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Application of total glycosides of Cistanche deserticola and echinacoside in the preparation of drugs for preventing and treating alcoholic liver injury with intestinal injury

A technology for alcoholic liver damage and intestinal damage, which is applied in the field of medicine to achieve the effects of reducing content, reducing oxidative damage, and reducing lipid deposition

Active Publication Date: 2022-05-24
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that there is currently no research on the prevention and treatment of alcoholic liver injury with intestinal damage by total glycosides of Cistanche deserticola and echinacoside, and the present invention just fills up this technical gap

Method used

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  • Application of total glycosides of Cistanche deserticola and echinacoside in the preparation of drugs for preventing and treating alcoholic liver injury with intestinal injury
  • Application of total glycosides of Cistanche deserticola and echinacoside in the preparation of drugs for preventing and treating alcoholic liver injury with intestinal injury
  • Application of total glycosides of Cistanche deserticola and echinacoside in the preparation of drugs for preventing and treating alcoholic liver injury with intestinal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: Extraction method of total glucosides of Cistanche deserticola, total polysaccharides of Cistanche deserticola and total oligosaccharides of Cistanche deserticola

[0052] Take 5 kg of Cistanche deserticola, add 8 times the amount of water, heat under reflux, 2 hours each time, extract three times in total, and combine the filtrates. The filtrate was concentrated under reduced pressure to a certain volume, 95% ethanol was added until the alcohol content reached 60%, precipitated at low temperature for 12 hours, filtered, and the precipitate was the total polysaccharide of Cistanche; , followed by elution with water and different concentrations of ethanol. The water eluate was collected and concentrated under reduced pressure to a thick paste to obtain total oligosaccharides of Cistanche; 40% ethanol eluate was collected, concentrated under reduced pressure, and dried to obtain total glucosides of Cistanche.

[0053] The total glycosides of Cistanche deser...

Embodiment 2

[0054] Example 2: Pharmacodynamic study of total glucosides of Cistanche deserticola and echinacoside in the protection of alcoholic liver injury with intestinal injury

[0055] Thirty male healthy Kunming mice were randomly divided into normal group (NOR), model group (MOD), Cistanche deserticola total glycosides group (TGs, 400mg / kg), Cistanche deserticola polysaccharide group (PSs, 400mg / kg), and Cistanche deserticola oligosaccharide group. Group (OSs, 400mg / kg) six groups, 10 in each group. The model of alcoholic liver injury was established by gavage of Hongxing Erguotou. Seven days after the modeling, normal saline and drugs were given by gavage respectively for 14 consecutive days.

[0056] HE staining ( figure 1 ) showed that the liver tissue cells in the NOR group had normal morphology, neat arrangement and complete structure; the MOD group had disordered structure, irregular cell arrangement, loose intercellular spaces, and unclear cell boundaries; the changes in ce...

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Abstract

The invention provides the application of total glycosides of cistanche deserticola and echinacoside in the preparation of medicines for preventing and treating alcoholic liver injury accompanied by intestinal injury and regulating intestinal flora. The results of pharmacological experiments showed that in the mouse model of alcoholic liver injury, total glycosides of cistanche and echinacoside could reduce the damage of liver tissue morphology in mice, reduce the lipid deposition in the liver of mice, and reduce the alanine aminotransferase (ALT) in mouse liver. ) and aspartate aminotransferase (AST) content, reduce the oxidative damage of mouse liver, reduce the damage of harmful substances such as endotoxin to the liver, and at the same time, it can also reduce the damage of mouse small intestine tissue morphology, improve the integrity of intestinal wall villi, and regulate intestinal The flora is disturbed. It can be seen that the present invention has the prospect of being developed into a drug capable of simultaneously protecting alcoholic liver injury and alcoholic intestinal injury, and has important clinical significance and commercial value.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new use of Cistanche deserticola extract, in particular to the preparation of medicaments for preventing and treating alcohol-induced liver injury accompanied by intestinal injury and regulating intestinal flora in total glucosides of Cistanche deserticola and echinacea. Applications. Background technique [0002] Alcohol consumption is a factor in a variety of diseases and impairments, and most alcoholics experience tissue damage or organ dysfunction. 20%-30% of heavy drinkers suffer from alcoholic liver diseases such as alcoholic steatohepatitis and cirrhosis. Chronic alcohol consumption can have damaging effects on growth factors, cytokines, and immune function, damaging body organs through an inflammatory response. It has been reported that the gastrointestinal tract may be an important source of inflammation in alcohol-mediated organ damage. [0003] Alcoholic liver disease is live...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K45/06A61P1/16A61P1/00A61K36/64
CPCA61K36/64A61K31/7048A61K45/06A61K9/0053A61P1/16A61P1/00A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2236/55A61K2300/00
Inventor 姜勇屠鹏飞孙嘉旭王富江逯颖媛曾克武
Owner PEKING UNIV
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