Novel compound anticoccidial soluble powder and preparation method thereof

Abstract

The invention discloses novel compound anticoccidial soluble powder and a preparation method thereof. According to the compound preparation disclosed by the invention, the problem of water solubility of trimethoprim medicine is changed by adopting a special process, the soluble powder is prepared, and the bioavailability is improved through drinking water administration; based on the cooperation of the trimethoprim and sulfachloropyrazine sodium, folic acid metabolism of coccidiosis can be blocked at the same time from two different links to achieve a synergistic effect. The TMP belongs to a sulfonamide synergistic drug, wherein the mechanism research shows that the TMP can obviously improve the anticoccidial index by being combined with sulfachloropyrazine sodium, the sulfachloropyrazine sodium and trimethoprim soluble powder is stable in drug property and exact in clinical test curative effect, the anticoccidial index of a single drug is obviously improved through combined drug use, and the drug use period is shortened, Therefore, revolutionary significance is realized on the treatment of coccidiosis diseases.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, in particular to a novel compound anticoccidial soluble powder and a preparation method thereof. Background technique [0002] Coccidiosis is a relatively common disease in the breeding process, which has a great impact on the breeding efficiency. Every year, the loss of my country's chicken industry due to coccidiosis infectious diseases exceeds 2 billion yuan. Coccidia not only have great harm to the chicken industry, but also have great harm to rabbits; in addition, they also have certain harm to pigs, cattle, sheep, ducks, geese, etc.; because of their unique physiological structure and escape mechanism, coccidia are relatively It is easy to produce drug resistance, especially unilateral preparations. At present, the most commonly used diclazuril, toltrazuril, sulfaquinoxaline, sulfachlorpyrazine, and prohexidine have drug resistance to varying degrees. Greatly affected the effec...

AI Technical Summary

Problems solved by technology

In recent years, due to the serious problem of drug-resistant bacteria, the therapeutic effect of this type of drug in China has declined significantly. However, most other compound preparations are mainly premixed preparations, and premixed preparations are mixed with feeding, which is prone to poor mixing. The phenomenon of homogeneity, and the poor appetite of livestock and poultry with coccidiosis lead to poor market feedback, which restricts the use of premixes to a certain extent. In the current situation of increasing concentration and scale of breeding industry, it is no longer widely used.

[0003] Through the special solid dispersion (SD) process, the solubility problem of trimethoprim was solved, combined with sulfachlorpyrazine sodium to form a compound preparation, and the traditional compound preparation was mostly a premix and the problem of poor anticoccidial index of the single preparation was compared. Advantages and disadvantages of premix, solution, and soluble powder formulations. Mixed feed administration of premix is ​​prone to uneven mixing, and the appetite of livestock and poultry with coccidiosis is poor, resulting in poor market feedback. To a certain extent The use of premixes is restricted on the ground, and it is no longer widely used under the circumstances that the aquaculture industry is becoming more and more centralized and large-scale.

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