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Surface-coated modified porous calcium phosphate ceramic microsphere as well as preparation method and application thereof

A technology of porous calcium phosphate and surface coating, applied in the field of medical materials for bone injury repair, can solve the problems of difficult control of ball diameter and distribution, low production efficiency, inconvenience, etc. Effects of osteodifferentiation and/or angiogenic capacity

Active Publication Date: 2021-07-20
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In summary, porous calcium phosphate bioceramic microspheres with high biological activity on the surface have unique advantages in bone defect repair, but the current technology for preparing porous calcium phosphate bioceramic microspheres has more or less low production efficiency, poor ball diameter and Distribution is difficult to control and many other problems. On this basis, it is even more inconvenient to prepare surface-coated modified porous calcium phosphate bioceramic microspheres by these technologies.

Method used

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  • Surface-coated modified porous calcium phosphate ceramic microsphere as well as preparation method and application thereof
  • Surface-coated modified porous calcium phosphate ceramic microsphere as well as preparation method and application thereof
  • Surface-coated modified porous calcium phosphate ceramic microsphere as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Uniformly mix β-tricalcium phosphate powder, microcrystalline cellulose and polystyrene microsphere pore-forming agent with a median diameter of about 40 μm to obtain a solid-phase mixture. The mass fraction of microcrystalline cellulose is 30%, and the volume ratio of pore-forming agent to β-tricalcium phosphate powder is 1.5:1. A 0.5% aqueous solution of methylcellulose was prepared and slowly added to the solid-phase mixture, and after uniform mixing, a plastic wet material was obtained, wherein the mass fraction of the binder was 40%.

[0028] 2) Put the plastic wet material obtained in step 1) into the extrusion device of the extrusion spheronizer, and extrude from an orifice plate with a diameter of 1.5mm to obtain a strip-shaped cylindrical material; pour the strip-shaped cylindrical material Into the spheronizer, rolling to get microspheres.

[0029] 3) adding magnesium phosphate powder to the microspheres of the spheronizing device in step 2) to obtain micr...

Embodiment 2

[0033] 1) Uniformly mix β-tricalcium phosphate powder, microcrystalline cellulose and polystyrene microsphere pore-forming agent with a median diameter of about 40 μm to obtain a solid-phase mixture. The mass fraction of microcrystalline cellulose is 30%, and the volume ratio of pore-forming agent to β-tricalcium phosphate powder is 1.5:1. A 0.5% aqueous solution of methylcellulose was prepared and slowly added to the solid-phase mixture, and after uniform mixing, a plastic wet material was obtained, wherein the mass fraction of the binder was 40%.

[0034] 2) Put the plastic wet material obtained in step 1) into the extrusion device of the extrusion spheronizer, and extrude from an orifice plate with a diameter of 1.5mm to obtain a strip-shaped cylindrical material; pour the strip-shaped cylindrical material Into the spheronizer, rolling to get microspheres.

[0035] 3) adding magnesium phosphate powder to the microspheres of the spheronizing device in step 2) to obtain micr...

Embodiment 3

[0039] 1) Uniformly mixing hydroxyapatite powder, microcrystalline cellulose and paraffin microsphere pore-forming agent with a median diameter of about 100 μm to obtain a solid-phase mixture. The mass fraction of microcrystalline cellulose is 20%, and the volume ratio of pore-forming agent to hydroxyapatite powder is 2:1. A 0.5% aqueous solution of methylcellulose was prepared and slowly added into the solid-phase mixture, and after uniform mixing, a plastic wet material was obtained, wherein the mass fraction of the binder was 30%.

[0040] 2) Put the plastic wet material obtained in step 1) into the extrusion device of the extrusion spheronizer, and extrude from an orifice plate with a diameter of 1.5mm to obtain a strip-shaped cylindrical material; pour the strip-shaped cylindrical material Into the spheronizer, rolling to get microspheres.

[0041] 3) Add strontium silicate powder to the microspheres of the spheronizing device in step 2) to obtain microspheres coated wit...

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Abstract

The invention discloses a surface-coated modified porous calcium phosphate ceramic microsphere as well as a preparation method and application thereof. The method comprises the following steps: 1) uniformly mixing calcium phosphate ceramic powder, an excipient and a pore-forming agent to obtain a solid-phase mixture, adding a binder solution into the solid-phase mixture, and uniformly mixing to obtain a plastic wet material; 2) loading the plastic wet material into an extrusion device of an extrusion spheronization machine to obtain a strip-shaped cylindrical material, pouring the material into a spheronization device, and rolling to obtain microspheres; (3) adding the bioactive powder into the microspheres of the rolling device to obtain microspheres of which the surfaces are coated with bioactive substances; and 4) drying the microspheres, and sintering at a high temperature in a sintering furnace to obtain the surface-coated modified porous calcium phosphate ceramic microspheres. The size and the porous structure of the surface-coated modified porous calcium phosphate ceramic microsphere prepared by the method can be adaptively adjusted, the surface has high biological activity, and the surface-coated modified porous calcium phosphate ceramic microsphere has a good application prospect as a bone defect filling and repairing material.

Description

technical field [0001] The invention relates to the technical field of bone damage repairing medical materials, in particular to a surface-coated modified porous calcium phosphate ceramic microsphere and a preparation method and application thereof. Background technique [0002] Bone defects caused by osteoporosis, congenital bone diseases or infections, bone tumors and accidental trauma are major problems in human life and health, and the demand for bone defect filling materials is also increasing day by day. Calcium phosphate ceramics are currently widely used bone filling materials in clinical practice, usually in the form of blocks or granules for bone defect filling. Calcium phosphate ceramic blocks have good integrity and are easy to fill, but most of them are pre-prepared and have a fixed shape, which makes it difficult to match bone defects with complex shapes. Calcium phosphate ceramic particles, on the contrary, can well adapt to irregular and complex bone defects...

Claims

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Application Information

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IPC IPC(8): C04B38/06C04B38/00C04B35/447C04B41/87A61L27/12A61L27/10A61L27/30A61L27/32A61L27/56
CPCC04B38/067C04B38/009C04B38/0645C04B38/0054C04B35/447A61L27/12A61L27/10A61L27/306A61L27/32A61L27/56C04B41/87C04B41/5048C04B41/009C04B41/5027A61L2430/02A61L2300/606A61L2300/412A61L2300/112A61L2300/102
Inventor 叶建东李泽远
Owner SOUTH CHINA UNIV OF TECH
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