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A preparation method of flexible brain nerve electrode coating and assembled electrode

An electrode coating, brain technology, applied in the direction of coating, application, diagnostic recording/measurement, etc., can solve the problem of increasing the impedance of the metal electrode site, the coating is fragile, and it takes hours or even days, etc. To achieve the effect of reducing chronic inflammatory response, reducing acute inflammatory response, and good structural regularity

Active Publication Date: 2022-05-20
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method still has serious flaws
First, most coating materials are polymers, which are difficult to dissolve in non-toxic and harmless solvents such as deionized water and normal saline; second, the complete evaporation of solvents takes hours or even days, which greatly reduces the production cost. Efficiency; third, because the coating material is diluted by solvent, the processed coating is extremely fragile and very inconvenient to handle; fourth, the injection molding method will make the metal sites of the flexible brain nerve electrodes adhere to the polymer, This will have an extremely adverse effect on the electrical characteristics of the electrode (such as increasing the impedance of the metal electrode site, weakening the spatial signal resolution of the metal electrode site)

Method used

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  • A preparation method of flexible brain nerve electrode coating and assembled electrode
  • A preparation method of flexible brain nerve electrode coating and assembled electrode
  • A preparation method of flexible brain nerve electrode coating and assembled electrode

Examples

Experimental program
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Effect test

Embodiment 1

[0047] Such as figure 1 As shown in the flowchart, it operates in an operating room environment. The analytically pure polyethylene glycol with a viscosity average molecular weight of 10000g / mol, pharmaceutical grade dexamethasone, and polylactic acid-glycolic acid copolymer loaded pharmaceutical grade dexamethasone nanoparticles were mixed in a mass ratio of 7:2:1 inside the beaker. Subsequently, the mixture was heated on a hot plate at a temperature of 120° C. for 5 minutes, and after the polyethylene glycol component was melted, the mixture was stirred at a constant temperature for 10 minutes to uniformly mix the components. Subsequently, the mixture was left to cool at room temperature for 3 min. Subsequently, place the cooled mixture in a mortar and grind it into fine particles, and use a microscope to observe to ensure that the particle size is controlled between 0.2mm-0.5mm (too coarse particles are difficult to embed into polydimethylsiloxane mold needle-shaped insi...

Embodiment 2

[0051] Such as figure 1 As shown in the flowchart, it operates in an operating room environment. The analytically pure polyethylene glycol with a viscosity average molecular weight of 20000g / mol, pharmaceutical grade dexamethasone, and polylactic acid-glycolic acid copolymer loaded pharmaceutical grade dexamethasone nanoparticles were mixed in a mass ratio of 8:1:1 inside the beaker. Subsequently, the mixture was heated on a hot plate at a temperature of 120° C. for 5 minutes, and after the polyethylene glycol component was melted, the mixture was stirred at a constant temperature for 10 minutes to uniformly mix the components. Subsequently, the mixture was left to cool at room temperature for 3 min. Subsequently, the cooled mixture is ground into fine particles in a mortar and observed with a microscope to ensure that the particle size is controlled between 0.2 mm and 0.5 mm. Use tweezers to embed the granular mixture as figure 2 The needle-shaped flow channel 2 of the p...

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Abstract

The invention discloses a preparation method of a flexible brain nerve electrode coating and an assembled electrode thereof, and relates to the field of implantable medical devices. Polyethylene glycol, pharmaceutical grade dexamethasone, and polylactic-co-glycolic acid copolymer are loaded Pharmaceutical-grade dexamethasone nanoparticles are mixed in a beaker to form a mixture, which is made into a composite coating in a specific mold and connected to flexible brain nerve electrodes through polyvinyl alcohol. The invention can quickly and easily produce a flexible brain nerve electrode composite coating with high mechanical hardness and strength, which can continuously release anti-inflammatory drugs, and assists the implantation of the flexible brain nerve electrode. Polyvinyl alcohol can be completely hydrolyzed within 1 minute, and the composite coating can be quickly separated from the nerve electrode after implantation, and there is no polymer adhesion on the metal electrode site of the nerve electrode, which will not affect the normal recording of bioelectrical signals by the electrode. At the same time, slow-release anti-inflammatory drugs can reduce the inflammatory response of the tissue.

Description

technical field [0001] The invention relates to the field of implantable medical devices, in particular to a preparation method of a flexible brain nerve electrode coating and assembled electrodes. Background technique [0002] Currently, implantable brain nerve electrodes have been widely used in the clinical treatment of neurological diseases. The structure of traditional silicon-based electrodes is hard, and after implantation, there will be a mechanical mismatch with the soft cerebral cortex tissue, which will cause rejection reactions such as irritating trauma, tissue wrapping, and chronic inflammation. In order to solve the above problems, flexible brain nerve electrodes based on soft materials (such as polyimide, parylene, SU8 photoresist) have emerged. Compared with silicon-based electrodes, the Young's modulus of flexible brain nerve electrodes is closer to that of cerebral cortex tissue, which greatly improves the mechanical adaptability between electrodes and tis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/16A61L31/14A61B5/293
CPCA61L31/10A61L31/16A61L31/148A61L2300/41A61L2300/222C08L29/04C08L67/04C08L71/02
Inventor 张文光周旭晖许李悦贺雨欣
Owner SHANGHAI JIAOTONG UNIV
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