Unlock instant, AI-driven research and patent intelligence for your innovation.

Asarone nanometerization method

A kind of asarone and nanotechnology, which is applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of difficult dissolution and low bioavailability of oral preparations of asarone, and achieve the improvement of bioavailability in vivo and the preparation process Simple, small particle size effect

Active Publication Date: 2022-04-08
GUILIN PHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of asarone nanometerization method, improve the solubility and dissolution rate of asarone through nanotechnology, solve the problem of difficult dissolution and low bioavailability of asarone oral preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Asarone nanometerization method
  • Asarone nanometerization method
  • Asarone nanometerization method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The nanometerization method of asarone

[0027] Weigh 0.250g of polyethylene glycol 15-hydroxystearate and 0.250g of polyvinyl alcohol, place them in a beaker, add about 50g of water to dissolve them completely, and prepare an aqueous stabilizer solution. Weigh 0.500g of asarone crude drug, place it in a 10mL sample bottle, add 5g of polyethylene glycol 400, shake to dissolve the drug, and make an organic phase. Under the conditions of probe ultrasound (2s on, 3s off), the parameters of ultrasound are power 60W, time 5min, absorb the organic phase with a dropper and add it into the stabilizer aqueous solution at a uniform speed to obtain the asarone nano-scale colloidal dispersion. The particle size measured by the laser particle size analyzer is 119.37nm, and the PDI is 0.261, see figure 1 .

Embodiment 2

[0029] Effects of Probe Ultrasonic Power and Time on the Size of Asarone Nanoparticles

[0030] Weigh 0.050g of polyethylene glycol 15-hydroxystearate and 0.050g of polyvinyl alcohol, place them in a beaker, add about 50g of water to dissolve them completely, and prepare an aqueous stabilizer solution. Weigh 0.050g asarone crude drug, place in a 10mL sample bottle, add 5g polyethylene glycol 400, shake to dissolve the drug, and make an organic phase.

[0031] (1) Ultrasonic power

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for nano-asarone, which belongs to the technical field of pharmaceutical preparations. The nanometerization method adopts an anti-solvent precipitation method, first dissolving the asarone in an organic solvent, and then mixing it with an aqueous solution of a stabilizer, so that the asarone is supersaturated and precipitated to form a stable nano-scale colloid dispersion. The invention improves the solubility and the dissolution rate of the asarone through the nanometerization technology, and solves the problems of difficult dissolution and low bioavailability of the asarone oral preparation.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a method for nanometerization of asarone. Background technique [0002] Asarone (Asarone, ARE) is one of the main active ingredients in the rhizomes of plants such as Chinese medicine Shichangpu, also known as α-asarone and asarone, and its chemical name is 2,4,5-trimethoxy-1- Propylbenzene, molecular formula C 12 h 16 O, relative molecular mass 208.26. Asarone is soluble in ethanol, ethyl acetate, chloroform and ether, but hardly soluble in water. A large number of studies have proved that asarone has multiple pharmacological effects such as expectorant, bronchial smooth muscle relaxation, central sedation, anticonvulsant, antibacterial and anti-inflammatory, anticancer and blood lipid lowering. [0003] Currently, the clinically available asarone dosage forms are tablets, capsules and injections, which are commonly used in the treatment of pn...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/09A61K47/38A61K47/32A61K47/10A61K47/14A61K47/20A61P11/10A61P11/08A61P35/00A61P31/04A61P3/06A61P25/20A61P25/08B82Y5/00
CPCA61K31/09A61K47/38A61K47/32A61K47/10A61K47/14A61K47/20A61P11/10A61P11/08A61P35/00A61P31/04A61P3/06A61P25/20A61P25/08B82Y5/00
Inventor 蒋曙光尹赛楠赵新宇
Owner GUILIN PHARMA