Application of combined metabolic marker for screening diabetes mellitus and kit of combined metabolic marker

A technology of markers and diabetes, which is applied in the field of kits for detecting and screening diabetic patients in the test population, and can solve the problems of rapid screening of diabetic populations and other problems
CN112903885AActive Publication Date: 2021-06-04DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Publication Date
2021-06-04

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Abstract

The invention relates to a novel application of metabolites, namely galactose, 1, 5-sorbitan, N-acetyl glucosamine and 2-hydroxybutyric acid, in fasting serum as combined markers in preparation of a kit for rapidly diagnosing diabetic patients in subjects. Whether a subject suffers from diabetes mellitus or not is judged by detecting the concentrations of the four metabolites in an empty serum sample of the subject, the combined marker variable P is calculated based on a binary logistic regression equation and an intercept point value is judged, and whether the subject suffers from diabetes or not is judged. The kit can realize high-sensitivity and high-efficiency detection, and the small molecule metabolites involved in the invention have the characteristics of low detection cost and good repeatability. The kit can be applied to auxiliary rapid screening of diabetes people, has the characteristic of mutual complementation with the traditional clinical index fasting blood glucose, and has a relatively good application prospect.
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Description

technical field

[0001] The present invention relates to novel uses of known metabolites. The present invention relates to the combination of galactose, 1,5-sorbitol, N-acetylglucosamine and 2-hydroxybutyric acid in serum as a combined marker for diagnosing diabetes, and relates to the detection and screening of diabetes in the test population Patient kit. Background technique

[0002] Diabetes is a global health problem, and its incidence is increasing year by year, but the diagnosis rate is less than 50%. Diabetic patients have various complications due to abnormal insulin function or secretion. China is the country with the largest number of diabetic patients in the world. If it cannot be intervened and treated in time, it will increase the burden on the national public health system. Currently, fasting blood glucose and the oral 75g glucose tolerance (OGTT) test are the gold standard for diagnosing diabetes. However, since the OGTT test needs to collect and test blood...

Claims

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