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Preparation method of amoxicillin granules

A technology of amoxicillin and granules, applied in the field of pharmaceutical preparations, can solve problems such as poor dissolution rate

Pending Publication Date: 2021-07-06
CHINA MEHECO SANYANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of preparation method of amoxicillin granules in view of the deficiencies in the prior art, this preparation not only solves the problem of poor dissolution rate of the current amoxicillin granule preparations, but also reduces the side effects of the preparations and improves the safety , so that it can be better accepted by pediatric patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of amoxicillin granules, which comprises the following component content (g): amoxicillin 10, poloxamer 15, lactose 60, microcrystalline cellulose 12, polyvinylpyrrolidone 1.25, stevioside 1.5, di Silicon oxide 0.25.

[0032] Specifically include the following steps:

[0033] (1) the amoxicillin raw material is pulverized with a jet mill, and it is standby after crossing a 120 mesh sieve;

[0034] (2) Dissolve the amoxicillin raw material obtained in step (1) in an appropriate amount of water to obtain an aqueous amoxicillin solution, and then dissolve the poloxamer in the aqueous amoxicillin solution, or dissolve the poloxamer 188 at 60° Heating until completely melted into a molten liquid, then adding amoxicillin raw materials into the molten solution, stirring and mixing evenly;

[0035] (3) The solution obtained in step (2) is dried under reduced pressure and pulverized to obtain amoxicillin solid dispersion; wherein, it can also be dried by m...

Embodiment 2

[0041] A preparation method of amoxicillin granules, which comprises the following component content (g): amoxicillin 12, poloxamer 15, mannitol 70, hydroxypropyl cellulose 1.25, saccharin sodium 1.5, silicon dioxide 0.25 .

[0042] Specifically include the following steps:

[0043] (1) the amoxicillin raw material is pulverized with a jet mill, and it is standby after crossing a 120 mesh sieve;

[0044] (2) Dissolve the amoxicillin raw material obtained in step (1) in an appropriate amount of water to obtain an aqueous amoxicillin solution, and then dissolve the poloxamer in the aqueous amoxicillin solution, or dissolve the poloxamer 188 at 60° Heating until completely melted into a molten liquid, then adding amoxicillin raw materials into the molten solution, stirring and mixing evenly;

[0045] (3) The solution obtained in step (2) is dried under reduced pressure and pulverized to obtain amoxicillin solid dispersion; wherein, it can also be dried by methods such as decomp...

Embodiment 3

[0051] A method for preparing amoxicillin granules, comprising the following component content (g): 10 amoxicillin, 12 poloxamers, 75 sucrose, 1.5 hydroxypropyl cellulose, 1.25 aspartame, silicon dioxide 0.25.

[0052] Specifically include the following steps:

[0053] (1) the amoxicillin raw material is pulverized with a jet mill, and it is standby after crossing a 120 mesh sieve;

[0054](2) Dissolve the amoxicillin raw material obtained in step (1) in an appropriate amount of water to obtain an aqueous amoxicillin solution, and then dissolve the poloxamer in the aqueous amoxicillin solution, or dissolve the poloxamer 188 at 60° Heating until completely melted into a molten liquid, then adding amoxicillin raw materials into the molten solution, stirring and mixing evenly;

[0055] (3) The solution obtained in step (2) is dried under reduced pressure and pulverized to obtain amoxicillin solid dispersion; wherein, it can also be dried by methods such as decompression evapora...

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PUM

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Abstract

The invention discloses a preparation method of amoxicillin granules. The amoxicillin granules comprise the following components by weight percentage content: 20%-30% of amoxicillin solid dispersion, 70%-80% of filler, 1%-1.5% of adhesive, 0.5%-1.5% of sweetening agent and 0.05%-0.25% of flow aid. According to the invention, the problem of poor dissolution rate of an existing amoxicillin granule preparation is solved, the side effects of the preparation are reduced, and the safety is improved, such that the amoxicillin granule preparation can be better accepted by children patients.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a method for preparing amoxicillin granules. Background technique [0002] Amoxicillin is suitable for upper respiratory tract infections such as otitis media, sinusitis, pharyngitis, tonsillitis, etc. bacteria, Proteus mirabilis or Enterococcus faecalis, acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic streptococcus, Streptococcus pneumoniae, staphylococcus or Haemophilus influenzae, acute simple gonorrhea, etc. It has a good antibacterial effect on severe infections of the upper and lower respiratory tracts. Its preparations include capsules, tablets, granules, dispersible tablets and the like. [0003] Amoxicillin granules have the advantages of convenient administration and good patient compliance, and are widely used in children's respiratory system, urogenital system, and digestive system infections. [0004...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/43A61K47/26A61K47/10A61K47/38A61P1/00A61P11/00A61P11/02A61P11/04A61P13/00A61P27/16A61P31/04A61K9/14
CPCA61K31/43A61K9/1623A61K9/1652A61P31/04A61P27/16A61P11/02A61P11/04A61P11/00A61P13/00A61P1/00A61K9/1682A61K9/146
Inventor 傅超婷刘超罗秀莲陈晞张振宇姚清梅
Owner CHINA MEHECO SANYANG PHARMA CO LTD
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