Reduction and pH super-sensitive cross-linked polymer prodrug and preparation method and application of polymer prodrug

A technology of cross-linking polymers and polymers, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of capillary hyperplasia, which is difficult to supply sufficient oxygen and nutrients. question
CN112807441AActive Publication Date: 2021-05-18ANHUI UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ANHUI UNIVERSITY
Publication Date
2021-05-18

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Abstract

The invention discloses a reduction and pH super-sensitive cross-linked polymer prodrug, relates to the technical field of controllable cross-linked polymer prodrugs, and the structural formula of the polymer prodrug is shown as a formula III. The invention also provides a preparation method and application of the polymer prodrug. The cross-linked polymer disclosed by the invention has the beneficial effects that the cross-linked polymer is compact in structure and not easy to disintegrate in a blood circulation process; extracellular orthoester is degraded at a tumor part, the particle size is increased, and the retention effect is enhanced; after the cross-linked polymer is taken by cells, the medicine is quickly released in glutathione and a stronger acid environment, and cell apoptosis is triggered; and under the dual influence of acidity / reduction in tumor cells, the medicine is quickly released, so that the treatment effect of the medicine is enhanced.
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Description

technical field

[0001] The invention relates to the technical field of controllable cross-linked polymer prodrugs, in particular to a reducing and pH ultra-sensitive cross-linked polymer prodrug and its preparation method and application. Background technique

[0002] So far, chemotherapy is still the main method of clinical treatment of cancer. However, traditional chemotherapy has disadvantages such as poor therapeutic effect and strong side effects. In order to solve these problems, nano-drug carriers have been developed to improve tumor targeting, maintain blood circulation stability, and achieve controllable drug release. At present, most mainstream nano-drug carriers are loaded with anti-tumor drugs by physically embedding them, such as doxorubicin, paclitaxel, and methotrexate.

[0003] As a broad-spectrum anticancer drug, cisplatin has a unique curative effect on reproductive system tumors (such as ovarian cancer and testicular cancer), and can work synergistically...

Claims

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