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PHEAA-based high-toughness hydrogel as well as preparation method and application thereof

A hydrogel, high toughness technology, applied in prosthesis, tissue regeneration, medical science and other directions, to achieve the effect of good biocompatibility, good biocompatibility and good application prospects

Active Publication Date: 2021-06-11
SICHUAN NORMAL UNIVERSITY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, no hydrogel with good biocompatibility and high toughness has been obtained by copolymerization of PHEAA and maleic anhydride (MA).

Method used

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  • PHEAA-based high-toughness hydrogel as well as preparation method and application thereof
  • PHEAA-based high-toughness hydrogel as well as preparation method and application thereof
  • PHEAA-based high-toughness hydrogel as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0045] Embodiment 1, the preparation of hydrogel of the present invention

[0046] Dissolve N-(2-hydroxyethyl)acrylamide (HEAA) and maleic anhydride (MA) with a molar ratio of 8:1 in water, that is, dissolve 8 mol HEAA and 1 mol MA in 50 mL of water, and pour into the solution under stirring Nitrogen gas was passed for 10 minutes to remove the oxygen therein, then 0.003mol of photoinitiator benzoin dimethyl ether (Irgacure-651) was added, and the wavelength was 365nm and the power was 330W under the ultraviolet lamp for 40 minutes to react with light to obtain P(HEAA-co-MA ) Hydrogel A.

Embodiment 2

[0047] Embodiment 2, the preparation of hydrogel of the present invention

[0048] Dissolve N-(2-hydroxyethyl)acrylamide (HEAA) and maleic anhydride (MA) with a molar ratio of 8:2 in water, that is, dissolve 8 mol HEAA and 2 mol MA in 50 mL of water, and pour into the solution under stirring Nitrogen was passed for 20 minutes to remove the oxygen therein, then 0.003mol photoinitiator benzoin dimethyl ether (Irgacure-651) was added, and the wavelength was 365nm and the power was 330W UV light reaction for 40 minutes to obtain P(HEAA-co-MA ) Hydrogel B.

Embodiment 3

[0049] Embodiment 3, the preparation of hydrogel of the present invention

[0050] N-(2-hydroxyethyl)acrylamide (HEAA) and maleic anhydride (MA) with a molar ratio of 12:5 were dissolved in water, that is, 12mol HEAA and 5mol MA were dissolved in 50mL of water, and added to the solution under stirring Nitrogen was passed for 60 min to remove the oxygen therein, then 0.003 mol of photoinitiator benzoin dimethyl ether (Irgacure-651) was added, and the wavelength was 365 nm and the power was 330 W. ) Hydrogel C.

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Abstract

The invention provides high-toughness hydrogel based on PHEAA as well as a preparation method and application of the high-toughness hydrogel, and belongs to the technical field of high polymer materials. The structure of the hydrogel is shown as a formula I shown in the specification, wherein x is 100-300; y is 20 to 50; and z is 50 to 300. According to the invention, N-(2-hydroxyethyl) acrylamide (HEAA) and maleic anhydride are copolymerized to obtain the hydrogel with a uniform network structure, and the hydrogel has very high fracture toughness and good biocompatibility. Because of the excellent mechanical property and biocompatibility, the hydrogel can overcome the defects of existing repair materials for tissue such as cartilage and achilles tendon, a tissue repair material with more excellent performance is prepared, and the hydrogel is expected to be widely applied to the aspects of artificial cartilage, artificial achilles tendon and the like and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a PHEAA-based high-toughness hydrogel and its preparation method and application. Background technique [0002] Articular cartilage defects are caused by trauma, inflammation, tumors and other diseases, and are relatively common clinical lesions. It is better than the limited blood supply in cartilage, which makes the self-repair ability of cartilage tissue poor, and large-scale cartilage damage (>4mm) cannot repair itself, because cartilage defect has become one of the problems that have attracted much attention in the medical field. For cartilage tissue repair, at present, it is mainly carried out by cartilage inhibition, chondrocyte transplantation or periosteum transplantation. not effectively. In recent years, artificial cartilage scaffold materials have been widely used in orthopedics to repair cartilage defects. Gel materials that are close to t...

Claims

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Application Information

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IPC IPC(8): C08F220/58C08F222/06C08F2/48A61L27/16A61L27/52
CPCC08F220/58C08F222/06C08F2/48A61L27/16A61L27/52A61L2430/06A61L2430/10C08L35/00
Inventor 王义赵丽娟吴锦荣宋永娇易龙飞刘勇伍俊良欧阳宏妍谢袁杰罗星琪
Owner SICHUAN NORMAL UNIVERSITY
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