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Nano-zinc oxide/collagen-based antibacterial dressing and preparation method thereof

A nano-zinc oxide and collagen technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of restricting collagen dressings, enhancing cytotoxicity, high cytotoxicity, etc., to improve the quality of healing, reduce biological toxicity, and improve mechanical strength. Effect

Active Publication Date: 2021-11-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the introduction of cross-linking agents such as glutaraldehyde will increase the cytotoxicity of product dressings, which limits the application of collagen dressings. Dialdehyde polysaccharides prepared from polysaccharides can improve collagen performance while avoiding excessive cell toxicity. toxicity

Method used

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  • Nano-zinc oxide/collagen-based antibacterial dressing and preparation method thereof
  • Nano-zinc oxide/collagen-based antibacterial dressing and preparation method thereof
  • Nano-zinc oxide/collagen-based antibacterial dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] (1) Preparation of nano zinc oxide wrapped by polydopamine:

[0032] After heating 50 parts by volume of 0.2 mol / L sodium hydroxide solution to 100°C, slowly add an equivalent amount of 0.1 mol / L zinc acetate solution under stirring conditions, and react at constant temperature for 30 minutes. The suspension was separated by filtration, and vacuum-dried at 100°C to obtain nano-zinc oxide;

[0033] 0.1 parts by mass of dopamine hydrochloride was dissolved in 0.05 mol / L Tris buffer solution of pH 8.5 to obtain a solution of dopamine hydrochloride with a mass fraction of 0.1%, and 1 part by mass of nano-zinc oxide was added, and the reaction was stirred at room temperature for 1 d. The suspension was separated by filtration, and vacuum-dried at 60°C to prepare polydopamine-coated nano-zinc oxide;

[0034] (2) Preparation of modified collagen:

[0035] 1 mass part of type I collagen was dissolved in 0.5 mol / L acetic acid solution to obtain a collagen solution with a mass ...

Embodiment 2

[0038] (1) Preparation of nano zinc oxide wrapped by polydopamine:

[0039] After heating 50 parts by volume of 0.2 mol / L sodium hydroxide solution to 100°C, slowly add an equivalent amount of 0.1 mol / L zinc acetate solution under stirring conditions, and react at constant temperature for 30 minutes. The suspension was separated by filtration, and vacuum-dried at 100°C to obtain nano-zinc oxide;

[0040]0.1 parts by mass of dopamine hydrochloride was dissolved in 0.05 mol / L Tris buffer solution of pH 8.5 to obtain a solution of dopamine hydrochloride with a mass fraction of 0.1%, and 1 part by mass of nano-zinc oxide was added, and the reaction was stirred at room temperature for 1 d. The suspension was separated by filtration, and vacuum-dried at 60°C to prepare polydopamine-coated nano-zinc oxide;

[0041] (2) Preparation of modified collagen:

[0042] 1 mass part of type I collagen was dissolved in 0.5 mol / L acetic acid solution to obtain a collagen solution with a mass c...

Embodiment 3

[0045] (1) Preparation of nano zinc oxide wrapped by polydopamine:

[0046] After heating 50 parts by volume of 0.2 mol / L sodium hydroxide solution to 100°C, slowly add an equivalent amount of 0.1 mol / L zinc acetate solution under stirring conditions, and react at constant temperature for 30 minutes. The suspension was separated by filtration, and vacuum-dried at 100°C to obtain nano-zinc oxide;

[0047] 0.1 parts by mass of dopamine hydrochloride was dissolved in 0.05 mol / L Tris buffer solution of pH 8.5 to obtain a solution of dopamine hydrochloride with a mass fraction of 0.1%, and 1 part by mass of nano-zinc oxide was added, and the reaction was stirred at room temperature for 1 d. The suspension was separated by filtration, and vacuum-dried at 60°C to prepare polydopamine-coated nano-zinc oxide;

[0048] (2) Preparation of modified collagen:

[0049] 1 mass part of type I collagen was dissolved in 0.5 mol / L acetic acid solution to obtain a collagen solution with a mass ...

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Abstract

The invention discloses a nano zinc oxide / collagen-based antibacterial dressing and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing nano-zinc oxide by adopting a hydrothermal method, forming a wrapping layer on the surface of the nano-zinc oxide through dopamine auto-polymerization, and then grafting the nano-zinc oxide to a collagen molecular chain under the catalytic action of EDC / NHS to prepare a modified collagen solution. The soaking the modified collagen sponge prepared by freeze drying in a dialdehyde polysaccharide solution, and freeze-drying to obtain the nano-zinc oxide / collagen-based antibacterial dressing. Nano-zinc oxide is uniformly introduced into a collagen matrix in a chemical grafting manner, and collagen is modified by chemical crosslinking of dialdehyde polysaccharide serving as a natural polymer aldehyde crosslinking agent, so that the collagen-based antibacterial dressing with relatively high mechanical strength, good biocompatibility and broad-spectrum antibacterial activity is prepared; The invention has a good application prospect in the field of medical wound dressings.

Description

technical field [0001] The invention discloses a nano-zinc oxide / collagen-based antibacterial dressing and a preparation method thereof, and relates to the technical field of dressings, in particular to a dressing with uniform pore size, good mechanical properties, good biocompatibility and good antibacterial activity, which can be applied to wounds Healing nano zinc oxide / collagen based antibacterial dressing and preparation method thereof. Background technique [0002] In daily life, the skin is inevitably damaged by various accidents, which leads to the limitation of various functions of the skin, affects people's normal life, and even threatens the lives of the injured. In the process of skin healing, it is easy to be polluted by the external environment, the most serious of which is microbial infection, but in the process of using traditional conventional antibiotics, drug-resistant "super bacteria" will be produced, making the infection of drug-resistant bacteria gradu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/32A61L15/28A61L15/26A61L15/46A61L15/62C08G81/00C08H1/00C08G73/06
CPCA61L15/18A61L15/325A61L15/28A61L15/26A61L15/46A61L15/62C08G81/00C08H1/00C08G73/0672A61L2300/102A61L2300/404C08L89/00C08L79/04
Inventor 葛黎明廖伟栋杨敏轩李德富穆畅道
Owner SICHUAN UNIV
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