A kind of preparation method of core-shell structure alginate-magnetic chitosan microspheres

The technology of chitosan microspheres and alginate is applied in the field of pharmaceutical preparations of medical engineering, which can solve the problems of difficulty in controlling the release rate of drugs, residual toxic substances, etc., and achieve the effects of good application prospect, low production cost and simple process.

Active Publication Date: 2022-07-08
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Liu et al. (Liu J, Xiao J, Li F, et al. Chitosan-sodium alginate nanoparticles as a delivery system for ε-polylysine: Preparation, characterization and antimicrobial activity, Food Control, 2018, 91) prepared loaded ε-polylysine by in situ polymerization Chitosan-sodium alginate nanoparticles of lysine, in vitro release studies found that it is difficult to control the drug release rate, and there are problems such as toxic substance residues

Method used

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  • A kind of preparation method of core-shell structure alginate-magnetic chitosan microspheres
  • A kind of preparation method of core-shell structure alginate-magnetic chitosan microspheres
  • A kind of preparation method of core-shell structure alginate-magnetic chitosan microspheres

Examples

Experimental program
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Effect test

example 1

[0031] Weigh 1.5g of chitosan and dissolve it in 40mL of hydrochloric acid solution with a mass fraction of 3%, and magnetically stir for 30min to obtain a uniform solution of chitosan; weigh 20mL of liquid paraffin and 10mL of Span 80 in a container, mix until uniform, Then add 1 mg of magnetic Fe 3 O 4 Nanoparticle solution and 1 mg of doxorubicin, continue to stir until well mixed. Add the chitosan acid solution to the prepared oil phase, continue to stir until the droplets are dispersed evenly, then the mixed solution is heated to 60°C, 0.8 mL of glutaraldehyde is added to make the mixed solution undergo cross-linking reaction, and finally the magnetic Chitosan microspheres, the macro image of the sample is shown in figure 1 shown.

[0032] Weigh 10 g of the magnetic chitosan microspheres obtained above and place it in a beaker, add 20 mL of 3ω% alginate solution, gel at 70 ° C for 2 h, then filter, wash, and finally freeze-dry to obtain the drug-carrying product. Algi...

example 2

[0034] Weigh 1.5g of chitosan and dissolve it in 40mL of hydrochloric acid solution with a mass fraction of 3%, stir magnetically for 30min to obtain a uniform solution of chitosan; weigh 30mL of liquid paraffin and 10mL of Span 80 in a container, mix until uniform, Then add 1 mg of magnetic Fe 3 O 4 Nanoparticle solution and 2 mg of doxorubicin, continue to stir until well mixed. Add the acidic solution of chitosan to the prepared oil phase, continue to stir until the droplets are dispersed evenly, then heat the mixed solution to 80 °C, add 0.8 mL of glutaraldehyde to make the mixed solution cross-linking reaction, and finally filter to obtain magnetic Chitosan Microspheres.

[0035] Weigh 10 g of the magnetic chitosan microspheres obtained above and place it in a beaker, add 20 mL of 3ω% alginate solution, gel at 70° C. for 3 h, then filter, wash, and finally freeze-dry to obtain a drug-carrying product. Alginate / magnetic chitosan microspheres with core / shell structure. ...

example 3

[0037] Weigh 2.5g of chitosan and dissolve it in 50mL of hydrochloric acid solution with a mass fraction of 4%, stir magnetically for 30min to obtain a uniform solution of chitosan; weigh 20mL of liquid paraffin and 10mL of Span 80 in a container, mix until uniform, Then add 2mg magnetic Fe 2 O 3 Nanoparticle solution and 2 mg of doxorubicin, continue to stir until well mixed. Add the chitosan acid solution to the prepared oil phase, continue to stir until the droplets are dispersed evenly, then the mixed solution is heated to 70 ° C, 2 mL of glutaraldehyde is added to make the mixed solution cross-linking reaction, and finally the magnetic shell is obtained by filtration Glycan microspheres.

[0038] Weigh 10 g of the magnetic chitosan microspheres obtained above and place it in a beaker, add 30 mL of 3ω% alginate solution, gel at 80 ° C for 2 h, then filter, wash, and finally freeze-dry to obtain a drug-carrying product. Alginate / magnetic chitosan microspheres with core / she...

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Abstract

The invention relates to a preparation method of alginate-magnetic chitosan microspheres with a core-shell structure, belonging to the field of composite preparation of magnetic chitosan drug-carrying materials and alginate. The acid salt is used as a raw material, and the invention relates to a preparation method of alginate-magnetic chitosan microspheres with a core-shell structure. Magnetic chitosan microspheres were prepared by emulsification and cross-linking method, and then alginate / magnetic chitosan microspheres with core / shell structure were obtained by D-phase emulsification method. It has excellent application prospects and unlimited potential in drug delivery. In addition, the process is simple and easy to operate, has low cost, and is easy to realize mass production.

Description

technical field [0001] The invention belongs to pharmaceutical preparations for medical engineering, relates to a preparation method of alginate-magnetic chitosan microspheres with a core-shell structure, and particularly relates to a core-shell structure alginate-magnetic chitosan microspheres Preparation and application of encapsulating drugs such as doxorubicin. Background technique [0002] With the development of science and technology, the relationship between biology and materials science is getting closer and closer. There are many kinds of biomaterials with low prices, such as natural polysaccharides such as chitosan, cellulose, and polylactic acid, which can be modified by inorganic or organic materials for antibacterial and sterilization, wound healing, tumor treatment and other fields. [0003] As an effective transport carrier, magnetic nanoparticles have received extensive attention in the fields of drug delivery, food detection, and sewage treatment in recent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/704A61K47/36A61K41/00A61P35/00
CPCA61K31/704A61K9/5073A61K9/5036A61K9/5094A61P35/00A61K41/00A61K9/0009Y02A50/30
Inventor 崔升袁美玉赵一帆
Owner NANJING TECH UNIV
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