Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Quality control method of loquat leaf lung-moistening cough-relieving paste

A quality control method, a technique for moistening the lung and relieving cough, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., and can solve the problems of speculation by lawbreakers, the simple detection method of lotus leaf moistening lung and cough ointment, and not being well suitable for clinical requirements, etc.

Pending Publication Date: 2021-04-20
GUIZHOU MAQIKA PHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing detection method of Loquat Leaf Runfei Zhike Ointment is simple, and only identifies or detects a class of ingredients (alkaloids) in the ingredients of traditional Chinese medicine, which cannot effectively control the internal quality of the product.
For example, in the 03 issue of Guizhou Medicine in 2008, in the paper "Determination of the Content of Ephedrine Hydrochloride in Loquat Leaf Runfei Zhike Ointment by High Performance Liquid Chromatography" published by our company, only this component of ephedrine was detected alone. It is not possible to effectively control the internal quality of the product, and it is still easy to bring opportunistic opportunities to criminals. Substituting other medicinal materials for the medicinal materials specified in the prescription will seriously affect the vital interests of patients. Therefore, the produced products are controlled according to the existing quality standards. None of the products are well suited to clinical requirements

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quality control method of loquat leaf lung-moistening cough-relieving paste
  • Quality control method of loquat leaf lung-moistening cough-relieving paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Identification of Loquat Leaf in Loquat Leaf Runfei Zhike Ointment

[0031] Take 20 mL of loquat leaf moistening lung and cough ointment, add 50 mL of hot water to it to dissolve, then add 2 mL of hydrochloric acid to it, shake well, and use it as the test solution; take 1.5 g of loquat leaf control medicinal material, add 50 mL of water, decoct for 1 h, Combine the filtrates, filter, put in a separatory funnel, add 2 mL of hydrochloric acid, shake well, then extract with 25 mL of n-butanol saturated with water, separate the n-butanol liquid, concentrate and evaporate to dryness, add 1 mL of methanol to dissolve the residue, and use it as a reference drug solution; According to the thin-layer chromatography test, draw 10 μL of the test solution and 10 μL of the reference medicinal material solution, and place them on the same silica gel G thin-layer plate respectively, with cyclohexane-chloroform-ethyl acetate-glacial acetic acid (20:5: 8:0.5) as developing a...

Embodiment 2

[0033] Example 2: Identification of Aster in Paye Runfei Zhike Ointment

[0034] Take 20 mL of Loquat Leaf Runfei Zhike Ointment, add 30 mL of petroleum ether at 60-90 ° C to it, heat and reflux for 30 minutes, filter, and the filtrate is concentrated to 1 mL as the test solution; Methane was 20mL, ultrasonically filtered for 15min, the filtrate was concentrated to 5mL, and used as the reference medicinal material solution; according to the thin-layer chromatography test, 10 μL of the test solution and 10 μL of the reference medicinal material solution were drawn, respectively, on the same silica gel G thin-layer plate, with 60- Petroleum ether-ethyl acetate (9:1) at 90°C was used as developing agent, developed, taken out, dried in the air, sprayed with dinitrophenylhydrazine solution, heated at 105°C for 10min, until the spots were clearly colored; Among them, at the position corresponding to the chromatogram of the control medicinal material, yellow spots of the same color a...

Embodiment 3

[0036] Example 3: Identification of Ephedra in Paye Runfei Zhike Ointment

[0037]Take 10 mL of Loquat Leaf Runfei Zhike Ointment, add 20 mL of methanol to it, ultrasonicate for 15 minutes, filter while hot and evaporate to dryness, add 4 mL of methanol to the residue to dissolve it completely, and use it as the test solution; The method is prepared as a reference medicinal solution; according to the thin-layer chromatography test, 10 μL of the test solution and 10 μL of the reference medicinal solution are drawn, and they are respectively spotted on the same silica gel G thin-layer plate, and mixed with n-butanol-methanol-chloroform-ammonia ( 8:1:3:1) as developing agent, develop, take out, dry, spray with ninhydrin solution, heat at 105°C for 5min, until the spots are clearly colored; At the position, the main spot of the same color appears under sunlight.

[0038] Conclusion: According to the above operation method, the test spots of Paye Runfei Zhike Cream are consistent ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a quality control method of loquat leaf lung-moistening cough-relieving paste, and relates to the technical field of traditional Chinese medicine quality detection. The method comprises identification of loquat leaves, identification of aster tataricus, identification of ephedra and determination of ephedra content. Thin-layer chromatography identification is carried out on three main components including loquat leaves, aster tataricus and ephedra in the loquat leaf lung-moistening cough-relieving paste, and meanwhile, and the contents of effective components including ephedrine hydrochloride and pseudoephedrine hydrochloride in the traditional Chinese medicinal material ephedra are measured, so that the product quality can be effectively controlled, the product curative effect is guaranteed, and great central excitation side effects of people are not easy to generate.

Description

technical field [0001] The invention relates to the technical field of quality detection of traditional Chinese medicines, in particular to a quality control method of Loquat Leaf Runfei Zhike Ointment. Background technique [0002] Loquat Leaf Moisturizing Lung and Cough Ointment consists of loquat leaf, aster, fritillary fritillary, perilla seed, bitter almond, pinellia chinensis, poria cocos, tangerine peel, asparagus, mustard seed, sand ginseng, coltsfoot flower, aurantium husk, melon wilt It is composed of 18 medicinal materials, including seed, Peucedanum, perilla leaf, licorice, and platycodon. The existing Loquat Leaf Runfei Zhike Ointment has a simple detection method, which only identifies or detects a class of components (alkaloids) in the components of traditional Chinese medicines, and cannot effectively control the internal quality of the product. For example, in the 03 issue of Guizhou Medicine in 2008, in the paper "Determination of the Content of Ephedrine ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/90G01N30/94G01N30/74
Inventor 张涛涛何利华
Owner GUIZHOU MAQIKA PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com