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Polyphosphazene-based hydrogel wound dressing with antibacterial and wet surface adhesion properties, and preparation method thereof

A wound dressing and hydrogel technology, applied in pharmaceutical formulations, pharmaceutical sciences, drug delivery, etc., can solve the problems of the wounded being unable to receive professional care, difficult to effectively control bleeding, unable to meet emergency hemostasis, etc. Effects of wound healing properties, excellent hemostatic properties, and good self-healing properties

Active Publication Date: 2021-08-27
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostasis method currently used is usually traditional dressing to stop bleeding. The materials used for dressing to stop bleeding mainly include first aid kits, tourniquets, four-head bands and bandages. Tissue adhesion and other problems, especially for irregularly shaped human body parts such as the chest, abdomen, neck, and deep, narrow, ruptured arteries and other wounds, it is difficult or impossible to use hemostasis
For example: 90% of war wounds are caused by penetrating shrapnel and improvised explosive devices. These large and irregular wounds cannot be effectively controlled by traditional hemostatic materials; Professional care, emergency self-rescue is required to improve survival rate
Traditional hemostatic materials can no longer meet the needs of emergency hemostasis, and there is an urgent need for fast, efficient and safe new emergency wound antibacterial and hemostatic materials

Method used

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  • Polyphosphazene-based hydrogel wound dressing with antibacterial and wet surface adhesion properties, and preparation method thereof
  • Polyphosphazene-based hydrogel wound dressing with antibacterial and wet surface adhesion properties, and preparation method thereof
  • Polyphosphazene-based hydrogel wound dressing with antibacterial and wet surface adhesion properties, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Dissolve 30.2 mg of polyphosphazene and 30.3 mg of polyvinyl alcohol in 970 μl of deionized water respectively, and wait until completely dissolved to obtain polyphosphazene solution and polyvinyl alcohol solution.

[0041] The polyphosphazene solution and the polyvinyl alcohol solution are mixed and stirred, the rotating speed is 500-1000 rpm, and the stirring time is 50-10 minutes to obtain a polyphosphazene-based hydrogel wound dressing with deionized water as a solvent.

[0042] In the logarithmic growth phase, 10 μl of Escherichia coli ATCC25922 bacterial suspension with a concentration of 106 CFU was dispersed on the surface of the hydrogel wound dressing, and cultured in a 37°C constant temperature incubator for 0.5h, 1h, 2h, 3h and 4h. After co-cultivation, 1 ml of PBS solution was added to the surface of the hydrogel wound dressing and sonicated for 30 min. Take 100 μl of the solution to coat LB solid medium, culture overnight in a constant temperature incubato...

Embodiment 2

[0047] Dissolve 30.7 mg of polyphosphazene and 30.2 mg of polyvinyl alcohol in 970 μl of deionized water respectively, and wait until completely dissolved to obtain polyphosphazene solution and polyvinyl alcohol solution.

[0048] The polyphosphazene solution and the polyvinyl alcohol solution are mixed and stirred, the rotating speed is 500-1000 rpm, and the stirring time is 50-10 minutes to obtain a hydrogel wound dressing with deionized water as a solvent.

[0049] In the logarithmic growth phase, 10 μl of Escherichia coli ATCC25922 bacterial suspension with a concentration of 106 CFU was dispersed on the surface of the hydrogel wound dressing, and cultured in a 37°C constant temperature incubator for 0.5h, 1h, 2h, 3h and 4h. After co-cultivation, 1 ml of PBS solution was added to the surface of the hydrogel wound dressing and sonicated for 30 min. Take 100 μl of the solution to coat LB solid medium, culture overnight in a constant temperature incubator at 37°C, and count t...

Embodiment 3

[0054] Dissolve 30.6 mg of polyphosphazene and 30.8 mg of polyvinyl alcohol in 970 μl of deionized water respectively, and wait for complete dissolution to obtain polyphosphazene solution and polyvinyl alcohol solution.

[0055] The polyphosphazene solution and the polyvinyl alcohol solution are mixed and stirred, the rotating speed is 500-1000 rpm, and the stirring time is 50-10 minutes to obtain a hydrogel wound dressing with deionized water as a solvent.

[0056] In the logarithmic growth phase, 10 μl of Escherichia coli ATCC25922 bacterial suspension with a concentration of 106 CFU was dispersed on the surface of the hydrogel wound dressing, and cultured in a 37°C constant temperature incubator for 0.5h, 1h, 2h, 3h and 4h. After co-cultivation, 1 ml of PBS solution was added to the surface of the hydrogel wound dressing and sonicated for 30 min. Take 100 μl of the solution to coat LB solid medium, culture overnight in a constant temperature incubator at 37°C, and count the...

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Abstract

The invention discloses a preparation method of a polyphosphazene-based hydrogel wound dressing with antibacterial and wet surface adhesion properties. The hydrogel wound dressing is prepared by forming boric acid ester bonds between hydrophilic polyphosphazene containing phenylboronic acid functional groups and polyvinyl alcohol. The hydrogel wound dressing disclosed by the invention realizes passive contact antibacterial property through rich tertiary amine and quaternary ammonium salt functional groups in a cross-linked skeleton. The polyvinyl alcohol chain segment can provide a large number of hydrogen bonds, and cooperates with a cation-pi structure in a hydrogel skeleton to provide wet surface adhesion performance. The antibacterial and wet surface adhesion purposes can be achieved, good biocompatibility and self-healing performance are achieved, and wound healing can be promoted.

Description

technical field [0001] The invention belongs to the technical field of polymer materials and relates to a hydrogel wound dressing and a preparation method thereof, in particular to a preparation method of a polyphosphazene-based hydrogel wound dressing with antibacterial and wet surface adhesion properties. Background technique [0002] Uncontrolled bleeding and infection are considered the leading causes of death in emergencies such as war, accidents and natural disasters. According to incomplete statistics, the number of deaths caused by uncontrolled pre-hospital emergency bleeding accounts for about one-third of the total number of pre-hospital deaths every year. Rapid control of bleeding in emergency situations is of great significance to saving lives. The hemostasis method currently used is usually traditional dressing to stop bleeding. The materials used for dressing to stop bleeding mainly include first aid kits, tourniquets, four-head bands and bandages. Tissue adh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0061A61L26/0052A61L2300/404A61L2400/04C08L85/02C08L29/04
Inventor 俞豪杰倪志鹏王立
Owner ZHEJIANG UNIV
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