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Antibacterial titanium and titanium alloy medical implant and preparation method thereof

A titanium alloy and plant technology, which is applied in the field of antibacterial titanium and titanium alloy medical implants and its preparation, can solve the problems of increased drug resistance of patients, reduced therapeutic effect of antibiotic-resistant patients, and complex biological safety assessment, etc. Effects of potential risk, excellent corrosion resistance and wear resistance, and high reliability

Active Publication Date: 2021-06-29
DABO MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the need to rely on antibiotics or the introduction of doping elements to achieve antibacterial properties in the prior art titanium and titanium alloy medical implants, which may easily cause increased drug resistance in patients and reduce the therapeutic effect of patients with antibiotic resistance and biological safety assessment. Complicated defects, but provide a new antibacterial titanium and titanium alloy medical implant and its preparation method

Method used

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  • Antibacterial titanium and titanium alloy medical implant and preparation method thereof
  • Antibacterial titanium and titanium alloy medical implant and preparation method thereof
  • Antibacterial titanium and titanium alloy medical implant and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] S1. Pretreatment: Ultrasonic cleaning the sample of the plant body in the titanium alloy medical device to be treated with mixed acid solution, acetone, ethanol, and deionized water for 20 minutes each, and then drying to obtain a clean plant body in the titanium alloy medical device. Wherein, the mixed acid solution is composed of hydrofluoric acid, nitric acid and deionized water, and in the mixed acid solution, the mass fraction of hydrofluoric acid is 5%, and the mass fraction of nitric acid is 50%.

[0044] S2. Alkali-heat soaking treatment: immerse the clean titanium alloy medical device internal plant body in 1mol / L NaOH aqueous solution, heat to 120°C for 1 hour, take out the titanium alloy medical device internal plant body after cooling, and clean it with deionized water. Dry in an oven at 40°C to obtain alkali-treated endoplants.

[0045] S3. The first roasting treatment: the alkali-treated inner plants were heated to 500° C. in a tube furnace and kept for 1 ...

Embodiment 2

[0054] S1. Pretreatment: Ultrasonic cleaning the sample of the plant body in the titanium alloy medical device to be treated with mixed acid solution, acetone, ethanol, and deionized water for 10 minutes each, and then drying to obtain a clean plant body in the titanium alloy medical device. Wherein, the mixed acid solution is composed of hydrofluoric acid, nitric acid and deionized water, and in the mixed acid solution, the mass fraction of hydrofluoric acid is 5%, and the mass fraction of nitric acid is 50%.

[0055] S2. Alkali-heat soaking treatment: immerse the clean titanium alloy medical device internal plant body in 5mol / L NaOH aqueous solution, heat to 240°C for 5 hours, take out the titanium alloy medical device internal plant body after cooling, and clean it with deionized water. Dry in an oven at 40°C to obtain alkali-treated endoplants.

[0056] S3. The first roasting treatment: the alkali-treated inner plants were heated in a tube furnace to 300° C., then kept for...

Embodiment 3

[0063] S1. Pretreatment: Ultrasonic cleaning the sample of the plant body in the titanium alloy medical device to be treated with mixed acid solution, acetone, ethanol, and deionized water for 30 minutes each, and then drying to obtain a clean plant body in the titanium alloy medical device. Wherein, the mixed acid solution is composed of hydrofluoric acid, nitric acid and deionized water, and in the mixed acid solution, the mass fraction of hydrofluoric acid is 5%, and the mass fraction of nitric acid is 50%.

[0064] S2. Alkali-heat soaking treatment: immerse the clean titanium alloy medical device internal plant body in 10mol / L NaOH aqueous solution, heat it to 100°C for 1 hour, take out the titanium alloy medical device internal plant body after cooling, and clean it with deionized water. Dry in an oven at 40°C to obtain alkali-treated endoplants.

[0065] S3. The first roasting treatment: the alkali-treated inner plants were heated to 600° C. in a tube furnace for 2 hours...

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Abstract

The invention belongs to the field of medical instruments, and particularly relates to an antibacterial titanium and titanium alloy medical implant and a preparation method thereof. The antibacterial titanium and titanium alloy medical implant comprises a titanium or titanium alloy implant body, and the surface of the antibacterial titanium or titanium alloy implant body is composed of titanium oxide nano columns or nano needles. By adopting the method provided by the invention, a firm and stable nano column or nano needle structure can be formed on the surface of the titanium and titanium alloy implant body, the structure stably exists under ultrasonic oscillation, the problems of falling off and dissolving are avoided, an antibacterial effect can be stably and continuously provided on the surface of the titanium and titanium alloy implant body without introducing antibiotics, and potential drug resistance cannot be brought to the corresponding surface.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to an antibacterial titanium and titanium alloy medical implant and a preparation method thereof. Background technique [0002] Implantable biomedical materials are implanted into the human body for a short or long period of time to provide mechanical support for patients or assist in functional recovery. Although the existing implant surgery is performed according to aseptic procedures, in open fractures, closed fractures There are still reports of infection during internal fixation and arthroplasty. With the widespread application of human implanted medical devices such as artificial heart valves, artificial joints, artificial blood vessels, and dental implants, the bacterial infectious diseases produced during the implantation of medical devices have become one of the important concerns of various clinical departments. This type of infection is called "Biomaterial-Cent...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/30A61L27/54C22C14/00C23C22/64C23C22/54C23C22/82
CPCA61L27/06A61L27/306A61L27/54C22C14/00C23C22/64C23C22/54C23C22/82A61L2300/102A61L2300/606A61L2300/624
Inventor 侯志勇陈艳文廖继章曾达林志雄
Owner DABO MEDICAL TECH CO LTD
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