the Fe2O3@mSiO2, and finally preparing magnetic Fe3O4@mSiO2@Au nano composite microspheres, namely the magnetic targeting photothermal therapy nano composite material, by a calcination strategy. The material provided by the invention has magnetism, so that the material can be magnetically targeted to a specific part under the physical induction action of a magnetic field, and the damage to other organs in the treatment process is reduced; mesoporous silica in the middle layer of the magnetic targeting photothermal therapy nano composite material serves as a protective shell of a magnetic core; and in addition, the mesoporous structure provides rich sites for loading and embedding of the Au particles, and the Au nano particles on the outermost layer of the composite material can serve as a good photothermal agent for photothermal therapy.

Description

technical field [0001] The invention relates to the field of nanometer material preparation. More specifically, it relates to a nanocomposite material for magnetically targeted photothermal therapy and a preparation method thereof. Background technique [0002] In recent years, anticancer treatment has become a research hotspot of many medical researchers at home and abroad. Among them, chemotherapy has become the most conventional treatment for cancer because anticancer drugs act on the cellular level. However, drug molecules spread all over the body, inevitably causing damage to normal tissue cells, bringing toxic side effects and reducing curative effect at the same time. However, with the advancement of science and the intersection of different disciplines, smart medical care is booming, and the research on new sustained and controlled release drug delivery technology has gradually become an important topic in cancer treatment. At present, at the research level of ant...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K9/0009A61P35/00
Inventor 陈冠政钱矜辰程琳
Owner ZHEJIANG SCI-TECH UNIV