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Extraction process of salidroside

A technology of salidroside and extraction process, which is applied in the direction of physical/chemical process catalysts, organic compounds/hydrides/coordination complex catalysts, sugar derivatives, etc., and can solve problems such as the inability to obtain pure salidroside, Achieve the effect of convenient recycling, improving purity and saving production cost

Active Publication Date: 2021-04-13
湖州柳荫生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a large proportion of salidroside, aglycone tyrosol and rhodiola in the rhodiola extract have hydroxyl groups that can be bonded, and the application of existing magnetic materials to adsorb cannot obtain high-purity rhodiola. Sedroside

Method used

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  • Extraction process of salidroside
  • Extraction process of salidroside
  • Extraction process of salidroside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The process of extracting salidroside in the present embodiment is as follows:

[0038] 1. Preparation of Magnetic Particles

[0039](1) Weigh 3.46g of ferric chloride hexahydrate and place it in 70ml of ethylene glycol, slowly add 7.66g of anhydrous sodium acetate, stir vigorously at room temperature for 30min until it is completely dissolved, and obtain a uniform yellow solution, then dissolve the solution Transfer to a Teflon-lined stainless steel high-pressure reactor, react at 200 degrees Celsius for 12 hours, and obtain a black precipitate, wash with absolute ethanol for 3 times and then with deionized water for 3 times, and vacuum-dry at 60 degrees Celsius for 12 hours to obtain ferric oxide particles ;

[0040] (2) Weigh 200mg of ferric oxide particles that have been prepared and add them to a solution containing 100ml of ethanol / water (4 / 1, v / v) and 2ml of ammonia water (mass concentration 28%), sonicate for 30min, add 2ml of TEOS (positive Ethyl silicate), s...

Embodiment 2

[0053] The difference between this embodiment and embodiment 1 is that pdI 2 (Ph 3 P) 3 - THF solution replaced by pdCl 2 (Ph 3 P) 2 -DMSO solution; the extraction steps of salidroside are:

[0054] (1) Take 50mg of magnetic particles and add them to 5ml of Rhodiola rosea extract, mix and incubate, shake on a vortex shaker for 10 minutes, then place in a strong magnetic field to attract, remove the supernatant, and take out the magnetic particles;

[0055] (2) Rinse the magnetic particles taken out in step (1) with 5ml of absolute ethanol, oscillate on a vortex oscillator for 10 minutes, place in a strong magnetic field to attract, remove the supernatant, take out the magnetic particles, and repeat twice;

[0056] (3) Soak the magnetic particles taken out in step (2) in 5ml of sodium acetate-acetic acid-ethanol solution with pH=3.6, oscillate ultrasonically for 20min, then add 5ml70% ethanol solution, oscillate ultrasonically for 30min, in the obtained system, The clear ...

Embodiment 3

[0060] The difference between this embodiment and embodiment 1 is that pdI 2 (Ph 3 P) 3 - THF solution replaced by NiCl 2 (Ph 3 P) 2 - DMF solution.

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Abstract

The invention relates to an extraction process of salidroside. The extraction process comprises: 1, carrying out mixed incubation on a rhodiola rosea extract and magnetic particles to obtain a mixed solution a; 2, attracting and separating the mixed solution a through a magnet or in a magnetic field, and obtaining adsorption magnetic particles b; 3, soaking the adsorption magnetic particles b in an eluent A and then attracting and separating through a magnet or in a magnetic field, and obtaining fishing liquid c and elution magnetic particles d; 4, acetylating the fishing liquid c, mixing the acetylated fishing liquid c with penta-acetyl glucose, adding the eluted magnetic particles d, and carrying out a reaction to generate a reactant e; and 5, carrying out deacetylation treatment on the reactant e to obtain salidroside, wherein the magnetic particles are prepared by immobilizing a nickel or palladium complex on the surfaces of magnetic silicon dioxide material particles by tyramine. The magnetic materials are used for carrying out solid-phase adsorption on the extract, so that the extraction rate is high. Meanwhile, in the subsequent process, a magnetic material is used for catalyzing non-target substances to be converted into salidroside, so that the purity of salidroside is improved.

Description

technical field [0001] The invention belongs to the technical field of salidroside extraction, and in particular relates to a salidroside extraction process. Background technique [0002] Rhodiola (Rhodiola) is a perennial herb or subshrub belonging to Rhodiola in the Sedum family. It is one of the rare medicinal plants and is known as "Plateau Ginseng". There are about 90 species of this genus in the world, and more than 70 species are distributed in my country, mainly in North China, Northeast China, Southwest China, Northwest China and Central China. Its chemical components mainly include flavonoids, tyrosol, salidroside, sitosterol, organic acids, volatile oil, polysaccharide, fat, protein, etc. Among them, salidroside and its aglycone tyrosol are the main active ingredients of Rhodiola rosea, and they are also the most important indicators for evaluating Rhodiola rosea and its extracts. Modern pharmacological studies have confirmed that Rhodiola extract has anti-aging...

Claims

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Application Information

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IPC IPC(8): C07H15/18C07H1/08C07H1/00B01J31/24
CPCC07H15/18C07H1/00C07H1/08B01J31/1658B01J31/2404B01J2531/847B01J2531/824B01J35/33Y02E50/10
Inventor 柳秦桥费舒堂
Owner 湖州柳荫生物科技有限公司
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