Dual-targeting polymer drug nano-carrier as well as preparation method and application thereof

A nano-carrier and dual-targeting technology, applied in the field of nano-biomedical materials, can solve problems such as complex functions, weakened therapeutic effects, and side effects in the central nervous system
CN112957480AActive Publication Date: 2021-06-15INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
Publication Date
2021-06-15

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Abstract

The invention provides a dual-targeting polymer drug nano-carrier, and belongs to the field of nano biomedical materials. The nano-carrier comprises a nano-material formed by a poly (lactic-co-glycolic acid)-polyethylene glycol block copolymer, and the surface of the nano-material is modified with tumor targeting functional molecules and brain targeting peptides; the tumor targeting functional molecule is folic acid, and the brain targeting peptide is connected with the nano material through a sulfydryl-maleimide group. According to the invention, biodegradable polylactic acid-glycolic acid is used as a core, tumor targeting functional molecules and brain targeting peptides are modified on the surface to obtain an Angiopep-2 / folic acid dual-targeting polymer drug nano-carrier, the barrier of BBB can be effectively overcome, meanwhile, tumor cells are targeted, and the Angiopep-2 / folic acid dual-targeting polymer drug nano-carrier can be used as a drug-loaded nano-preparation for treating brain glioma.
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Description

technical field

[0001] The invention relates to the field of nano biomedical materials, in particular to a dual-targeting polymer drug nanocarrier and its preparation method and application. Background technique

[0002] Glioma is the tumor with the highest incidence rate in the central nervous system, accounting for about 46% of intracranial tumors. It is considered to be one of the most destructive and fatal tumors. ability to relapse. Due to the unclear boundary between brain tumor tissue and normal tissue, surgery is difficult to completely remove the tumor, and the success rate is low. The existence of blood-brain barrier (BBB), blood-cerebrospinal fluid barrier (BCB) and blood-tumor barrier (BTB) also makes large Some chemotherapeutic drugs are difficult to reach the brain tissue, and the drug enrichment concentration at the tumor site is low, which is not enough to kill tumor cells. Therefore, despite comprehensive treatment such as surgery, radiotherapy and chemoth...

Claims

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