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Medicine for preventing thrombus formation or formed thrombus dissolution and preparation method of medicine

A drug and thrombus technology, applied in the field of medicine, can solve problems such as large side effects

Pending Publication Date: 2021-05-07
HANGZHOU KEBEIAN BIOPHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the currently available treatment of thrombotic diseases has the above-mentioned multiple treatment options, these treatment options of platelet inhibitors, anticoagulation and activation of fibrinolytic reaction and then thrombolysis have relatively large side effects, especially the most important one in thrombolytic therapy. complication is bleeding

Method used

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  • Medicine for preventing thrombus formation or formed thrombus dissolution and preparation method of medicine
  • Medicine for preventing thrombus formation or formed thrombus dissolution and preparation method of medicine
  • Medicine for preventing thrombus formation or formed thrombus dissolution and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The extraction and separation of embodiment 1 compound combination

[0049] A preparation method for preventing thrombus formation in mammalian blood and capable of dissolving thrombus formed in blood, comprising the following steps:

[0050] 1. Wash, dry and cut the whole blue cloth grass collected at an altitude of 1000-1400 meters in Qianxinan Buyi and Miao Autonomous Prefecture, Guizhou Province in September 2020.

[0051] 2. Reflux the dried pieces of blue cloth (2 kg) with 8 times of petroleum ether to extract for 8 hours, and recover the petroleum ether. The extract mainly contains fat-soluble substances that cannot prevent thrombosis and have not dissolved in the blood. Thrombotic activity, and hepatotoxic compounds, therefore discarded;

[0052] 3. The blue cloth raw material extracted with petroleum ether was reflux extracted with 10 times the concentration of 60% ethanol for 8 hours, the ethanol extract was concentrated and spray-dried into a solid powder to...

Embodiment 2

[0057] The effect of embodiment 2 compound combination on mouse coagulation time (CT)

[0058] Male experimental mice with a basic physiological coagulation time of 40-160S were selected for the experiment, and grouped based on the uniform distribution of coagulation time. randomly divided into;

[0059] Group 1. (n=15) normal group, 0.5% sodium carboxymethylcellulose (CMC—Na) solution;

[0060] 2 groups. (n=15) positive control group, 20mg / kg aspirin;

[0061] Group 3. Administration groups were given 200, 400, 600 mg / kg body weight active combination respectively. All groups were administered orally, once a day. The number of animals in the three dosage groups of the administration group was 15.

[0062] Animals in the three groups were given the above-mentioned oral treatment continuously for 3 days. One hour after the last administration of the corresponding oral treatment, a glass capillary tube with an inner diameter of 1 mm was inserted into the venous plexus of the...

Embodiment 3

[0068] The impact of embodiment 3 compound combination on experimental animal bleeding time

[0069] Kunming male mice were randomly divided into 3 groups.

[0070] Group 1. (n=8) normal group, 0.5% carboxymethylcellulose sodium (CMC—Na) solution;

[0071] 2 groups. (n=8) positive control group, 20mg / kg aspirin;

[0072] Group 3. Administration groups were given 200, 400, and 600 mg / kg active combination respectively. All groups were administered orally, once a day. The number of animals in the three dosage groups of the administration group was 8.

[0073] Experimental animals in each group were administered orally once a day for 3 consecutive days. One hour after the last administration, the mice were taken out and placed in a fixer so that the tail was vertical, cut off at 1.5 mm from the tip of the tail, and sucked blood with filter paper until Until the blood can't be sucked. Record the time from docking the tip of the tail to no bleeding as the tail bleeding time. ...

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Abstract

The invention discloses a medicine for preventing thrombus formation or formed thrombus dissolution and a preparation method of the medicine, and belongs to the field of medicines. The medicine comprises a herba gei active compound combination, wherein the herba gei active compound combination is separated from herba gei extraction, potential hepatotoxic compounds are removed, and the herba gei active compound combination comprises polyphenol compounds and / or pentacyclic triterpenoids. When the medicine is given to a tested mammal, thrombus formation can be prevented and formed thrombus can be dissolved in blood of the mammal. The medicine mainly inhibits thrombus formation in blood and dissolves formed thrombus through a synergistic effect with blood coagulation factors / fibrinolytic factors in blood, so that different diseases or disease states caused by thrombus formation and thromboembolism in different tissues or organs are prevented and treated.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a medicine for preventing thrombus formation or dissolving formed thrombus and a preparation method thereof. Background technique [0002] Thromboembolic disease includes thrombosis and embolism, which can occur anywhere in the blood circulation in arteries, capillaries, or veins. If the blood coagulates in any part of the blood circulation to form a blood clot, it is called thrombosis; if the formed thrombus breaks away from its original position and blocks other parts of the distal end along the blood flow, it is called embolism. [0003] Vascular endothelial injury, platelet activation and aggregation and other factors can lead to increased blood coagulation, and even start the coagulation process, promoting thrombus formation. The reduction of fibrinolytic activity in the human body, such as abnormal plasminogenemia, can lead to a decrease in the ability of the human body...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P7/02A61P9/14
CPCA61K36/73A61K2236/35A61P7/02A61P9/14
Inventor 李明梅丽萍
Owner HANGZHOU KEBEIAN BIOPHARMACEUTICAL CO LTD
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