Red light carbonized polymer dot based on citric acid and benzoylurea and preparation method and application thereof

Abstract

The invention discloses a red light carbonized polymer dot based on citric acid and benzoylurea and a preparation method and application thereof, the raw materials of the red light carbonized polymer dot based on citric acid and benzoylurea comprise citric acid and benzoylurea, and the mass ratio of citric acid to benzoylurea is (0.5-3): (1-6). The N, N-dimethylformamide is used as a solvent, ammonium fluoride is used as a fluorine source additive, the surface polymer state is enriched while the carbon nucleus crystalline state of the RCBCPDs is enhanced, and the RCBCPDs are promoted to have a larger multi-photon absorption cross section after fluorine is introduced, so that a stronger fluorescence imaging effect is displayed in vitro and in vivo. On the basis of a citric acid and benzoylurea carbon dot preparation system, the carbonized polymer dots RCBCPDs with red light are developed, and the carbonized polymer dots are simple in preparation method, excellent in fluorescent property and wide in application prospect. When the RCBCPDs obtained by the invention are applied to cell imaging and in-vivo imaging, the RCBCPDs show interference resistance in cells and mice, and have the advantages of high selectivity, high sensitivity and the like.

Description

technical field

[0001] The invention relates to the preparation of fluorescent nanomaterials, specifically a red-light carbonized polymer dot based on citric acid and benzoylurea, a preparation method and application thereof, and belongs to the technical field of application of red-light carbonized polymer dots. Background technique

[0002] During the development of more than ten years, carbon dots have attracted the attention of many scholars due to their excellent luminescent properties and superior biocompatibility. Carbon dots synthesized by "top-down" or "bottom-up" methods can usually be approximated as a "core-shell" structure, and graphene quantum dots and carbon quantum dots often have clear and clear carbon cores. structure, its "shell" is composed of many surface functional groups (such as -COOH, -SH, O=C-NH and C=O, etc.), while the carbon core of carbonized polymer dots is far less crystalline than the former two, but The structure of the "shell" is highly com...

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