PHEAA-based high-toughness hydrogel as well as preparation method and application thereof

A hydrogel, high toughness technology, applied in prosthesis, tissue regeneration, medical science and other directions, to achieve the effect of good biocompatibility, good biocompatibility and good application prospects
CN112940180AActive Publication Date: 2021-06-11SICHUAN NORMAL UNIVERSITY +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN NORMAL UNIVERSITY
Publication Date
2021-06-11

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Abstract

The invention provides high-toughness hydrogel based on PHEAA as well as a preparation method and application of the high-toughness hydrogel, and belongs to the technical field of high polymer materials. The structure of the hydrogel is shown as a formula I shown in the specification, wherein x is 100-300; y is 20 to 50; and z is 50 to 300. According to the invention, N-(2-hydroxyethyl) acrylamide (HEAA) and maleic anhydride are copolymerized to obtain the hydrogel with a uniform network structure, and the hydrogel has very high fracture toughness and good biocompatibility. Because of the excellent mechanical property and biocompatibility, the hydrogel can overcome the defects of existing repair materials for tissue such as cartilage and achilles tendon, a tissue repair material with more excellent performance is prepared, and the hydrogel is expected to be widely applied to the aspects of artificial cartilage, artificial achilles tendon and the like and has a good application prospect.
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Description

technical field

[0001] The invention belongs to the technical field of polymer materials, and in particular relates to a PHEAA-based high-toughness hydrogel and its preparation method and application. Background technique

[0002] Articular cartilage defects are caused by trauma, inflammation, tumors and other diseases, and are relatively common clinical lesions. It is better than the limited blood supply in cartilage, which makes the self-repair ability of cartilage tissue poor, and large-scale cartilage damage (>4mm) cannot repair itself, because cartilage defect has become one of the problems that have attracted much attention in the medical field. For cartilage tissue repair, at present, it is mainly carried out by cartilage inhibition, chondrocyte transplantation or periosteum transplantation. not effectively. In recent years, artificial cartilage scaffold materials have been widely used in orthopedics to repair cartilage defects. Gel materials that are close to t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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