Antibacterial and osseointegration coating formed on substrate surface and method for preparing antibacterial and osseointegration coating on substrate surface

A substrate surface, osseointegration technology, applied in the field of orthopaedic biomedical materials, can solve the problems of poor structural stability, unsatisfactory antibacterial performance and osseointegration performance, short aging, etc., to achieve structural stability, intelligent controllable and instant sterilization effect. strong effect

Active Publication Date: 2022-06-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the dual-photoresponsive zinc oxide coating is only simply coated on the surface of the titanium substrate, which has poor structural stability, short aging time, and unsatisfactory antibacterial and osseointegration properties.

Method used

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  • Antibacterial and osseointegration coating formed on substrate surface and method for preparing antibacterial and osseointegration coating on substrate surface
  • Antibacterial and osseointegration coating formed on substrate surface and method for preparing antibacterial and osseointegration coating on substrate surface
  • Antibacterial and osseointegration coating formed on substrate surface and method for preparing antibacterial and osseointegration coating on substrate surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The present embodiment is a method for preparing an antibacterial and osseointegrated coating on the surface of a substrate, comprising the following steps:

[0066] (1) soak the substrate in the adhesive;

[0067] In this embodiment, a square titanium sheet with a side length of 8 mm and a thickness of 0.5 mm and a titanium rod with a length of 1 cm and a diameter of 0.5 mm are respectively selected as the base materials, and are ground and polished step by step with #400, #800 and #1000 SiC sandpaper. Then use the solvent acetone, absolute ethanol and double distilled water to ultrasonically clean for 20min in turn, and dry for use;

[0068] Then, the cleaned titanium sheets (or titanium rods) and platinum foils were used as positive and negative electrodes, and immersed in a solution containing 0.27M NH 4 In the mixed electrolyte of glycerol / water (v / v=1:1) of F, the voltage was adjusted to 20V, and the titanium sheet (or titanium rod) was anodized for 60min to form...

Embodiment 2

[0092] This embodiment is a method for preparing an antibacterial and osseointegrated coating on the surface of a substrate, which is basically the same as that in Embodiment 1, except that step (5) is not included.

[0093] The structure of the antibacterial and osseointegrated coating formed on the surface of the substrate is as follows: Figure 10 In the figure, a represents the substrate, b represents the nanotubular layer of titanium dioxide, and c represents the copper sulfide nanoparticle coating.

[0094] The antibacterial and osseointegrated coatings formed on the surface of the substrate were observed by scanning electron microscope, and the surface morphology was as follows: Figure 11 As shown, the XPS analysis results are as follows Figure 12 shown.

[0095] Depend on Figure 11 and Figure 12 It can be seen that the surface of the titanium sheet (or titanium rod) has been modified with copper sulfide nanoparticles.

[0096] The titanium sheet (or titanium r...

Embodiment 3

[0101] A method for preparing an antibacterial and osseointegrated coating on the surface of a substrate in this example is basically the same as that in Example 1, except that in step (4), repeating step (2) and step (3) 5 or 8 or 12 times.

[0102] Taking the titanium sheet (or titanium rod) without any surface modification as a control, the antibacterial properties and osseointegration properties of the titanium sheet (or titanium rod) coated with copper sulfide nanoparticles with different assembly layers were tested respectively. The results are shown in Table 1.

[0103] Table 1

[0104]

[0105] It can be seen from Table 1 that with the increase of the number of copper sulfide nanoparticle layers, the antibacterial properties and osseointegration properties of the antibacterial and osseointegrated coatings are continuously improved.

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Abstract

The invention discloses an antibacterial and osseointegration coating formed on the surface of a substrate and a method for preparing the antibacterial and osseointegration coating on the surface of the substrate. The method comprises: (1) soaking the substrate in an adhesive; (2) soak the base material obtained in step (1) in the cationic material solution; (3) soak the base material obtained in step (2) in the copper sulfide nanoparticle solution; (4) repeat steps (2) and ( 3) At least twice. The coating is not only firmly combined with the base material and has a long-lasting effect, but also copper sulfide nanoparticles can be activated to kill bacteria under near-infrared light irradiation, achieving the effect of treating peri-implantitis, and the bactericidal effect is intelligent, controllable and instant Strong; copper sulfide nanoparticles can release divalent copper ions, activate vascular endothelial growth factor (VEGF), and then promote the formation of blood vessels and new bone in the tissue around the implant, and enhance the stability of internal fixation.

Description

technical field [0001] The invention belongs to the technical field of orthopedic biomedical materials, and particularly relates to an antibacterial and osseointegrated coating formed on the surface of a substrate and a method for preparing the antibacterial and osseointegrated coating on the surface of the substrate. Background technique [0002] Implant infections account for approximately 45% of total hospital-acquired infections and represent a significant clinical challenge. Infections caused by implants are mainly due to bacterial adhesion and colonization on their surfaces, resulting in the formation of biofilms. Once a biofilm forms on the implant surface, it will eventually lead to implant failure due to persistent inflammation and necrosis of surrounding tissue. [0003] Biofilm clearance is particularly challenging clinically because microorganisms within biofilms are resistant to host immune attack and are less susceptible to antibiotics. Surgical removal of in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/34A61L27/50A61L27/06A61L27/54
CPCA61L27/306A61L27/54A61L27/303A61L27/34A61L27/06A61L27/50A61L2300/102A61L2400/18A61L2420/08A61L2300/404C08L5/08
Inventor 叶招明章增杰俞小华滕王锶源王翊凯
Owner ZHEJIANG UNIV
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