Application of plumbagin in preparation of medicine for preventing or treating Parkinson's disease

A technology for Parkinson's disease and plumbagin, which is applied in the field of new uses of plumbagin, can solve problems such as efficacy without any research, and achieve the effects of low toxicity, great new drug development value, and good application prospects.
CN113209064APending Publication Date: 2021-08-06GUILIN MEDICAL UNIVERSITY
4 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUILIN MEDICAL UNIVERSITY
Publication Date
2021-08-06

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of new application of plumbagin, and provides application of plumbagin in preparation of a medicine for preventing or treating Parkinson's disease. The toxic effect of neurotoxin MPP + / MPTP on Parkinson's disease and the toxic effect of plumbagin on antagonism of MPP <+> / MPTP on Parkinson's disease are observed through cell and animal experiments. Researches show that plumbagin can inhibit SH-SY5Y and PC12 nerve cells and dopaminergic neuron death and dyskinesia caused by neurotoxin MPP <+> / MPTP. Therefore, the plumbagin has good application prospects and huge new medicine development value in the aspects of Parkinson's disease prevention and treatment and neuroprotection.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of new applications of plumbagin, in particular to the application of plumbagin in the preparation of drugs for preventing or treating Parkinson's disease. Background technique

[0002] Parkinson's disease (PD) is a progressive neurodegenerative disease commonly seen in the elderly. The prevalence rate of people over 65 years old in my country is about 1.7%. Its main clinical symptoms are resting tremor, muscle Rigidity, bradykinesia, and abnormal gait, non-motor symptoms manifest as sleep disturbance, constipation, depression, hyposmia, etc. The main pathological features of this disease are the loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of Lewy bodies mainly composed of α-synuclein. The pathogenesis of Parkinson's disease is complex and closely related to mitochondrial dysfunction, oxidative stress, abnormal aggregation of α-synuclein, neuroinflammation, autophagy ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More