Preparation method and application of nanoscale beta-carotene particles

A carotene and nano-scale technology, which is applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of affecting product perception, poor product stability, and can only reach the micron level. Excellent solubilization performance, improved stability, and reduced interfacial tension

Pending Publication Date: 2021-10-22
PANASIA OLAUGHLIN BIO TECH WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solve the problem that after the existing oil-soluble colorant is emulsified, its particle size can only reach the micron level. At the same time, when it is dispersed in the water environment, it can be clearly felt that the solution is in a "turbid" state, which affects the appearance of the product. In addition, the product The stability is also poor and other issues

Method used

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  • Preparation method and application of nanoscale beta-carotene particles

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method for nanoscale β-carotene particles, characterized in that it comprises the steps of:

[0032] S1. Raw material pretreatment: in parts by weight, mix 1 part of β-carotene crystals with 8 parts of soybean oil, heat to 120° C. to dissolve, and obtain β-carotene oil suspension;

[0033] S2. Mixing of raw materials: in parts by weight, add 0.2 parts of vitamin E to the β-carotene oil suspension obtained in step S1, and mix well to obtain the oil phase material; mix 1 part of palmitin P90, 0.2 parts of high Hydrolyzed sunflower lecithin, 0.5 parts of enzyme-modified isoquercetin (EMIQ), 80 parts of maltodextrin and 200 parts of water are evenly mixed to obtain the water phase material;

[0034] S3. High-shear treatment: the water-phase material obtained in step S2 is sheared by a shearing machine, the shearing speed is 15,000 rpm, and when the temperature of the water-phase material reaches 50°C, slowly add the oil-phase material , continue to shear unti...

Embodiment 2

[0038] A preparation method for nanoscale β-carotene particles, characterized in that it comprises the steps of:

[0039] S1. Raw material pretreatment: in parts by weight, 1.5 parts of β-carotene crystals are mixed with 10 parts of a mixture of rapeseed oil, coconut oil and palm oil, heated to 128° C. to dissolve, and β-carotene oil suspension is obtained;

[0040] S2. Mixing of raw materials: In parts by weight, add 0.3 parts of a mixture of tert-butylhydroquinone and dibutylhydroxytoluene to the β-carotene oil suspension obtained in step S1, and mix well to obtain an oil phase material ; After mixing 3 parts of glyceryl palmitate P90, 0.6 part of high hydrolyzed sunflower lecithin, 0.7 part of vitamin C and phytic acid mixture, 85 parts of maltodextrin and 240 parts of water, the water phase material is obtained;

[0041] S3. High-shear treatment: the water-phase material obtained in step S2 is sheared by a shearing machine, and the shearing speed is 18000 rpm. When the tem...

Embodiment 3

[0045] A preparation method for nanoscale β-carotene particles, characterized in that it comprises the steps of:

[0046] S1. Raw material pretreatment: in parts by weight, mix 2 parts of β-carotene crystals with 12 parts of a mixture of coconut oil and palm oil, heat to 135° C. to dissolve, and obtain β-carotene oil suspension;

[0047] S2. Mixing of raw materials: in parts by weight, add 0.4 parts of a mixture of butylhydroxyanisole, gallic acid and tea polyphenols to the β-carotene oil suspension obtained in step S1, and mix well to obtain an oil phase material; Mix 5 parts of glyceryl palmitate P90, 1 part of highly hydrolyzed sunflower lecithin, 1 part of a mixture of enzyme-modified isoquercetin (EMIQ) and phytic acid, 90 parts of maltodextrin and 270 parts of water to obtain water Phase material;

[0048] S3. High-shear treatment: the water-phase material obtained in step S2 is sheared by a shearing machine, the shearing speed is 20,000 rpm, and when the temperature of...

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Abstract

The invention discloses a preparation method and the application of nanoscale beta-carotene particles. The preparation method comprises the following steps: S1, raw material pretreatment, S2, raw material mixing, S3, high shear treatment, S4, high pressure homogenization, and S5, spray drying. The palmitin P90 is an emulsifier which is extremely easy to dissolve in water, has an HLB (Hydrophile-Lipophile Balance) value of 18, has excellent solubilizing performance, can obviously reduce interfacial tension between an oil phase and a water phase, can dissolve various oily substances, and particularly has an extremely good solubilizing effect on beta-carotene; the high-hydrolysis sunflower lecithin has high lipophilicity, when the palmitin P90 and the high-hydrolysis sunflower lecithin are mixed according to a certain proportion, a specific emulsification system is formed, and the palmitin P90 and the high-hydrolysis sunflower lecithin have a synergistic effect, so that the prepared nanoscale beta-carotene particles are in a clarified state instead of a turbid state when being dispersed in water; Meanwhile, the stability of the product is also greatly improved.

Description

technical field [0001] The invention belongs to the technical field of food additives, and in particular relates to a preparation method and application of nano-scale beta-carotene particles. Background technique [0002] β-carotene is an important class of carotenoids, and it is a tetraterpene compound that exists widely in nature. Its molecular formula is C 40 h 56 , with a molecular weight of 536.88 and a melting point of 183°C. It is a shiny rhombohedral or plate-shaped crystalline powder. It is a reddish-purple or dark red crystalline powder at room temperature, with a little odor or odor. The dilute solution of β-carotene is orange-yellow to orange-red, and becomes red when the concentration increases. Due to its long carbon chain structure, β-carotene cannot be dissolved in water, and its solubility in neutral aqueous solution at room temperature is 1.5 ×10 -9 g / L, β-carotene is slightly soluble in a few organic solvents, such as ethanol, chloroform, triglyceride, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/55A61K8/37A61K8/31A61K8/67A61K8/34A61K8/368A61K8/9789A61K8/49A61K8/66A61K8/60A61K8/02A61Q19/00
CPCA61K8/553A61K8/375A61K8/31A61K8/678A61K8/676A61K8/347A61K8/368A61K8/9789A61K8/498A61K8/66A61K8/602A61K8/0216A61Q19/00A61K2800/592A61K2800/49A61K2800/52A61K2800/522A61K2800/10
Inventor 刘涵涛雷国泰
Owner PANASIA OLAUGHLIN BIO TECH WUHAN CO LTD
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