A method for preparing 2-[phenyl]-1,2,4-triazine-3,5(2h,4h)-dione compounds

A technology of compounds and diketones, which is applied in the field of veterinary medicine, can solve the problems of high unit consumption of raw materials, low product purity, and low yield, and achieve the effects of shortening the reaction steps, improving economic benefits, and reducing emissions
CN113248454BActive Publication Date: 2021-09-24SHANDONG GUOBANG PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG GUOBANG PHARMA
Publication Date
2021-09-24

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Abstract

The present invention relates to the technical field of veterinary medicine, in particular to a method for preparing 2-[phenyl]-1,2,4-triazine-3,5(2H,4H)-diketone compounds, comprising the following steps: (1 ) using dichloroacetyl chloride and ethyl carbamate as reaction raw materials, adding an acid-binding agent and a reaction solvent, heating and undergoing heat preservation reaction, distillation and rectification to obtain (2,2-dichloroacetyl) ethyl carbamate; (2) adding the aniline compound shown in structural formula 2 into hydrochloric acid, after being treated with diazotization reagent, reducing reagent, and acid precipitation reagent, and then washing with neutralization water to obtain the phenylhydrazine compound shown in structural formula 3; (3) Add phenylhydrazine compounds and (2,2-dichloroacetyl) ethyl carbamate into anhydrous acetic acid, add reaction aids, heat until the reaction is complete, and then undergo distillation to obtain 2-[phenyl]-1, 2,4‑triazine‑3,5(2H,4H)‑diones. By using the method, the overall reaction steps are shortened, the economic benefit is improved, and the discharge of three wastes is reduced.
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Description

technical field

[0001] The invention relates to the technical field of veterinary medicine, in particular to a method for preparing 2-[phenyl]-1,2,4-triazine-3,5(2H,4H)-dione compounds. Background technique

[0002] The triazine ring veterinary drugs salizuril and diclazuril are broad-spectrum anticoccidiostats with high efficiency and low toxicity. It can be used clinically for the control of poultry coccidiosis. Existing anticoccidial drugs such as toltrazuril, diclazuril, and samizuril generally have good anticoccidial properties, diclazuril has a lower dosage, and samizuril has a lower The drug resistance makes it widely used in the control of poultry coccidiosis. The synthesis process of the existing diclazuril and samizuril triazine rings is to add diethoxycarbonyl malonamide to the aniline compound under acetic acid solvent, add dropwise sodium nitrite aqueous solution to carry out diazonium, and then keep warm for coupling. Cyclization under the condition of sodiu...

Claims

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