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Gelatin-based biocompatible polymer dressing

A biocompatible, polymer technology, applied in medical science, bandages, etc., can solve the problems of low wound healing promotion effect, synthetic hydrocolloid dressings unable to provide good support for wound cell migration, limited biological inertness of materials, etc. Achieving the effect of uniform and delicate texture, promoting the healing of chronic skin wounds, and steadily healing

Pending Publication Date: 2021-09-07
블라파르바이오테크놀로지항저우리미티드
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, also limited by the biological inertness of materials, synthetic hydrocolloid dressings cannot provide good support for wound cell migration, and their promotion effect on wound healing is much lower than that of natural biomaterials with biological activity.

Method used

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  • Gelatin-based biocompatible polymer dressing
  • Gelatin-based biocompatible polymer dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1 dressing

[0039] 10 grams of hyaluronic acid (weight average molecular weight: 400 kDa) was weighed and dissolved in 500 ml of deionized water to obtain a hyaluronic acid solution with a w / v concentration of 2.0%. Weigh 5.35 g of sodium periodate, add it to the hyaluronic acid solution, stir at room temperature in the dark for 24 hours, add 5 ml of ethylene glycol and continue stirring for 1 hour to terminate the reaction. The obtained solution was dialyzed in deionized water for five days to obtain 860 ml of oxidized hyaluronic acid solution, and the concentration of oxidized hyaluronic acid in the obtained solution was determined to be 8.6 mg / mL by solid content detection.

[0040] 10 g of gelatin was weighed and dissolved in 100 ml of 0.1 M (0.1 mol / L) acetic acid solution to obtain a gelatin solution with a w / v concentration of 10%. Take 232 ml of the above-mentioned oxidized hyaluronic acid solution, add it dropwise to the gelatin ...

Embodiment 2

[0041] The preparation of embodiment 2 dressings

[0042] 4 grams of starch (weight average molecular weight: 60 kDa) was weighed and dissolved in 100 ml of deionized water to obtain a starch solution with a w / v concentration of 4.0%. Weigh 5.35 g of sodium periodate, add it into the starch solution, and stir for 12 hours at room temperature in the dark, then add 5 ml of ethylene glycol and continue stirring for 1 hour to terminate the reaction. The obtained solution was dialyzed in deionized water for five days to obtain 153 ml of oxidized starch solution, and the concentration of oxidized starch in the obtained solution was determined to be 22.9 mg / mL by solid content detection.

[0043] 10 g of gelatin was weighed and dissolved in 100 ml of 0.1 M acetic acid solution to obtain a gelatin solution with a w / v concentration of 10%. Take 87 ml of the above-mentioned oxidized starch solution, add it dropwise into the gelatin solution, and stir until a uniform solution is obtaine...

Embodiment 3

[0044] The preparation of embodiment 3 dressings

[0045] Weighed 11.9 grams of chondroitin sulfate (weight average molecular weight: 100 kDa), dissolved in 100 ml of deionized water to obtain a chondroitin sulfate solution with a w / v concentration of 11.9%. Weigh 5.35 g of sodium periodate, add it into the chondroitin sulfate solution, stir at room temperature in the dark for 10 hours, add 5 ml of ethylene glycol and continue stirring for 1 hour to terminate the reaction. The obtained solution was dialyzed in deionized water for five days to obtain 348 ml of oxidized chondroitin sulfate solution, and the concentration of oxidized chondroitin sulfate in the obtained solution was determined to be 28.7 mg / mL by solid content detection.

[0046] 10 g of gelatin was weighed and dissolved in 1000 ml of 0.1 M acetic acid solution to obtain a gelatin solution with a w / v concentration of 1.0%. Take 70 ml of the above-mentioned oxidized chondroitin sulfate solution, add it dropwise to...

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Abstract

According to the invention, aiming at the chronic and difficult-to-heal wound surface, a natural polysaccharide material is subjected to oxidized modification to obtain a polysaccharide cross-linked precursor, and a composite biological material can be obtained by subjecting the polysaccharide cross-linked precursor and collagen to Schiff base condensation of an aldehyde group and an amino group under the condition that a small molecule cross-linking agent is not added, and the dressing which can be stably stored for a long time can be obtained by subjecting the material to freeze-drying and crushing. Before use, the dressing can be redissolved by using a biocompatible sterile solution, so that the liquid dressing with uniform texture can be obtained.

Description

technical field [0001] The invention belongs to the fields of biomedicine and medical cosmetology, and in particular relates to an anti-oxidation biocompatible polymer dressing and the application of the dressing in the fields of biomedicine and medical cosmetology. Background technique [0002] In the past few decades, biocompatible polymers have become a research hotspot and made great progress in the fields of biomedicine and medical cosmetology. Several representative biocompatible polymers have played a key role in the material basis. . [0003] Gelatin is another biocompatible polymer material that has received wide attention in recent years. As a multifunctional natural degradable biopolymer, gelatin has been widely used in many fields such as industry, food, medical treatment, and cosmetics. Applications. Gelatin is a natural product obtained by partial denaturation or chemical hydrolysis of collagen. The traditional raw materials for gelatin extraction are mainly ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0095A61L26/0066A61L26/008A61L2300/412C08L89/00
Inventor 王文新阿斯根石明生徐倩杨茂伟薛秀生徐勇猛
Owner 블라파르바이오테크놀로지항저우리미티드
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