Orange light excited iridium complex and preparation method and application thereof
An iridium complex and light-excited technology, applied in the field of medicine, can solve problems such as hair loss and vomiting, patient injury, tumor recurrence, etc., and achieve the effect of strong growth inhibition ability
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Embodiment 1
[0040] The structural formula of the iridium complex excited by orange light is as follows figure 1 shown. Its synthesis method is as follows:
[0041] (1) The synthetic method of compound L1
[0042] 2,3-Diaminonaphthalene (158.2 mg, 1 mmol) and 4,4-dimethylbenzil (238.3 mg, 1 mmol) were heated to reflux at 80°C in ethanol for 12 hours and then filtered to obtain compound L1 as a yellow solid. The yield was 21.3%. Its structure was characterized by NMR, 1 H NMR (400MHz, DMSO-d6) δ8.79(s, 1H), 8.25(dd, J=6.5, 3.3Hz, 1H), 7.65(dd, J=6.5, 3.2Hz, 1H), 7.44(d, J=8.1Hz, 2H), 7.20(d, J=7.9Hz, 2H), 2.35(s, 3H).
[0043] (2) The synthetic method of Ir-Glucose complex
[0044] At 110°C, compound L1 (720.3mg, 1mmol) and iridium trichloride (328.4mg, 1.1mmol) were reacted in ethylene glycol ether / water (2:1, 21mL), heated to reflux for 12 hours and then reacted After suction filtration, the target iridium precursor was obtained as an orange-red solid with a yield of 32.5%. The ob...
experiment example 1
[0047] Dark Stability and Photostability of Iridium Complex (Ir-Glucose)
[0048]The dark stability and photostability properties of iridium complexes were analyzed by proton nuclear magnetic spectroscopy. The iridium complex was made into a solution (control sample) with MeOD and added to a nuclear magnetic tube to record its hydrogen nuclear magnetic spectrum; after that, it was placed in the dark at room temperature for 24 hours, or it was irradiated with 465nm light (39mW / cm 2 ) After 5 minutes, record the proton nuclear magnetic spectrum of the solution and the proton spectrogram of the control sample respectively and compare it to analyze its dark and photostability properties. Such as Figure 4 As shown, the spectrum of the iridium complex does not change significantly under dark and light conditions, and the dark stability and light stability are good.
experiment example 2
[0050] Photocatalytic Oxidation Ability of Iridium Complex (Ir-Glucose) to NADPH
[0051] The iridium complex (2.5μM) and NADPH (A 339nm =1) PBS solution is placed in a quartz cuvette, placed under a 595nm light source and irradiated for 30min (the light dose is 23.35J / cm 2 ), to detect the absorbance of the solution before and after illumination. The result is as Figure 5 As shown, the iridium complex has no obvious effect on NADPH in the dark, but under 595nm light radiation, it can oxidize the reduced coenzyme II (NADPH) to its oxidation state (NADP + ), indicating that the iridium complex has the ability to photocatalytically oxidize NADPH.
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