A kind of degradable polycarbonate polyurethane containing ditellurium and preparation method thereof

A technology of polycarbonate and polyurethane, applied in the direction of extracellular fluid diseases, antiviral agents, drug combinations, etc., can solve the problems of inability to respond intelligently, limit applications, etc., achieve controllable structure, reduce activation and adhesion, and good anti-inflammation The effect of action

Active Publication Date: 2022-02-01
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But on the other hand, due to its own structure, most polyurethane materials are often unable to achieve intelligent response to the service environment, which greatly limits its wider application.

Method used

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  • A kind of degradable polycarbonate polyurethane containing ditellurium and preparation method thereof
  • A kind of degradable polycarbonate polyurethane containing ditellurium and preparation method thereof
  • A kind of degradable polycarbonate polyurethane containing ditellurium and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of ditellurium-containing polycarbonate polyurethane (PCU-TeTe):

[0029]

[0030] Step 1. Pre-dewater 1,6-hexanediol polycarbonate diol (PCDL, 5g, 1kDa) at 100°C for 3h under vacuum, and add 2.56g of MDI to the reaction containing PCDL under the protection of argon. In the device, stir at 60°C for 2 hours to obtain a prepolymer;

[0031] Step 2. Weigh 1.75g ​​of ditelluridediethanol and dissolve it in 80ml of dry N,N-dimethylacetamide (DMAc), inject the solution into the reactor with a syringe, mix it with the prepolymer evenly, and then add 1 ‰ of stannous octoate. After continuing to stir and react at 70°C for 10 hours, slowly transfer the reaction solution to 1L of methanol for precipitation, and repeatedly wash the solid with methanol and ethanol for 2 to 3 times, then dry it in a vacuum oven to obtain ditellurium-containing polycarbonate Polyurethane, and named PCU-TeTe.

[0032] According to the method described in step 1 and step 2, an equivalent...

Embodiment 2

[0048] Preparation of ditellurium-containing polycarbonate polyurethane (PCU-I-TeTe):

[0049]

[0050] Step 1. Pre-dewater 1,6-hexanediol polycarbonate diol (PCDL, 5g, 1kDa) at 100°C for 3h under vacuum. Under the protection of argon, add 2.67g IPDI to the reaction containing PCDL In the device, stir at 60°C for 2 hours to obtain a prepolymer;

[0051] Step 2. Weigh 1.75g ​​of ditelluridediethanol and dissolve it in 80ml of dry DMAc, inject the solution into the reactor with a syringe, mix it with the prepolymer evenly, and then add 2‰ of stannous octoate. After continuing to stir and react at 70°C for 8 hours, slowly transfer the reaction solution to 1L of methanol for precipitation, wash the solid with methanol and ethanol for 2 to 3 times, and then dry it in a vacuum oven to obtain ditellurium-containing polycarbonate Polyurethane, and named PCU-I-TeTe.

Embodiment 3

[0053] Preparation of ditellurium-containing polycarbonate polyurethane (PCU-HM-TeTe):

[0054]

[0055] Step 1. Pre-dewater 1,6-hexanediol polycarbonate diol (PCDL, 10g, 2kDa) at 100°C for 3h under vacuum, and add 2.68g of HMDI to the reaction containing PCDL under the protection of argon. In the device, stir at 60°C for 2 hours to obtain a prepolymer;

[0056] Step 2. Weigh 1.75g ​​of ditelluridediethanol and dissolve it in 120ml of dry DMAc, inject the solution into the reactor with a syringe, mix it with the prepolymer evenly, and then add 3‰ of stannous octoate. After continuing to stir and react at 70°C for 7 hours, slowly transfer the reaction solution to 1L of methanol for precipitation, wash the solid with methanol and ethanol for 2 to 3 times, and then dry it in a vacuum oven to obtain ditellurium-containing polycarbonate Polyurethane, and named PCU-HM-TeTe.

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Abstract

The invention discloses a ditellurium-containing degradable polycarbonate polyurethane and a preparation method thereof. The ditellurium-containing polycarbonate polyurethane molecular chain contains -Te-Te-groups and has repeating units of the following structure: Or wherein: m and n are any integers from 2 to 8; T is a chain segment of polycarbonate diol; G is a structural unit of diisocyanate. The structure of the degradable polycarbonate polyurethane containing ditellurium provided by the present invention is controllable, the tellurium content is adjustable, and the molecular structure of the obtained polymer is determined; in the present invention, ditellurium diol or ditellurium diamine is used as a chain extender The ditellurium group was introduced into the polymer main chain, and the prepared polymer has redox responsiveness, good ability to scavenge oxygen free radicals and anti-inflammatory effect at the same time.

Description

technical field [0001] The invention relates to the technical field of ditellurium-containing polymers, in particular to a ditellurium-containing degradable polycarbonate polyurethane and a preparation method thereof. Background technique [0002] In recent years, cardiovascular disease has become the number one killer threatening human life and health. Among conventional treatment methods, taking and injection of drugs, interventional therapy, etc. have become effective means and are widely used by people. The interventional treatment methods often require people to modify the intervention materials to ensure special effects such as anti-inflammation, anti-coagulation and scavenging oxygen free radicals. [0003] Tellurium is a metalloid existing in the periodic table of elements, and studies have shown that the bond energy of the ditellurium bond is only 126kJmol -1 , this feature gives ditellurium bonds many unique properties. In recent years, Xu Huaping's research gro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/66C08G18/44C08G18/32C08G18/10A61P39/06A61P29/00A61P7/02
CPCC08G18/44C08G18/10A61P39/06A61P29/00A61P7/02C08G18/3897
Inventor 赵元聪李培闯王进周磊李欣王锐陈航王克兵
Owner SOUTHWEST JIAOTONG UNIV
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