Pepsinogen II monoclonal antibody and application thereof

A monoclonal antibody, antigen-antibody technology, applied in immunoglobulins, anti-enzyme immunoglobulins, instruments, etc., can solve the problems of low antibody activity, poor affinity, and susceptibility to lipoprotein interference, avoiding interference and low requirements. Effect
CN113045666AActive Publication Date: 2021-06-29重庆艾生斯生物工程有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
重庆艾生斯生物工程有限公司
Publication Date
2021-06-29

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Abstract

The invention relates to the technical field of biology, in particular relates to a pepsinogen II monoclonal antibody and application thereof, and discloses a group of pepsinogen II monoclonal antibodies which can be used in cooperation, which can be applied to different methodologies, accurate measurement of PGII is achieved, interference of other impurities can be avoided, and high-specificity binding is achieved. The monoclonal antibody provided by the invention can assist in research and development of medical diagnostic reagents, and has great significance.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to pepsinogen II monoclonal antibody and application thereof. Background technique

[0002] Pepsinogen (Pepsinogen or PG) is the precursor of pepsin, which is divided into pepsinogen I (PGI) and pepsinogen II (PGII) according to the difference in physical and chemical properties and immunogenicity, and is mainly secreted by the gastric mucosa. Pepsinogen has no digestive enzyme activity, and after being secreted into the gastric cavity, it is activated into pepsin with digestive activity under the action of gastric acid. In addition to its main function in the digestive tract, a small amount of pepsinogen will pass through the gastric mucosa and enter the blood circulation. The content of pepsinogen in serum can reflect the level of gastric juice secretion and the pathological changes of gastric mucosa. The content of PGII in normal human serum is 11.9±4.2ng / ml. Studies have pointed o...

Claims

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