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Metal-organic/inorganic hybrid coating for promoting bone regeneration and regulating and controlling corrosion on degradable metal surface and preparation method thereof

A metal surface, bone-promoting technology, applied in the direction of metal material coating process, coating, tissue regeneration, etc., can solve the problem of insufficient bone healing and regeneration activity of zinc metal, uneven corrosion and degradation of zinc-based metal, local and small zinc metal. Pore ​​corrosion and other problems, to achieve a good ability to promote angiogenesis, inhibit osteoclast differentiation, reduce the effect of corrosion rate

Active Publication Date: 2021-11-02
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a metal-organic / inorganic hybrid coating and a preparation method thereof for promoting bone regeneration and controlling corrosion on the surface of degradable metals. One of them can solve the problem of insufficient regeneration activity of zinc metal in promoting bone healing. Construct a metal-organic / inorganic hybrid coating on the surface of zinc metal to achieve the function of promoting osteogenesis, promoting angiogenesis and inhibiting osteoclast differentiation, thereby achieving the purpose of promoting bone healing and regeneration; The problem of uniformity can be solved by constructing a metal-organic / inorganic hybrid coating on the surface of the degradable metal to solve the existing problem of severe corrosion of zinc metal parts and small holes, which is easy to cause premature fracture and failure

Method used

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  • Metal-organic/inorganic hybrid coating for promoting bone regeneration and regulating and controlling corrosion on degradable metal surface and preparation method thereof
  • Metal-organic/inorganic hybrid coating for promoting bone regeneration and regulating and controlling corrosion on degradable metal surface and preparation method thereof
  • Metal-organic/inorganic hybrid coating for promoting bone regeneration and regulating and controlling corrosion on degradable metal surface and preparation method thereof

Examples

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Embodiment 1

[0039] This embodiment provides a method for preparing a metal-organic / inorganic hybrid coating that promotes bone regeneration and regulates corrosion on a degradable metal surface, including the following steps:

[0040] S1. Polish the zinc metal disc (10mm×1.8mm) to 2000 mesh, polish and clean it. The cleaning steps are to use distilled water, absolute ethanol and acetone to clean it under ultrasonic conditions for 3 times, each time for 5 minutes, and then dry it. spare;

[0041] S2. Place the zinc metal substrate obtained in S1 at 50° C. in a mixed solution of 0.06 mol / L zinc nitrate and 0.2 mol / L sodium dihydrogen phosphate (the pH of the mixed solution is 3.9) and react for 5 minutes to obtain a zinc phosphate layer; Then drop 100 μL of 2 mg / mL dopamine solution on the surface of the sample, let it stand at room temperature for 30 minutes, and then wash and dry; repeat the steps of dropping-washing-drying 5 times to obtain a pretreated sample;

[0042] S3. Soak the pre...

Embodiment 2

[0047] This embodiment provides a method for preparing a metal-organic / inorganic hybrid coating that promotes bone regeneration and regulates corrosion on a degradable metal surface, including the following steps:

[0048] S1. Polish the zinc metal disc (10mm×1.8mm) to 2000 mesh, polish and clean it. The cleaning steps are to use distilled water, absolute ethanol and acetone to clean it under ultrasonic conditions for 3 times, each time for 5 minutes, and then dry it. spare;

[0049]S2. Place the zinc metal substrate obtained in S1 at 55° C. in a mixed solution of 0.07 mol / L zinc nitrate and 0.3 mol / L sodium dihydrogen phosphate (the pH of the mixed solution is 4.0) and react for 5 minutes to obtain a zinc phosphate layer; Then drop 100 μL of 2 mg / mL dopamine solution on the surface of the sample, let it stand at room temperature for 30 minutes, and then wash and dry; repeat the steps of dropping-washing-drying 5 times to obtain a pretreated sample;

[0050] S3. Soak the pret...

Embodiment 3

[0055] This embodiment provides a method for preparing a metal-organic / inorganic hybrid coating that promotes bone regeneration and regulates corrosion on a degradable metal surface, including the following steps:

[0056] S1. Polish the zinc metal disc (10mm×1.8mm) to 2000 mesh, polish and clean it. The cleaning steps are to use distilled water, absolute ethanol and acetone to clean it under ultrasonic conditions for 3 times, each time for 5 minutes, and then dry it. spare;

[0057] S2. Place the zinc metal substrate obtained in S1 at 55° C. in a mixed solution of 0.08 mol / L zinc nitrate and 0.4 mol / L sodium dihydrogen phosphate (the pH of the mixed solution is 3.9) and react for 5 minutes to obtain a zinc phosphate layer; Then drop 100 μL of 4 mg / mL dopamine solution on the surface of the sample, let it stand at room temperature for 30 minutes, and then wash and dry; repeat the steps of dropping-washing-drying 5 times to obtain a pretreated sample;

[0058] S3. Soak the pre...

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Abstract

The invention discloses a metal-organic / inorganic hybrid coating capable of promoting bone regeneration and regulating and controlling corrosion on a degradable metal surface and a preparation method thereof, and the metal-organic / inorganic hybrid coating capable of promoting bone regeneration and regulating and controlling corrosion and degradation is prepared in an alternate liquid phase deposition mode in combination with a chemical coordination chelation principle. According to the coating, the problem that degradable metal, especially zinc-based metal, is insufficient in bone integration and regeneration promoting activity is solved in a targeted mode, and the purpose of promoting bone healing and regeneration is achieved from three aspects of promoting bone generation, promoting angiogenesis and inhibiting osteoclast differentiation at the same time. And the problem of non-uniform corrosion of the zinc-based metal is solved, the corrosion degradation mode of the zinc metal is changed, local corrosion and small hole corrosion are avoided, and the zinc metal can be effectively prevented from being broken and losing efficacy in advance.

Description

technical field [0001] The invention belongs to the technical field of surface modification of biomaterials, and specifically relates to a metal-organic / inorganic hybrid coating for promoting bone regeneration and controlling corrosion on a degradable metal surface and a preparation method thereof. Background technique [0002] Zinc-based degradable metals have ideal corrosion rate, good mechanical properties and potential functionality of zinc ions, showing great application prospects in the field of bone implant materials. However, the unstable corrosion behavior of zinc metal, the cytotoxicity caused by the release of excessive zinc ions, and the insufficient function of promoting bone healing and regeneration limit its clinical translation application. The above problems can be effectively solved by means of surface modification. [0003] Although there have been a lot of research on zinc surface modification, most of the current modified coatings mainly focus on improv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/28A61L27/04A61L27/50A61L27/54A61L27/58C23C22/12
CPCA61L27/32A61L27/28A61L27/047A61L27/50A61L27/54A61L27/58C23C22/12A61L2430/02A61L2300/412A61L2400/18A61L2420/02A61L2420/04A61L2300/216A61L2300/102
Inventor 万国江钱军余张文泰杨雪苏恩王佳乐黄楠
Owner SOUTHWEST JIAOTONG UNIV
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