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Additive-manufactured porous polyetheretherketone scaffold and biological activity improvement method and application thereof

A technology of polyether ether ketone and additive manufacturing, which is applied in tissue regeneration, prosthesis, medical science, etc., and can solve problems such as inability to integrate osseointegration, hinder clinical application of PEEK composite materials, and high brittleness

Active Publication Date: 2021-06-08
JILIN UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, although these materials have attracted attention since the 1980s, the bioinert surface of PEEK composites is not conducive to cell growth and adhesion, and its inferior osseointegration ability prevents it from being compatible with human body after implantation. Human bone tissue forms strong bonds that affect the long-term stability of implant materials in the body
These shortcomings seriously hinder the clinical application of PEEK composites
In order to improve the biological activity of PEEK and its composites, many researchers have modified the surface of PEEK and its composites by physical or chemical methods, including PEEK-hydroxyapatite composites, PEEK-nanofluoroapatite composites etc., but its high brittleness, low strength and poor fatigue resistance limit its clinical application

Method used

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  • Additive-manufactured porous polyetheretherketone scaffold and biological activity improvement method and application thereof
  • Additive-manufactured porous polyetheretherketone scaffold and biological activity improvement method and application thereof
  • Additive-manufactured porous polyetheretherketone scaffold and biological activity improvement method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0049] This embodiment provides a method for improving the bioactivity of a porous polyether ether ketone scaffold manufactured by additive manufacturing, which includes the following steps:

[0050] S1. Design and use CATIA software to model, use FFF system to print a porous polyether ether ketone scaffold with a size of Φ14X3, and perform ultrasonic cleaning for 3 times (each time 30min) with acetone, ethanol, and distilled water, and then place Dry it in a vacuum oven at 60°C and store it for later use to obtain a pretreated additively manufactured porous polyetheretherketone scaffold (named PEEK).

[0051] The specific printing parameters are: the diameter of the print head is 0.4mm, the temperature of the print head is 420°C, the temperature of the bottom plate is room temperature, the temperature of the material box is 65°C, the printing speed is 30mm / min, and the thickness of the printing layer is 0.2mm.

[0052] S2. Submerge the additively manufactured porous polyether...

Embodiment 2

[0066] This embodiment provides a method for improving the bioactivity of a porous polyether ether ketone scaffold manufactured by additive manufacturing, which includes the following steps:

[0067] S1. Design and use CATIA software to model, use FFF system to print a porous polyether ether ketone scaffold with a size of Φ14X3, and perform ultrasonic cleaning for 3 times (each time 30min) with acetone, ethanol, and distilled water, and then place Dry it in a vacuum oven at 50°C and store it for later use to obtain a pretreated additively manufactured porous polyetheretherketone scaffold (named PEEK).

[0068] The specific printing parameters are: the diameter of the print head is 0.4mm, the temperature of the print head is 420°C, the temperature of the bottom plate is room temperature, the temperature of the material box is 65°C, the printing speed is 30mm / min, and the thickness of the printing layer is 0.2mm.

[0069] S2. Submerge the pretreated porous polyether ether ketone...

Embodiment 3

[0076] This embodiment provides a method for improving the bioactivity of a porous polyether ether ketone scaffold manufactured by additive manufacturing, which includes the following steps:

[0077] S1. Design and use CATIA software to model, use FFF system to print a porous polyether ether ketone scaffold with a size of Φ14X3, and perform ultrasonic cleaning for 3 times (each time 30min) with acetone, ethanol, and distilled water, and then place Dry it in a vacuum oven at 70°C and store it for later use to obtain a pretreated additively manufactured porous polyetheretherketone scaffold (named PEEK).

[0078] The specific printing parameters are: the diameter of the print head is 0.4mm, the temperature of the print head is 420°C, the temperature of the bottom plate is room temperature, the temperature of the material box is 65°C, the printing speed is 30mm / min, and the thickness of the printing layer is 0.2mm.

[0079] S2. Submerge the additively manufactured porous polyether...

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Abstract

The invention is applicable to the field of biomedical materials, and provides an additive-manufactured porous polyetheretherketone scaffold and a biological activity improvement method and application thereof. The biological activity improvement method of the additive-manufactured porous polyetheretherketone scaffold comprises the following steps: taking an additive-manufactured porous polyetheretherketone scaffold, and carrying out surface sulfonation treatment on the porous polyetheretherketone scaffold to obtain a sulfonation-treated porous polyetheretherketone scaffold; and through ultraviolet grafting, loading a composite material blending methacrylic acid esterified chitosan and cage-type polysilsesquioxane nanoparticles onto the surface of the sulfonation-treated porous polyetheretherketone scaffold so as to obtain an improved porous polyetheretherketone scaffold. Through additive manufacturing and ultraviolet grafting, the composite material blending the methacrylic acid esterified chitosan and the POSS nanoparticles is loaded on the surface of the sulfonation-treated porous polyetheretherketone scaffold, so that the biological activity and the osteogenesis integration capability of the scaffold can be enhanced.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a porous polyether ether ketone scaffold manufactured by additive manufacturing, a method for improving biological activity, and an application thereof. Background technique [0002] Polyetheretherketone (PEEK) has been introduced into orthopedic implants as a candidate material to replace metal implants. Unlike typical metal materials with high elastic modulus over 100 GPa, polyetheretherketone (PEEK) has an elastic modulus close to that of cortical bone (~20 GPa), which can alleviate the elastic loss between the implant and human bone. Risk of osteoporosis and bone resorption due to stress shielding resulting from compounding. PEEK is also non-toxic, has good chemical resistance, good biocompatibility, natural radiolucency, and even MRI (magnetic resonance imaging) compatibility. [0003] However, although these materials have attracted attention since the 1980...

Claims

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Application Information

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IPC IPC(8): C08J9/36C08L61/16C08L5/08A61L27/56A61L27/18A61L27/20
CPCC08J9/36A61L27/56A61L27/18A61L27/20A61L2430/02C08J2361/16C08J2405/08C08L61/16C08L5/08
Inventor 孙大辉刘哲闻张梅董文英赵姗姗王子航周星宇
Owner JILIN UNIV FIRST HOSPITAL
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