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Coix seed extract and application thereof in preparation of medicament for treating septicemia

A technology of extract and sepsis, applied in the field of coix seed extract and its application in the preparation of medicines for treating sepsis, can solve rare problems, achieve the effects of reducing abuse, less additives, and easy factory production

Inactive Publication Date: 2021-07-09
贵州宏创农业产业开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research on the treatment of sepsis with barley is still relatively rare.

Method used

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  • Coix seed extract and application thereof in preparation of medicament for treating septicemia
  • Coix seed extract and application thereof in preparation of medicament for treating septicemia
  • Coix seed extract and application thereof in preparation of medicament for treating septicemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1, a preparation method of barley extract, comprising the following steps:

[0025] (1) Pretreatment: wash the barley, mix it with ethanol at a volume ratio of 1:1, grind it into a slurry, add a compound enzyme for enzymolysis treatment for 30 minutes, and heat to inactivate the enzyme;

[0026] Further, the compound enzyme is composed of amylase, cellulase and papain in a mass ratio of 1:0.7:0.4.

[0027] (2) Primary extraction: centrifuging the mixture obtained in step (1) to obtain sediment and supernatant, and the sediment for later use, taking the supernatant and vacuum-drying to obtain barley polysaccharide;

[0028] (3) Secondary extraction: Add a dilute acid with a pH of 4.5 to the precipitate obtained by centrifugation in step (2), homogenize and let it stand for 11 hours, then adjust the pH to 7.0, use water as a solvent, and use subcritical extraction Carry out extraction, obtain crude oil;

[0029] (4) Purification: choose macroporous adsorption resin AB-8...

Embodiment 2

[0037] 1, a preparation method of barley extract, comprising the following steps:

[0038] (1) Pretreatment: wash the barley, mix it with ethanol at a volume ratio of 1:1, grind it into a slurry, add a compound enzyme for enzymolysis treatment for 20 minutes, and heat to inactivate the enzyme;

[0039] Further, the compound enzyme is composed of amylase, cellulase and papain in a mass ratio of 1:0.6:0.3.

[0040] (2) Primary extraction: centrifuging the mixture obtained in step (1) to obtain sediment and supernatant, and the sediment for later use, taking the supernatant and vacuum-drying to obtain barley polysaccharide;

[0041] (3) Secondary extraction: add dilute acid with a pH of 4 to the precipitate obtained by centrifugation in step (2), leave it for 10 hours after homogenization, then adjust the pH to 6.8, use water as a solvent, and use subcritical extraction Carry out extraction, obtain crude oil;

[0042] (4) Purification: choose macroporous adsorption resin AB-8, ...

Embodiment 3

[0050] 1, a preparation method of barley extract, comprising the following steps:

[0051] (1) Pretreatment: wash the barley, mix it with ethanol at a volume ratio of 1:1, grind it into a slurry, add a compound enzyme for enzymolysis treatment for 35 minutes, and heat to inactivate the enzyme;

[0052] Further, the compound enzyme is composed of amylase, cellulase and papain in a mass ratio of 1:0.8:0.3.

[0053] (2) Primary extraction: centrifuging the mixture obtained in step (1) to obtain sediment and supernatant, and the sediment for later use, taking the supernatant and vacuum-drying to obtain barley polysaccharide;

[0054] (3) Secondary extraction: add a dilute acid with a pH of 5 to the precipitate obtained by centrifugation in step (2), homogenize and let it stand for 12 hours, then adjust the pH to 7.2, use water as a solvent, and use a subcritical extraction method Carry out extraction, obtain crude oil;

[0055] (4) Purification: choose macroporous adsorption res...

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Abstract

The invention belongs to the technical field of preparation of traditional Chinese medicine preparations, and particularly relates to a coix seed extract and application thereof in preparation of a medicament for treating septicemia. The different extraction methods are adopted for coix seeds, the extracts are prepared into preparations of two dosage forms, the preparations are used for treating different septicemia, pathogenic bacteria are effectively killed, meanwhile, drug resistance of flora is avoided, the treatment period is shortened, and the dependence of a human body on antibiotics is reduced.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicine preparations, and in particular relates to a coix seed extract and its application in the preparation of medicaments for treating sepsis. Background technique [0002] Sepsis refers to an acute systemic infection in which various pathogenic bacteria invade the blood circulation, grow and multiply in the blood, and produce toxins. If the bacteria that invade the bloodstream are cleared by the body's defense function, it is called bacteremia when there are no obvious symptoms of toxemia. Sepsis with multiple abscesses and a longer course is called sepsis. Pathogens usually refer to bacteria, but can also be fungi, mycobacteria, etc. The clinical manifestations are generally acute onset, chills, high fever, shortness of breath, tachycardia, rash, joint swelling and pain, hepatosplenomegaly, and mental and mental changes. In severe cases, acute organ dysfunction ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/08A61K9/48A61K47/44A61P31/04A61P31/10
CPCA61K36/8994A61K9/08A61K9/4875A61P31/04A61P31/10A61K2236/19A61K2236/15A61K2236/333A61K2236/53A61K2236/55A61K2236/37
Inventor 江河王建伦杨晓竹郑开松罗国兵
Owner 贵州宏创农业产业开发有限公司
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