A kind of bowl-shaped ISP composite functional nanoparticles and its preparation method and application
A composite nanoparticle and nanoparticle technology, applied in the field of nanosystems, can solve the problems of limiting the development of photodynamic therapy, toxic and side effects of healthy tissues, limiting the activity of photosensitizers, etc., and achieve good catalytic ability, efficient treatment, and improve the activity of photosensitizers Effect
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Embodiment 1
[0044] Preparation of bowl-shaped PEG-b-PS: PEG-b-PS block polymer according to figure 2 Synthesis as shown, specifically, poly(ethylene glycol) monomethyl ether (6.00 g, 2.00 mmol) with a molecular weight of 3000 was dissolved in 20 mL of tetrahydrofuran uniformly, then triethylamine (1.04 mL, 7.5 mmol) was added, and the mixture was cooled at 0°C on ice 2-Bromoisobutyryl bromide (620 μL, 5.00 mmol) was added dropwise under a water bath and nitrogen protection for 24 hours. After the reaction, suction filtration to obtain a white precipitate, and vacuum drying to obtain PEG-Br. PEG-Br was dissolved in 1.5ml anisole, and CuCl (45mg, 0.45mmol) and PMDETA (α-bromoisobutyrate, N,N,N',N",N"-Pentamethyldiethylenetriamine, 66μL were added under anhydrous and anoxic conditions. 0.32 mmol), anhydrous and oxygen-free reaction at 90 °C for 12 hours, in an argon atmosphere during the feeding period, and the low temperature state of the raw materials is maintained by placing the reactio...
Embodiment 2
[0046] superparamagnetic Fe 3 O 4 Nanoparticle preparation: 1.42g Fe(acac) 3 After dissolving evenly in 50 mL of triethylene glycol, N 2 Under the protection, gradient heating was carried out from room temperature to 200 °C, then to 250 °C, and finally to 280 °C. Each stage was kept stable for 10 min, and the reaction was carried out at 280 °C for 0.5 h to obtain superparamagnetic Fe. 3 O 4 Nanoparticle triethylene glycol solution. prepared Fe 3 O 4 Electron microscope image of nanoparticles Figure 4 shown.
Embodiment 3
[0048] ZnPc synthesis: Synthesis of side-chain tetra-substituted benzoic acid sodium salt phthalocyanine derivatives Figure 5 Follow the steps shown. p-Hydroxybenzoic acid (500 mg, 3.62 mmol) and 4-nitrophthalonitrile (658 mg, 3.8 mmol) were dissolved in N,N-dimethylformamide (8 mL), potassium carbonate (561.2 mg, 4.06 mmol) In mixed solvent, N 2 Under the protection conditions, the reaction generated compound 1; compound 1 (500 mg, 1.89 mmol) and zinc acetate (217 mg, 1.18 mmol) were catalyzed by DBU (0.38 mL, 2.82 mmol), and reacted in n-amyl alcohol (8 mL) solution at 140 ° C for 12 h , to generate compound 2; compound 2 (200 mg, 0.18 mmol) was reacted with sodium hydroxide (16 mg, 0.4 mmol) in ethanol (10 mL) for 24 h to finally generate a side-chain tetra-substituted benzoic acid sodium salt phthalocyanine derivative (ZnPc).
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