Biological particle mechanical vibration characteristic detection method and device, and application

Abstract

The invention discloses a biological particle mechanical vibration characteristic detection method and device, and application According to the biological particle mechanical vibration characteristic detection device, the measurement of a biological particle mechanical vibration characteristic is realized by utilizing a physical mechanism of resonance coupling of a mechanical resonator. The detection method comprises the following steps of: placing biological particles on a micro-nano resonance sensor; detecting the mechanical vibration spectrum of the resonance sensor; changing the mechanical vibration mode of the resonance sensor until the mechanical vibration of the biological particles and the resonance sensor reaches a resonance coupling state; and calculating the mechanical vibration frequency and the quality factor of the biological particles according to the spectrum data of the coupling state. The biological particle mechanical characteristic detection device designed by the method has the advantages of high mechanical frequency, low detection device requirement and high sensitivity, has the potential of on-chip integration, and can be widely applied to the fields of biological particle identification, precision measurement, medicine development and the like.

Description

technical field [0001] The invention relates to technical fields such as biological particle identification, precision measurement, and medical development, and in particular to a principle and device of a method for detecting mechanical properties of biological particles. Background technique [0002] The mechanical vibration properties of biological particles carry information about the structure and physiological state of organisms, which is of great significance for disease prevention, detection and treatment. At present, the main testing technologies for biological particles, such as methods such as adding biological particle mass to cause mechanical vibration frequency shift, can only detect the quality of biological particles, and cannot identify biological particles of the same mass but different types. , such as bacteria, viruses, proteins and other biological particles with smaller size and lighter weight, the disturbance introduced by themselves is small, and the ...

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Problems solved by technology

At present, the main testing technologies for biological particles, such as methods such as adding biological particle mass to cause mechanical vibration frequency shift, can only detect the quality of biological particles, and cannot identify biological particles of the same mass but different types. , such as bacteria, viruses, proteins and other biological particles with smaller size and lighter weight, the disturbance introduced by themselves is small, and the influence on the mechanical resonance frequency of the resonant sensor is very weak. In addition, technical methods such as Raman spectroscopy and near-field terahertz microscopy cannot meet the mechanical properties of larger-sized biological particles such as bacteria and viruses in terms of resolution and frequency range. New technologies are developed for The detection of the mechanical properties of biological particles is a hot research topic at home and abroad

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