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A kind of probiotic microcapsule and preparation method thereof

A technology of probiotics and microcapsules, applied in the direction of microcapsule preparation, microsphere preparation, bacteria, etc., can solve the problems of poor survival rate of probiotics, achieve the effect of improving efficiency, prolonging digestion time, and improving survival rate

Active Publication Date: 2021-12-31
郑州伊品医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used probiotic microencapsulation methods include spray drying, emulsification, extrusion and gel technology, etc. However, these methods still have the problem of poor survival rate of probiotics

Method used

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  • A kind of probiotic microcapsule and preparation method thereof
  • A kind of probiotic microcapsule and preparation method thereof
  • A kind of probiotic microcapsule and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0040] The present invention proposes an embodiment of a method for preparing probiotic microcapsules, comprising the steps of:

[0041] 1) was added to the porous starch phosphate buffer, allowed to stand, polyethylene imine, the reaction temperature oscillation, washed, dried, much more porous starch - carrier polyethyleneimine;

[0042] 2) The above porous starch - carrier polyethyleneimine and mixing solid fat, the emulsifier was added, 40 ℃ ~ 50 ℃ constant temperature emulsified and cooled to obtain a solid fat filled porous starch - carrier polyethyleneimine;

[0043] 3) to the filling of solid fat porous starch - carrier solution of polyethyleneimine, triethylamine, dimethyl sulfoxide, with stirring, of acetic anhydride was added, the reaction, and then dialysis, the product was freeze-dried to give acetylated porous starch - carrier polyethyleneimine;

[0044] 4) to the porous starch acetylated - polyethyleneimine carrier, adding emulsifier solution, 40 ℃ ~ 50 ℃ emulsion, ...

Embodiment 1

[0091] Example 1 Preparation method of probiotics microcapsules, including the following steps:

[0092] (1) Preparation of porous starch: 2 g of gantamic powder added to 250 mL of triangular bottle, adding 0.2 mol / L of sodium hydrogen phosphate of pH 4.6 and 0.1 mol / L citric acid buffer, 40mL, add 0.1 ml of toluene, add appropriate dilution The enzyme solution, 40 ° C, constant temperature oscillated 24 h, centrifugation, the supernatant, the precipitate was dried at 60 ° C, and the pulverized can be pulverized.

[0093] (2) Porous starch-polyethyleneimine carrier prepare: accurately weigh 2.0 g of corn porous starch, in the beaker, in order to balance the carrier, add 200 ml of phosphate buffer (pH 8.0), put 1 h, then Among them, 1.0 g of polyethylene imine was added, 40 ° C constant temperature was oscillated for 10 h, and after the reaction was completed, washed with pH 8.0 buffer until the filtrate was not trititrobenzenesulfonic acid reaction (TNBS). Wash with distilled...

Embodiment 2

[0105] Example 2 Preparation method of probiotics microcapsules, including the following steps:

[0106] In the same embodiment, the difference is that the step (12): repeats the above two steps until the four layers of layer self-assembled probiotic microcapsules are assembled.

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Abstract

The invention provides a probiotic microcapsule and a preparation method thereof, belonging to the technical field of microcapsules. The preparation method comprises the steps of: respectively preparing a porous starch-polyethyleneimine carrier, a porous starch-polyethyleneimine carrier filled with solid oil, an acetylated porous starch-polyethyleneimine carrier, and a porous starch-polyethyleneimine carrier for removing solid oil. Starch-polyethyleneimine carrier, porous starch sludge adsorbing probiotics, and bio-polyelectrolyte is used to embed the porous starch sludge adsorbing probiotics to obtain probiotic microcapsules self-assembled layer by layer. The probiotic microcapsule obtained in the invention can significantly improve the survival rate of the probiotic.

Description

Technical field [0001] The present invention belongs to the technical field of microencapsulation, particularly, to a probiotic micro-capsule preparation method thereof. Background technique [0002] Probiotics are a class of beneficial microbial activity, with the regulation of the host intestinal flora balance, promote intestinal absorption of nutrients, we have long been committed to the combination of probiotics and food preparation containing functional probiotics food, health food. For example, the probiotic is added to yogurt, milk drinks, milk, bread and biscuits and other products, the preparation of probiotic bacterial powder, capsule and the like. However, some unfavorable factors (e.g. temperature, processing conditions, gastric acid in the digestive tract, bile salts, etc.) will cause a loss of activity of probiotics, reducing its efficacy in the host's health. [0003] In order to ensure a sufficient amount of viable bacteria colonize the gut (US FDA recommended amo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/135A23L29/30A23L29/00A23L29/10A23P10/30C12N1/20
CPCA23L33/135A23L29/30A23L29/045A23L29/035A23L29/04A23L29/10A23P10/30C12N1/20A23V2002/00B01J13/02A23V2200/3204A23V2250/5118A23V2250/1618A23V2250/1614A23V2250/032A23V2250/18A23V2250/511A23V2250/5072Y02A50/30
Inventor 刘欢王倩玉姚浩东胡婕伦聂少平谢明勇
Owner 郑州伊品医药科技有限公司
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